Abstract
Behavioral and movement disorders may have antibody responses where mimicry and signal
transduction may lead to neuropsychiatric abnormalities. In our study, antibodies
in pediatric autoimmune neuropsychiatric disorders associated with streptococci (PANDAS)
reacted with the neuronal cell surface and caudate–putamen and induced calcium–calmodulin
dependent protein (CaM) kinase II activity in neuronal cells. Depletion of serum IgG
abrogated CaM kinase II cell signaling and reactivity of CSF was blocked by streptococcal
antigen N-acetyl-beta-d-glucosamine (GlcNAc). Antibodies against GlcNAc in PANDAS sera were inhibited by
lysoganglioside GM1. Results suggest that antibodies from an infection may signal neuronal cells in some
behavioral and movement disorders.
Keywords
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Article info
Publication history
Published online: July 27, 2006
Accepted:
June 21,
2006
Received in revised form:
June 17,
2006
Received:
April 20,
2006
Identification
Copyright
© 2006 Elsevier B.V. Published by Elsevier Inc. All rights reserved.
