The change of PD1, PDL1 in experimental autoimmune encephalomyelitis treated by 1,25(OH)2D3

  • Author Footnotes
    1 These authors made equal contributions to this study.
    Qingqing Cao
    Footnotes
    1 These authors made equal contributions to this study.
    Affiliations
    Department of Neurology, Neuroscience Center, First Hospital of Jilin University, Changchun, China
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  • Author Footnotes
    1 These authors made equal contributions to this study.
    Chao Zheng
    Footnotes
    1 These authors made equal contributions to this study.
    Affiliations
    Department of Neurology, Neuroscience Center, First Hospital of Jilin University, Changchun, China
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  • Zhongxiang Xie
    Affiliations
    Department of Neurology, Linyi People's Hospital, Linyi, Shandong, China
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  • Lingling Liu
    Affiliations
    Department of Neurology, Neuroscience Center, First Hospital of Jilin University, Changchun, China
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  • Jie Zhu
    Affiliations
    Department of Neurology, Neuroscience Center, First Hospital of Jilin University, Changchun, China

    Department of Neurobiology, Care Sciences and Society, Karolinska Institute, Stockholm, Sweden
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  • Tao Jin
    Correspondence
    Corresponding author at: Department of Neurology, The First Hospital of Jilin University, Xinmin Street 71#, 130021 Changchun, China.
    Affiliations
    Department of Neurology, Neuroscience Center, First Hospital of Jilin University, Changchun, China
    Search for articles by this author
  • Author Footnotes
    1 These authors made equal contributions to this study.

      Highlights

      • The expression of PDL1 on DCs was increased by 1,25(OH)2D3 treatment.
      • The clinical symptoms of EAE significantly alleviated after transforming VD3-DCs.
      • VD3-DCs increased the expression of PD1 on T cells.

      Abstract

      Experimental autoimmune encephalomyelitis (EAE) is a common animal model that has the same pathology and pathogenesis as multiple sclerosis (MS). Dendritic cells (DCs) exert an important role in central and peripheral tolerance. DCs not only drive T cell priming and differentiation via playing antigen presentation function but mediate the resolution of advancing immune responses with its tolerogenic effect. In this study, we employed 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) to induce tolerogenic dendritic cells (VD3-DCs) revealing their therapeutic effect through an increase in the development of the negative regulatory signaling pathway programmed death 1 (PD1)/programmed death ligand 1 (PDL1).

      Graphical abstract

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