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Article Title |
Author(s) |
Type (Status) |
Available Online |
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Exploring the role of the epigenome in multiple sclerosis: A window onto cell-specific transcriptional potential
DOI: 10.1016/j.jneuroim.2011.12.012
Abstract: The field of epigenomics involves the study of chromatin, the three dimensional complex of DNA, protein and non-coding RNAs that determines the accessibility of DNA by the transcriptional ma...
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Anna Kaliszewska,
Philip L. De Jager
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Review article
(In Press Corrected Proof)
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02 February 2012 |
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Repeated morphine treatment-mediated hyperalgesia, allodynia and spinal glial activation are blocked by co-administration of a selective cannabinoid receptor type-2 agonist
DOI: 10.1016/j.jneuroim.2011.12.021
Abstract: Spinal glial activation has been implicated in sustained morphine-mediated paradoxical pain sensitization. Since activation of glial CB2 cannabinoid receptors attenuates spinal glial activat...
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Suneeta Tumati,
Tally M. Largent-Milnes,
Attila Keresztes,
Jiyang Ren,
William R. Roeske,
Todd W. Vanderah,
Eva V. Varga
et al.
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Full-length article
(In Press Corrected Proof)
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30 January 2012 |
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Next-generation sequencing approaches for genetic mapping of complex diseases
DOI: 10.1016/j.jneuroim.2011.12.017
Abstract: The advent of next generation sequencing technologies has opened new possibilities in the analysis of human disease. In this review we present the main next-generation sequencing technologie...
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Ferran Casals,
Youssef Idaghdour,
Julie Hussin,
Philip Awadalla
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Review article
(In Press Corrected Proof)
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30 January 2012 |
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Data integration and systems biology approaches for biomarker discovery: Challenges and opportunities for multiple sclerosis
DOI: 10.1016/j.jneuroim.2012.01.001
Abstract: New “omic” technologies and their application to systems biology approaches offer new opportunities for biomarker discovery in complex disorders, including multiple sclerosis (MS). Recent st...
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Pablo Villoslada,
Sergio Baranzini
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Review article
(In Press Corrected Proof)
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27 January 2012 |
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Key role of CXCL13/CXCR5 axis for cerebrospinal fluid B cell recruitment in pediatric OMS
DOI: 10.1016/j.jneuroim.2011.12.014
Abstract: To study aberrant B cell trafficking into the CSF in opsoclonus–myoclonus syndrome (OMS), chemoattractants CXCL13 and CXCL12, and B cell frequency and CXCR5 expression, were evaluated. CSF C...
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Michael R. Pranzatelli,
Elizabeth D. Tate,
Nathan R. McGee,
Anna L. Travelstead,
Richard M. Ransohoff,
Jayne M. Ness,
Jerry A. Colliver
et al.
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Full-length article
(In Press Corrected Proof)
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24 January 2012 |
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Elevation of serum TNF-α levels in mild and moderate Alzheimer patients with daytime sleepiness
DOI: 10.1016/j.jneuroim.2011.12.015
Abstract: Objectives: Sleep disturbance has been noted to accompany Alzheimer disease and is more pronounced as dementia severity increases. The aim of this study was to examine whether sleep disturba...
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Rui Chen,
You Yin,
Zhongxin Zhao,
Liuqing Huang,
Shuqi Huang,
Jianhua Zhuang,
Huijuan Wu,
Hua Peng,
Peng Li
et al.
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Full-length article
(In Press Corrected Proof)
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24 January 2012 |
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Rapamycin reduces clinical signs and neuropathic pain in a chronic model of experimental autoimmune encephalomyelitis
DOI: 10.1016/j.jneuroim.2011.12.018
Abstract: Current treatments used in Multiple Sclerosis (MS) are partly effective in the early stages of the disease but display very limited benefits in patients affected by progressive MS. One possi...
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L. Lisi,
P. Navarra,
R. Cirocchi,
A. Sharp,
E. Stigliano,
D.L. Feinstein,
C. Dello Russo
et al.
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Full-length article
(In Press Corrected Proof)
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20 January 2012 |
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Meningothelial cells participate in immunological processes in the cerebrospinal fluid
DOI: 10.1016/j.jneuroim.2011.12.027
Abstract: Meningothelial cells (MECs) form the innermost layer of the meningeal sheath and as such are in direct contact with the cerebrospinal fluid (CSF) likely influencing CSF composition. The CSF ...
