Highlights
- •MyMD1 (Isomyosmine) is a novel plant alkaloid with immunomodulatory properties.
- •MyMD1 inhibits activation of Th1 and Th17 cells in vitro.
- •MyMD1 ameliorates the course of EAE and decreases the effector cells in the brains of mice with EAE.
Abstract
Multiple sclerosis (MS) is an autoimmune disease that remains in need of effective
therapies. Plant-derived medicines have appealing properties for the treatment of
autoimmune diseases. MYMD-1 is a synthetic plant alkaloid that has been shown to ameliorate
the course of autoimmune thyroiditis. The goal of the present study was to determine
whether MYMD-1 would produce similar beneficial effects in a mouse model of MS, experimental
autoimmune encephalomyelitis (EAE) induced by immunization with myelin oligodendrocyte
glycoprotein. MYMD-1 improved the course of EAE and suppressed activation of effector
T cells without causing global immunosuppression or toxicity. These results suggest
that MYMD-1 may be of interest for evaluating for the treatment of autoimmune diseases.
Graphical abstract
Graphical Abstract
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Article info
Publication history
Published online: November 20, 2019
Accepted:
November 19,
2019
Received in revised form:
November 13,
2019
Received:
May 3,
2019
Identification
Copyright
© 2019 Elsevier B.V. All rights reserved.
