Highlights
- •Tuftsin-phosphorylcholine (TPC) is a novel immune-modulating helminth derived compound.
- •We examine the effects of acute treatment with TPC on experimental autoimmune encephalomyelitis, a murine model of MS.
- •We propose the TPC as a novel treatment for delaying disease progression and preventing exacerbations of MS.
Abstract
Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system
(CNS) which carries a significant burden of morbidity and mortality. Herein we examine
the effects of acute treatment with tuftsin-phosphorylcholine (TPC), a novel immune-modulating
helminth derived compound, on a murine model of MS. Experimental autoimmune encephalomyelitis
(EAE) mice received acute treatment with TPC showed an improved clinical score and
significantly less signs of inflammation and demyelination in CNS tissue compared
with vehicle treated EAE mice. Our findings suggest that TPC may provide a beneficial
clinical effect in EAE and may therefore have a potential value for ameliorating clinical
manifestations and delaying disease progression in MS.
Graphical abstract
Graphical Abstract
Keywords
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Article info
Publication history
Published online: October 24, 2019
Accepted:
September 17,
2019
Received in revised form:
September 15,
2019
Received:
April 2,
2019
Identification
Copyright
© 2019 Elsevier B.V. All rights reserved.