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Bin Fan,
Giovanna Bordigari,
Josef Flammer,
Hanspeter E. Killer,
Peter Meyer,
Albert Neutzner
et al.
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Full-length article
(In Press Corrected Proof)
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20 January 2012 |
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Identification of continuous epitopes of HuD antibodies related to paraneoplastic diseases/small cell lung cancer
DOI: 10.1016/j.jneuroim.2011.12.020
Abstract: HuD antibodies are associated with small cell lung cancer. To identify relevant epitopes of HuD antibodies, patient sera and a monoclonal antibody were analyzed for their reactivity to linea...
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Nicole Hartwig Trier,
Paul Robert Hansen,
Christian A. Vedeler,
Finn Engeborg Somnier,
Gunnar Houen
et al.
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Full-length article
(In Press Corrected Proof)
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20 January 2012 |
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The CD4+ T-cell subset lacking expression of the CD28 costimulatory molecule is expanded and shows a higher activation state in multiple sclerosis
DOI: 10.1016/j.jneuroim.2011.11.008
Abstract: Multiple sclerosis (MS) is a chronic debilitating disease, in which T-cells are considered to play a pivotal role. CD28 is the quintessential costimulatory molecule on T-cells and its expres...
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María Jesús Pinto-Medel,
Juan Antonio García-León,
Begoña Oliver-Martos,
Carlos López-Gómez,
Gloria Luque,
Carlos Arnáiz-Urrutia,
Teresa Órpez,
Carmen Marín-Bañasco,
Oscar Fernández,
Laura Leyva
et al.
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Full-length article
(In Press Corrected Proof)
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20 January 2012 |
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The association of V249I and T280M fractalkine receptor haplotypes with disease course of multiple sclerosis
DOI: 10.1016/j.jneuroim.2011.12.028
Abstract: We investigated the association of CX3CR1 genotypes/haplotypes with MS and performed the prediction analysis of protein sequence variants' effects on CX3CL1/CX3CR1 interaction. We found no a...
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Ljiljana Stojković,
Tamara Djurić,
Aleksandra Stanković,
Evica Dinčić,
Olja Stančić,
Nevena Veljković,
Dragan Alavantić,
Maja Živković
et al.
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Full-length article
(In Press Corrected Proof)
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19 January 2012 |
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Associations of moderate alcohol consumption with clinical and MRI measures in multiple sclerosis
DOI: 10.1016/j.jneuroim.2011.12.007
Abstract: Objective: To examine the associations of alcohol consumption patterns with disability and brain injury in multiple sclerosis (MS) patients. Design: This study included 423 subjects (272 MS ...
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Mathew Foster,
Robert Zivadinov,
Bianca Weinstock-Guttman,
Miriam Tamaño-Blanco,
Darlene Badgett,
Ellen Carl,
Murali Ramanathan
et al.
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Full-length article
(In Press Corrected Proof)
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19 January 2012 |
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Frequency and function of regulatory T cells after ischaemic stroke in humans
DOI: 10.1016/j.jneuroim.2011.12.019
Abstract: Ischaemic stroke is an important cause of disability and death. Local inflammation in the brain following stroke is thought to enhance damage. Animal studies show that regulatory T cells (Tr...
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Jun Yan,
Stephen J. Read,
Robert D. Henderson,
Renee Hull,
John D. O'Sullivan,
Pamela A. McCombe,
Judith M. Greer
et al.
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Full-length article
(In Press Corrected Proof)
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19 January 2012 |
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Aberrant expression of the apoptosis-related proteins BAK and MCL1 in T cells in multiple sclerosis
DOI: 10.1016/j.jneuroim.2011.12.026
Abstract: Pathogenic T cells of multiple sclerosis (MS) patients have been suggested to be endowed with an increased resistance to apoptosis, contributing to their increased survival. We report herein...
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Ilana Mandel,
Tamar Paperna,
Ariel Miller
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Full-length article
(In Press Corrected Proof)
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18 January 2012 |
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Mediatophore regulates acetylcholine release from T cells
DOI: 10.1016/j.jneuroim.2011.12.022
Abstract: Immunological stimulation of T cells by phytohemagglutinin (PHA) enhances the synthesis and release of acetylcholine (ACh), suggesting a role for the lymphocytic cholinergic system in the re...
