Highlights
- •Estrogen treatment induces changes in the gut microbiota composition.
- •While EAE lead to gut dysbiosis, estrogen pretreatment reduced these changes.
- •A possible crosstalk between sex hormones and microbiota affects the immune system.
Abstract
Sex hormones promote immunoregulatory effects on multiple sclerosis. In the current
study we evaluated the composition of the gut microbiota and the mucosal-associated
regulatory cells in estrogen or sham treated female mice before and after autoimmune
encephalomyelitis (EAE) induction. Treatment with pregnancy levels of estrogen induces
changes in the composition and diversity of gut microbiota. Additionally, estrogen
prevents EAE-associated changes in the gut microbiota and might promote the enrichment
of bacteria that are associated with immune regulation. Our results point to a possible
cross-talk between the sex hormones and the gut microbiota, which could promote neuroprotection.
Graphical abstract
Graphical Abstract
Keywords
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Article info
Publication history
Published online: June 20, 2017
Accepted:
June 19,
2017
Received:
June 8,
2017
Identification
Copyright
© 2017 Elsevier B.V. All rights reserved.
