Highlights
- •A key feature of post-polio syndrome (PPS) is progressive loss of muscle strength.
- •In other chronic diseases muscle wasting has been linked to systemic inflammation.
- •PPS-patients had significantly increased levels of plasma TNF-α, IL-6, IL-8, and leptin compared to healthy controls.
- •Raised systemic levels of inflammatory mediators were not associated with a faster rate of clinical decline.
Abstract
A key feature of post-polio syndrome (PPS) is progressive loss of muscle strength.
In other chronic diseases systemic inflammation has been linked to muscle wasting.
In this study plasma TNF-α, IL-6, IL-8, and leptin levels were significantly increased
in PPS-patients compared to healthy controls. There was however no association between
these raised systemic levels of inflammatory mediators and long-term decline in quadriceps
strength or other clinical parameters. In conclusion, there is evidence for systemic
inflammation in PPS, yet the relationship with clinical deterioration remains tenuous.
Abbreviations:
PPS (post-polio syndrome), MU-size (motor unit size), MUAPs (single motor unit action potentials), mRNA (messenger RNA), CNS (central nervous system)Keywords
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Article info
Publication history
Published online: October 28, 2015
Accepted:
October 27,
2015
Received in revised form:
October 24,
2015
Received:
August 13,
2015
Identification
Copyright
© 2015 Elsevier B.V. Published by Elsevier Inc. All rights reserved.