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Takeshi Fujii,
Yuki Takada-Takatori,
Kazuhide Horiguchi,
Koichiro Kawashima
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Full-length article
(In Press Corrected Proof)
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16 January 2012 |
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Analysis of antibodies to surface epitopes of contactin-2 in multiple sclerosis
DOI: 10.1016/j.jneuroim.2011.12.023
Abstract: Contactin-2 was recently identified as an autoantigen targeted by T-cells and autoantibodies in multiple sclerosis (MS). Here we analyzed the frequency of antibodies to contactin-2 (contacti...
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Anna Boronat,
María Sepúlveda,
Sara Llufriu,
Lidia Sabater,
Yolanda Blanco,
Iñigo Gabilondo,
Nuria Solà,
Pablo Villoslada,
Josep Dalmau,
Francesc Graus,
Albert Saiz
et al.
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Short communication
(In Press Corrected Proof)
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16 January 2012 |
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Human T cell expansion and experimental autoimmune encephalomyelitis inhibited by Lenaldekar, a small molecule discovered in a zebrafish screen
DOI: 10.1016/j.jneuroim.2011.12.024
Abstract: Immune-mediated diseases [multiple sclerosis (MS), experimental autoimmune encephalomyelitis (EAE)] are driven by proliferating, highly activated autoreactive T-cells that are unresponsive t...
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Matthew F. Cusick,
Jane E. Libbey,
Nikolaus S. Trede,
David D. Eckels,
Robert S. Fujinami
et al.
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Full-length article
(In Press Corrected Proof)
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16 January 2012 |
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Loss of class I MHC function alters behavior and stress reactivity
DOI: 10.1016/j.jneuroim.2011.12.025
Abstract: The importance of the classical immune molecule, class I major histocompatibility complex to central nervous system function is one of the most surprising discoveries related to neuroimmunol...
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Ashwin Sankar,
Robyn N. MacKenzie,
Jane A. Foster
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Full-length article
(In Press Corrected Proof)
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16 January 2012 |
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Upregulation of IL-17, but not of IL-9, in circulating cells of CIS and relapsing MS patients. Impact of corticosteroid therapy on the cytokine network
DOI: 10.1016/j.jneuroim.2011.12.010
Abstract: The concomitant production of IL-17A and IL-9, both Th17 cytokines, has not been compared in MS patients. We show that IL-17A but not IL-9 expression by CD3+ cells was increased during a MS ...
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Nathalie Muls,
Karima Jnaoui,
Hong Anh Dang,
Antony Wauters,
Jacques Van Snick,
Christian Jean-Marie Sindic,
Vincent van Pesch
et al.
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Full-length article
(In Press Corrected Proof)
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16 January 2012 |
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Palmitoylethanolamide stimulates phagocytosis of Escherichia coli K1 and Streptococcus pneumoniae R6 by microglial cells
DOI: 10.1016/j.jneuroim.2011.12.013
Abstract: The ability of microglial cells to phagocytose bacteria after stimulation with the endocannabinoid palmitoylethanolamide (PEA) was studied in vitro. PEA increased the phagocytosis of unencap...
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Sandra Redlich,
Sandra Ribes,
Sandra Schütze,
Dirk Czesnik,
Roland Nau
et al.
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Short communication
(In Press Corrected Proof)
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13 January 2012 |
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No evidence for an anti-inflammatory effect of escitalopram intervention in healthy individuals with a family history of depression
DOI: 10.1016/j.jneuroim.2011.12.006
Abstract: Inflammation may contribute to the pathogenesis of depression and antidepressants are hypothesised to have an anti-inflammatory effect. In this randomised double-blinded trial we investigate...
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Eva Haastrup,
Ulla Knorr,
Christian Erikstrup,
Lars Vedel Kessing,
Henrik Ullum
et al.
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Full-length article
(In Press Corrected Proof)
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13 January 2012 |
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Stress and the anti-influenza immune response: Repeated social defeat augments clonal expansion of CD8+T cells during primary influenza A viral infection
DOI: 10.1016/j.jneuroim.2011.12.011
Abstract: Social disruption stress (SDR) prior to primary influenza A virus (IAV) infection augments memory to IAV re-challenge in a T cell-specific manner. However, the effect of SDR on the primary a...
