Highlights
- •Gut Brain interactions
- •Role of gut bacteria in Alzheimer's disease and possible therapeutics
- •Role of gut bacteria in Parkinson's disease and possible therapeutics
- •Role of gut bacteria in Multiple Sclerosis and possible therapeutics
- •Role of gut bacteria in Amyloid lateral sclerosis
Abstract
Gut dysbiosis, a primary factor behind various gastrointestinal disorders may also
augment lipopolysaccharides, pro-inflammatory cytokines, T helper cells and monocytes
causing increased intestinal and BBB permeability via microbiota-gut-brain axis. Consequentially,
accumulation of misfolded proteins, axonal damage and neuronal demyelination sets
in, thus facilitating the pathogenesis of neurodegenerative disorders like Parkinson's
disease, Alzheimer's disease, multiple sclerosis and amyotrophic lateral sclerosis.
Studies revealed that intake of probiotics may help in the integrity of intestinal
and BBB thus ameliorating the above neurodegenerative disorders. This review summarizes
the current understanding of the role of gut microbiota in neurodegenerative disorders
and possible intervention strategies.
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Article info
Publication history
Published online: January 09, 2019
Accepted:
January 8,
2019
Received in revised form:
December 5,
2018
Received:
October 8,
2018
Identification
Copyright
© 2019 Elsevier B.V. All rights reserved.
