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MYMD-1, a novel alkaloid compound, ameliorates the course of experimental autoimmune encephalomyelitis

Published:November 20, 2019DOI:https://doi.org/10.1016/j.jneuroim.2019.577115

      Highlights

      • MyMD1 (Isomyosmine) is a novel plant alkaloid with immunomodulatory properties.
      • MyMD1 inhibits activation of Th1 and Th17 cells in vitro.
      • MyMD1 ameliorates the course of EAE and decreases the effector cells in the brains of mice with EAE.

      Abstract

      Multiple sclerosis (MS) is an autoimmune disease that remains in need of effective therapies. Plant-derived medicines have appealing properties for the treatment of autoimmune diseases. MYMD-1 is a synthetic plant alkaloid that has been shown to ameliorate the course of autoimmune thyroiditis. The goal of the present study was to determine whether MYMD-1 would produce similar beneficial effects in a mouse model of MS, experimental autoimmune encephalomyelitis (EAE) induced by immunization with myelin oligodendrocyte glycoprotein. MYMD-1 improved the course of EAE and suppressed activation of effector T cells without causing global immunosuppression or toxicity. These results suggest that MYMD-1 may be of interest for evaluating for the treatment of autoimmune diseases.

      Graphical abstract

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