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Jacqueline W. Mays,
Nicole D. Powell,
John T. Hunzeker,
Mark L. Hanke,
Michael T. Bailey,
John F. Sheridan
et al.
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Full-length article
(In Press Corrected Proof)
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13 January 2012 |
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The effect of TNF-alpha, FcγR and CD1 polymorphisms on Guillain–Barré syndrome risk: Evidences from a Meta-Analysis
DOI: 10.1016/j.jneuroim.2011.12.003
Abstract: Background and objectives The findings on the associations between potential genetic variants and risk of Guillain–Barré syndrome (GBS) are controversial. We conducted a meta-analysis for ca...
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Li-ya Wu,
You Zhou,
Chao Qin,
Bang-li Hu
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Full-length article
(In Press Corrected Proof)
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12 January 2012 |
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Investigating channel blockers for the treatment of multiple sclerosis: Considerations with mefloquine and carbenoxolone
DOI: 10.1016/j.jneuroim.2011.12.016
I read with interest the recent article by describing inhibition of IL-23 expression by carbenoxolone. This article, together with earlier work demonstrating that carbenoxolone delayed onset of exper...
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Remington Lee Nevin
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Correspondence
(In Press Corrected Proof)
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11 January 2012 |
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Latent tuberculosis seems not to reactivate in multiple sclerosis patients on natalizumab
DOI: 10.1016/j.jneuroim.2011.12.009
Abstract: Current safety recommendations for multiple sclerosis (MS) patients who are considered for natalizumab do not specify how to screen for latent tuberculosis (LTB). Only chest X-ray is recomme...
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Patricia Mulero,
Ana Belén Caminero,
Ma José Neri Crespo,
Rosario Fernández-Herranz,
Nieves Téllez Lara
et al.
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Short communication
(In Press Corrected Proof)
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09 January 2012 |
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Serum levels of interleukin (IL)-18, IL-23 and IL-17 in Chinese patients with multiple sclerosis
DOI: 10.1016/j.jneuroim.2011.12.008
Abstract: It has been reported that cytokines play an important role in the pathogenesis of multiple sclerosis (MS). The aim of this study was to evaluate the serum levels of interleukin (IL)-18, IL-2...
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Ying-Chun Chen,
Sheng-Di Chen,
Ling Miao,
Zhen-Guo Liu,
Wei Li,
Zhong-Xin Zhao,
Xiao-Jiang Sun,
Guo-Xin Jiang,
Qi Cheng
et al.
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Full-length article
(In Press Corrected Proof)
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09 January 2012 |
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Divalent and monovalent autoantibodies cause dysfunction of MuSK by distinct mechanisms in a rabbit model of myasthenia gravis
DOI: 10.1016/j.jneuroim.2011.12.005
Abstract: Muscle-specific kinase (MuSK), a receptor tyrosine kinase, is required for the formation and maintenance of neuromuscular junctions (NMJs). Although autoantibodies against MuSK have been dem...
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Shuuichi Mori,
Shigeru Yamada,
Sachiho Kubo,
Jie Chen,
Seiji Matsuda,
Masachika Shudou,
Naoki Maruyama,
Kazuhiro Shigemoto
et al.
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Full-length article
(In Press Corrected Proof)
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06 January 2012 |
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Diurnal rhythms are altered in a mouse model of multiple sclerosis
DOI: 10.1016/j.jneuroim.2011.12.002
Abstract: Our earlier studies described a disruption of heart rate and blood pressure diurnal rhythms in mice with experimental autoimmune encephalomyelitis (EAE). The present study investigates wheth...
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Abigail C. Buenafe
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Full-length article
(In Press Corrected Proof)
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03 January 2012 |
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S100B modulates growth factors and costimulatory molecules expression in cultured human astrocytes
DOI: 10.1016/j.jneuroim.2011.11.011
Abstract: S100B is a Ca2+-binding protein expressed in the nervous system. Increased levels of S100B in the extracellular space have been detected in several neurological disorders. We investigated th...
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Camilla Reali,
Rita Pillai,
Francesca Saba,
Stefano Cabras,
Fabrizio Michetti,
Valeria Sogos
et al.
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Short communication
(In Press Corrected Proof)
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26 December 2011 |
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A role for inflammatory mediators in the modulation of the neurotrophin receptor p75NTR on human muscle precursor cells
DOI: 10.1016/j.jneuroim.2011.12.001
Abstract: The neurotrophin receptor p75NTR is a marker for human differentiation-prone muscle satellite cells and regulates myogenesis. Here, we wondered whether inflammation could modify p75NTR expre...
