Highlights
- •A SNP in the gene STK11 which codes for LKB1 is a risk factor for MS in women.
- •LKB1 deficiency increases inflammatory proteins including LCN-2 and OPN.
- •LCN2 and OPN levels are higher in African American female MS patients with the SNP.
- •Higher levels were seen after short, but not long, disease duration times.
- •Elevated LCN2/OPN levels may contribute to increased MS risk due to the STK11 SNP.
Abstract
Previous studies showed that depleting Liver Kinase-B1 (LKB1) from astrocytes increased
inflammatory factors lipocalin-2 (LCN2) and osteopontin (OPN) in EAE. A single nucleotide
polymorphism (SNP) in STK11 (encoding LKB1) is a risk factor for MS, suggesting increased
LCN2 or OPN contributes to risk. Serum LCN2 and OPN levels in African American female
MS patients were higher than healthy controls, and while levels increased with disease
duration in cases without the SNP, levels decreased with duration in cases with the
SNP. Increased MS risk associated with the STK11 SNP may be due to higher LCN2 or
OPN levels at early times.
Abbreviations:
ACP (Acclerated Cure Project), CIS (Clinically isolated syndrome), EAE (experimental autoimmune encephalomyelitis), HC (healthy control), ILR (, interval since last relapse), LCN2 (lipocalin-2), LKB1 (liver kinase B1), NGAL (neutrophil gelatinase associated lipocalin), OPN (osteopontin), SC (symptomatic control), SNP (single nucleotide polymorphism), STK11 (serine threonine kinase 11), WT (wild type)Keywords
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Article info
Publication history
Published online: January 11, 2022
Accepted:
January 6,
2022
Received in revised form:
January 5,
2022
Received:
November 8,
2021
Identification
Copyright
Published by Elsevier B.V.
