Highlights
- •Natalizumab treated patients had a lower percentage of CD4+ T cells in CSF expressing VLA-4.
- •Natalizumab treated patients had a higher percentage of CD4+ T cells expressing MCAM-1 in CSF.
- •Natalizumab treated patients had a higher percentage of MOG-reactive CD4+ T cells in blood.
- •Stable natalizumab patients had a higher increase of MOG-reactive CD4+ T cells expressing MCAM-1 in blood.
- •No association between disease activity and expression of MCAM-1 or ALCAM in blood of natalizumab-treated patients
Abstract
The objectives were to study the expression of very late antigen (VLA)-4, melanoma
cell adhesion molecule-1 (MCAM-1) and activated leukocyte cell adhesion molecule (ALCAM)
on CD4+ T cells during natalizumab treatment and to investigate the association with
disease activity.
We find that subgroups of autoreactive T cells are retained in peripheral blood, in
particular MOG-reactive CD4+ T cells expressing MCAM-1. The expression of MCAM-1 or
ALCAM on CD4+ T cells was, however, not clearly associated with disease activity (clinical
or MRI) during natalizumab treatment. We confirm upregulation of MCAM-1 on CD4+ T
cells during natalizumab treatment while VLA-4 is downregulated.
Graphical abstract
Graphical Abstract
Keywords
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Article info
Publication history
Published online: October 13, 2019
Accepted:
October 7,
2019
Received in revised form:
October 6,
2019
Received:
January 15,
2019
Identification
Copyright
© 2019 Elsevier B.V. All rights reserved.