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Emanuela Colombo,
Stefania Romaggi,
Marina Mora,
Lucia Morandi,
Cinthia Farina
et al.
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Short communication
(In Press Corrected Proof)
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26 December 2011 |
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Investigation of autoantibody profiles for cerebrospinal fluid biomarker discovery in patients with relapsing–remitting multiple sclerosis
DOI: 10.1016/j.jneuroim.2011.08.013
Abstract: Using the UNIarray® marker technology platform, cerebrospinal fluid immunoglobulin G reactivities of 15 controls and 17 RRMS patients against human recombinant proteins were investigated. Pa...
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Natascha Helena Beyer,
Angelika Lueking,
Axel Kowald,
Jette Lautrup Frederiksen,
Niels H.H. Heegaard
et al.
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Full-length article
(In Press Corrected Proof)
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19 December 2011 |
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Plasma sCD28, sCTLA-4 levels in neuromyelitis optica and multiple sclerosis during relapse
DOI: 10.1016/j.jneuroim.2011.11.010
Abstract: Background: Soluble forms of CD28 (sCD28) and CTLA-4 (sCTLA-4) were associated with many autoimmune diseases like Sjögren's syndrome, systemic lupus erythematosus, asthma, and autoimmune mya...
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Honghao Wang,
Kai Wang,
Xiaonan Zhong,
Yongqiang Dai,
Aimin Wu,
Ying Li,
Xueqiang Hu
et al.
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Full-length article
(In Press Corrected Proof)
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19 December 2011 |
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Guillain–Barre syndrome: First description of a snake envenomation aetiology
DOI: 10.1016/j.jneuroim.2011.11.007
Abstract: Background: Guillain–Barre syndrome (GBS) is considered as an acute, immune-mediated polyradiculoneuropathy with different clinical phenotypes arising after viral or bacterial infections, va...
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Jean Neil,
Valérie Choumet,
Alain Le Coupanec,
Jacques d'Alayer,
Sophie Demeret,
Lucile Musset
et al.
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Full-length article
(In Press Corrected Proof)
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16 December 2011 |
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Neutrophils in multiple sclerosis are characterized by a primed phenotype
DOI: 10.1016/j.jneuroim.2011.11.009
Abstract: Neutrophils are armed with proteases with indiscriminate histotoxic potential, and to minimize tissue injury, their activation involves priming with inflammatory mediators before cells are f...
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Matthias Naegele,
Kati Tillack,
Stefanie Reinhardt,
Sven Schippling,
Roland Martin,
Mireia Sospedra
et al.
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Full-length article
(In Press Corrected Proof)
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12 December 2011 |
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Immune profiling of Alzheimer patients
DOI: 10.1016/j.jneuroim.2011.11.005
Abstract: Alzheimer's disease (AD) is characterized by extracellular senile plaques in the brain, containing amyloid-β peptide (Aβ). We identify immunological differences between AD patients and age-m...
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Mariavaleria Pellicanò,
Anis Larbi,
David Goldeck,
Giuseppina Colonna-Romano,
Silvio Buffa,
Matteo Bulati,
Graziella Rubino,
Francesco Iemolo,
Giuseppina Candore,
Calogero Caruso,
Evelyna Derhovanessian,
Graham Pawelec
et al.
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Full-length article
(In Press Corrected Proof)
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08 December 2011 |
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Synapsin peptide fused to E. coli heat-labile toxin B subunit induces regulatory T cells and modulates cytokine balance in experimental autoimmune encephalomyelitis
DOI: 10.1016/j.jneuroim.2011.11.006
Abstract: We previously found that the preventive oral administration of a hybrid consisting of the C domain of synapsin and the B subunit of E. coli heat-labile enterotoxin (LTBSC) efficiently suppre...
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M. Julia Scerbo,
Mario J. Bibolini,
German A. Roth,
Clara G. Monferran
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Full-length article
(In Press Corrected Proof)
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06 December 2011 |
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Proteomics technologies for biomarker discovery in multiple sclerosis
DOI: 10.1016/j.jneuroim.2011.11.004
Abstract: Multiple sclerosis is a disabling inflammatory and neurodegenerative disorder that predominantly affects young adults. There is a great need for biomarkers, which could elucidate pathology a...
