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Exploring the role of the epigenome in multiple sclerosis: A window onto cell-specific transcriptional potential
02 February 2012
Anna Kaliszewska, Philip L. De Jager
Abstract: The field of epigenomics involves the study of chromatin, the three dimensional complex of DNA, protein and non-coding RNAs that determines the accessibility of DNA by the transcriptional ma...
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Repeated morphine treatment-mediated hyperalgesia, allodynia and spinal glial activation are blocked by co-administration of a selective cannabinoid receptor type-2 agonist
30 January 2012
Suneeta Tumati, Tally M. Largent-Milnes, Attila Keresztes, Jiyang Ren, William R. Roeske, Todd W. Vanderah, Eva V. Varga
Abstract: Spinal glial activation has been implicated in sustained morphine-mediated paradoxical pain sensitization. Since activation of glial CB2 cannabinoid receptors attenuates spinal glial activat...
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Next-generation sequencing approaches for genetic mapping of complex diseases
30 January 2012
Ferran Casals, Youssef Idaghdour, Julie Hussin, Philip Awadalla
Abstract: The advent of next generation sequencing technologies has opened new possibilities in the analysis of human disease. In this review we present the main next-generation sequencing technologie...
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Data integration and systems biology approaches for biomarker discovery: Challenges and opportunities for multiple sclerosis
27 January 2012
Pablo Villoslada, Sergio Baranzini
Abstract: New “omic” technologies and their application to systems biology approaches offer new opportunities for biomarker discovery in complex disorders, including multiple sclerosis (MS). Recent st...
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Key role of CXCL13/CXCR5 axis for cerebrospinal fluid B cell recruitment in pediatric OMS
24 January 2012
Michael R. Pranzatelli, Elizabeth D. Tate, Nathan R. McGee, Anna L. Travelstead, Richard M. Ransohoff, Jayne M. Ness, Jerry A. Colliver
Abstract: To study aberrant B cell trafficking into the CSF in opsoclonus–myoclonus syndrome (OMS), chemoattractants CXCL13 and CXCL12, and B cell frequency and CXCR5 expression, were evaluated. CSF C...
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