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Research Article| Volume 41, ISSUE 1, P29-34, November 1992

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Gelatinase in the cerebrospinal fluid of patients with multiple sclerosis and other inflammatory neurological disorders

DOI:https://doi.org/10.1016/0165-5728(92)90192-N
Gelatinase in the cerebrospinal fluid of patients with multiple sclerosis and other inflammatory neurological disorders
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      Abstract

      A substrate conversion assay was used to detect gelatinase activity in the cerebrospinal fluid (CSF) of patients with various neurological disorders. Two main forms of gelatinase with an apparent molecular mass of 65 and 85 kDa, respectively, could be discerned. The high molecular mass gelatinase was detectable only in samples of patients with multiple sclerosis or other inflammatory neurological disorders. A statistically significant correlation was found between the level of the 85-kDa gelatinase and the CSF cytosis. This protease could play a role in the process of demyelination and breakdown of the blood-brain barrier in certain neurological disorders, such as multiple sclerosis.

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      Article info

      Publication history

      Accepted: April 13, 1992
      Received in revised form: April 13, 1992
      Received: January 2, 1992

      Identification

      DOI: https://doi.org/10.1016/0165-5728(92)90192-N

      Copyright

      © 1992 Published by Elsevier Inc.

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