- •A key feature of post-polio syndrome (PPS) is progressive loss of muscle strength.
- •In other chronic diseases muscle wasting has been linked to systemic inflammation.
- •PPS-patients had significantly increased levels of plasma TNF-α, IL-6, IL-8, and leptin compared to healthy controls.
- •Raised systemic levels of inflammatory mediators were not associated with a faster rate of clinical decline.
Abbreviations:PPS (post-polio syndrome), MU-size (motor unit size), MUAPs (single motor unit action potentials), mRNA (messenger RNA), CNS (central nervous system)
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- Anti-interleukin-17a monoclonal antibody secukinumab in treatment of ankylosing spondylitis: a randomised, double-blind, placebo-controlled trial.Lancet. 2013; 382: 1705-1713
- Non-traditional cytokines: how catecholamines and adipokines influence macrophages in immunity, metabolism and the central nervous system.Cytokine. 2015; 72: 210-219
- Loss of motor unit size and quadriceps strength over 10 years in post-polio syndrome.Clin. Neurophysiol. 2014; 125: 1255-1260
- Change in physical mobility over 10 years in postpoliosyndrome.Neuromuscul. Disord. 2015; 25: 225-230
- Il-17 attenuates degradation of are-mrnas by changing the cooperation between AU-binding proteins and microRNA16.PLoS Genet. 2013; 9e1003747
- New neuromuscular symptoms after old polio (“the post-polio syndrome”): clinical studies and pathogenetic mechanisms.Birth Defects Orig. Artic. Ser. 1987; 23: 241-264
- Morphologic changes in the muscles of patients with postpoliomyelitis neuromuscular symptoms.Neurology. 1988; 38: 99-104
- Pro-inflammatory cytokines and motor neuron dysfunction: is there a connection in post-polio syndrome?.J. Neurol. Sci. 2002; 205: 5-8
- A long-term follow-up study of patients with post-poliomyelitis neuromuscular symptoms.N. Engl. J. Med. 1986; 314: 959-963
- Motor unit characteristics in healthy subjects and those with postpoliomyelitis syndrome: a high-density surface EMG study.Muscle Nerve. 2004; 30: 269-276
- Post-polio syndrome patients treated with intravenous immunoglobulin: a double-blinded randomized controlled pilot study.Eur. J. Neurol. 2007; 14: 60-65
- Elevated serum inflammatory markers in post-poliomyelitis syndrome.J. Neurol. Sci. 2008; 271: 80-86
- Leptin enhances the release of cytokines by peripheral blood mononuclear cells from relapsing multiple sclerosis patients.J. Clin. Immunol. 2004; 24: 287-293
- T-cell alterations in late postpoliomyelitis.Arch. Neurol. 1989; 46: 497-501
- A new and fast approach towards semg decomposition.Med. Biol. Eng. Comput. 2013; 51: 593-605
- Prior poliomyelitis-evidence of cytokine production in the central nervous system.J. Neurol. Sci. 2002; 205: 9-13
- Prior poliomyelitis-IVIg treatment reduces proinflammatory cytokine production.J. Neuroimmunol. 2004; 150: 139-144
- Identification of novel candidate protein biomarkers for the post-polio syndrome — implications for diagnosis, neurodegeneration and neuroinflammation.J. Proteome. 2009; 71: 670-681
- Intravenous immunoglobulin treatment of the post-polio syndrome: sustained effects on quality of life variables and cytokine expression after one year follow up.J. Neuroinflammation. 2012; 9: 167
- New problems in old polio patients: results of a survey of 539 polio survivors.Orthopedics. 1985; 8: 845-850
- Pyridostigmine in postpolio syndrome: no decline in fatigue and limited functional improvement.J. Neurol. Neurosurg. Psychiatry. 2003; 74: 1655-1661
- Treatment for postpolio syndrome.Cochrane Database Syst. Rev. 2015; 5cd007818
- The regulatory effects of monocytes on human natural killer cells activated by lipopolysaccharides.J. Periodontal Res. 1991; 26: 486-490
- Post-polio syndrome: identifying best practices in diagnosis & care.in: White Plains. Identifying Best Practices in Diagnosis & Care. 2000
- Early and late losses of motor units after poliomyelitis.Brain. 1997; 120: 1415-1421
- Elevated expression of prostaglandin E2 synthetic pathway in skeletal muscle of prior polio patients.J. Rehabil. Med. 2014; 46: 67-72
- Post-polio syndrome spinal cord pathology. Case report with immunopathology.Ann. N. Y. Acad. Sci. 1995; 753: 186-193
- Disability and functional assessment in former polio patients with and without postpolio syndrome.Arch. Phys. Med. Rehabil. 1999; 80: 136-143
- Long-term changes in the spinal cords of patients with old poliomyelitis. Signs of continuous disease activity.Arch. Neurol. 1988; 45: 505-508
- Muscle fiber specific apoptosis and tnf-alpha signaling in sarcopenia are attenuated by life-long calorie restriction.Fasten. J. 2005; 19: 668-670
- Dissociation between cytokine mrna expression and protein production in shigellosis.Eur. J. Immunol. 1996; 26: 1130-1138
- Current understanding of sarcopenia: possible candidates modulating muscle mass.Pflugers Arch. 2015; 467: 213-229
- Higher inflammatory marker levels in older persons: associations with 5-year change in muscle mass and muscle strength.J. Gerontol. A Biol. Sci. Med. Sci. 2009; 64: 1183-1189
- Intrathecal immune response in patients with the post-polio syndrome.N. Engl. J. Med. 1991; 325: 749-755
- Proinflammatory cytokines and skeletal muscle.Curr. Opin. Clin. Nutr. Metab. Care. 2004; 7: 265-269
- SF36 physical functioning scale and 2-minute walk test advocated as core qualifiers to evaluate physical functioning in patients with late-onset sequelae of poliomyelitis.J. Rehabil. Med. 2008; 40: 387-394
- Effect of intravenous immunoglobulin on pain in patients with post-polio syndrome.J. Rehabil. Med. 2011; 43: 1038-1040