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Vaibhav Singh,
Rogier Q. Hintzen,
Theo M. Luider,
Marcel P. Stoop
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Review article
(In Press Corrected Proof)
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02 December 2011 |
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The role of the Epstein–Barr Virus receptor CD21 in Multiple Sclerosis
DOI: 10.1016/j.jneuroim.2011.11.002
Abstract: Multiple Sclerosis (MS) is characterised by a chronic inflammation and demyelination of brain and spinal cord with a yet unknown aetiology. Based on multiple epidemiological and immunologica...
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Nicole Toepfner,
Sabine Cepok,
Verena Grummel,
Bernhard Hemmer
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Full-length article
(In Press Corrected Proof)
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02 December 2011 |
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Evidence of central inflammation in fibromyalgia — Increased cerebrospinal fluid interleukin-8 levels
DOI: 10.1016/j.jneuroim.2011.10.013
Abstract: Activation of glia cells resulting in intrathecal elevation of cytokines and chemokines has been hypothesized in chronic pain syndromes such as fibromyalgia. To our knowledge, this is the fi...
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Diana Kadetoff,
Jon Lampa,
Marie Westman,
Magnus Andersson,
Eva Kosek
et al.
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Full-length article
(In Press Corrected Proof)
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30 November 2011 |
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Publication guidelines for refereeing and reporting on animal use in experimental autoimmune encephalomyelitis
DOI: 10.1016/j.jneuroim.2011.11.003
Abstract: Experimental Autoimmune encephalomyelitis (EAE) is one of the major pre-clinical models of multiple sclerosis. Use of this model has led to some important observations that has benefited hum...
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David Baker,
Sandra Amor
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Short communication
(In Press Corrected Proof)
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28 November 2011 |
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Anti-glioma response of autologous T cells stimulated by autologous dendritic cells electrofused with CD133+ or CD133− glioma cells
DOI: 10.1016/j.jneuroim.2011.11.001
Abstract: Glioma, the most common tumor of the central nervous system (CNS), currently results in a high rate of morbidity and mortality. The expression of CD133, a stem-like cell marker expressed in ...
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Kun Qin,
Ge Tian,
Peng Li,
Qiang Chen,
Run Zhang,
Yi-quan Ke,
Zhi-cheng Xiao,
Xiao-dan Jiang
et al.
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Full-length article
(In Press Corrected Proof)
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28 November 2011 |
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Substance P–Neurokinin-1 receptor interaction upregulates monocyte tissue factor
DOI: 10.1016/j.jneuroim.2011.10.012
Abstract: Monocytes play an important role in hemostasis. In this study, the prothrombotic effects of the neuropeptide substance P (SP) on human monocytes through neurokinin-1 receptor (NK1-R) were ch...
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Mohammad M. Khan,
Steven D. Douglas,
Tami D. Benton
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Full-length article
(In Press Corrected Proof)
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24 November 2011 |
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IFN-β induces the proliferation of CD4+CD25+Foxp3+ regulatory T cells through upregulation of GITRL on dendritic cells in the treatment of multiple sclerosis
DOI: 10.1016/j.jneuroim.2011.10.014
Abstract: IFN-β is a major disease-modifying agent used for the treatment of multiple sclerosis (MS). Its mechanisms are complex and it has broad immunomodulatory effects on many types of immune cells...
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Meiyue Chen,
Guangjie Chen,
Shaohua Deng,
Xin Liu,
George J. Hutton,
Jian Hong
et al.
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Full-length article
(In Press Corrected Proof)
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23 November 2011 |
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miRNA profiling for biomarker discovery in multiple sclerosis: From microarray to deep sequencing
DOI: 10.1016/j.jneuroim.2011.10.006
Abstract: MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression at the post-transcriptional level. miRNAs are highly expressed in cells of the immune and nervous system, attesting...
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Mireia Guerau-de-Arellano,
Hansjuerg Alder,
Hatice Gulcin Ozer,
Amy Lovett-Racke,
Michael K. Racke
et al.
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Review article
(In Press Corrected Proof)
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11 November 2011 |
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Chemokines and chemokine receptors in the nervous system
DOI: 10.1016/j.jneuroim.2007.03.017
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Announcement
(In Press Corrected Proof)
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11 May 2007 |