Abstract
Since the discovery of the cannabinoid receptors and their endogenous ligands, significant
advances have been made in studying the physiological function of the endocannabinoid
system. The presence of cannabinoid receptors on cells of the immune system and anecdotal
and historical evidence suggesting that cannabis use has potent immuno-modulatory
effects, has led to research directed at understanding the function and role of these
receptors within the context of immunological cellular function. Studies from chronic
cannabis smokers have provided much of the evidence for immunomodulatory effects of
cannabis in humans, and animal and in vitro studies of immune cells such as T cells
and macrophages have also provided important evidence. Cannabinoids can modulate both
the function and secretion of cytokines from immune cells. Therefore, cannabinoids
may be considered for treatment of inflammatory disease. This review article will
highlight recent research on cannabinoids and how they interact with the immune system
and also their potential use as therapeutic agents for a number of inflammatory disorders.
Keywords
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Article info
Publication history
Published online: July 14, 2005
Accepted:
April 6,
2005
Received in revised form:
April 4,
2005
Received:
February 9,
2005
Identification
Copyright
© 2005 Elsevier B.V. Published by Elsevier Inc. All rights reserved.
