Journal of Neuroimmunology
Volume 229, Issue 1 , Pages 140-145 , 15 December 2010

Low dose combination steroids control autoimmune mouse hearing loss

Received 12 May 2010 ,Accepted 27 July 2010.

References 

  1. Alexiou C, Arnold W, Fauser C, Schratzenstaller B, Gloddek B, Fuhrmann S, et al. Sudden sensorineural hearing loss: does application of glucocorticoids make sense?. Arch. Otolaryngol. Head Neck Surg. 2001;127:253–258
  2. Aoki D, Takegoshi H, Kikuchi S. Evaluation of super-high-dose steroid therapy for sudden sensorineural hearing loss. Otolaryngol. Head Neck Surg. 2006;134:783–787
  3. Barna BP, Hughes GB. Autoimmune inner ear disease — a real entity?. Clin. Lab. Med. 1997;17:581–594
  4. Barrs DM. Intratympanic corticosteroids for Meniere's disease and vertigo. Otolaryngol. Clin. North Am. 2004;37:955–972v
  5. Couloigner V, Sterkers O, Ferrary E. What's new in ion transports in the cochlea?. Pflugers Arch. 2006;453:11–22
  6. Dornhoffer JL, Arenberg JG, Arenberg IK, Shambaugh GE. Pathophysiological mechanisms in immune inner ear disease. Acta Otolaryngol. Suppl. 1997;526:30–36
  7. Funder JW. Glucocorticoid and mineralocorticoid receptors: biology and clinical relevance. Annu. Rev. Med. 1997;48:231–240
  8. Garcia-Berrocal JR, Ramirez-Camacho R. Sudden sensorineural hearing loss: supporting the immunologic theory. Ann. Otol. Rhinol. Laryngol. 2002;111:989–997
  9. Harris JP, Ryan AF. Fundamental immune mechanisms of the brain and inner ear. Otolaryngol. Head Neck Surg. 1995;112:639–653
  10. Hellier WP, Wagstaff SA, O'Leary SJ, Shepherd RK. Functional and morphological response of the stria vascularis following a sensorineural hearing loss. Hear. Res. 2002;172:127–136
  11. Henkin RI, Daly RL. Auditory detection and perception in normal man and in patients with adrenal cortical insufficiency: effect of adrenal cortical steroids. J. Clin. Invest. 1968;47:1269–1280
  12. Henkin RI, McGlone RE, Daly R, Bartter FC. Studies on auditory thresholds in normal man and in patients with adrenal cortical insufficiency: the role of adrenal cortical steroids. J. Clin. Invest. 1967;46:429–435
  13. Kim SH, Kim KX, Raveendran NN, Wu T, Pondugula SR, Marcus DC. Regulation of ENaC-mediated sodium transport by glucocorticoids in Reissner's membrane epithelium. Am. J. Physiol. Cell Physiol. 2009;296:C544–C557
  14. Kim SH, Marcus DC. Endolymphatic sodium homeostasis by extramacular epithelium of the saccule. J. Neurosci. 2009;29:15851–15858
  15. Lang F, Bohmer C, Palmada M, Seebohm G, Strutz-Seebohm N, Vallon V. (Patho)physiological significance of the serum- and glucocorticoid-inducible kinase isoforms. Physiol. Rev. 2006;86:1151–1178
  16. Lang F, Vallon V, Knipper M, Wangemann P. Functional significance of channels and transporters expressed in the inner ear and kidney. Am. J. Physiol. Cell Physiol. 2007;293:C1187–C1208
  17. Lee JH, Marcus DC. Nongenomic effects of corticosteroids on ion transport by stria vascularis. Audiol. Neurootol. 2002;7:100–106
  18. Lin DW, Trune DR. Breakdown of stria vascularis blood-labyrinth barrier in C3H/lpr autoimmune disease mice. Otolaryngol. Head Neck Surg. 1997;117:530–534
  19. Loveman DM, de Comarmond C, Cepero R, Baldwin DM. Autoimmune sensorineural hearing loss: clinical course and treatment outcome. Semin. Arthritis Rheum. 2004;34:538–543
  20. Mathews J, Kumar BN. Autoimmune sensorineural hearing loss. Clin. Otolaryngol. Allied Sci. 2003;28:479–488
  21. Mitchell CR, Kempton JB, Creedon TA, Trune DR. The use of a 56-stimulus train for the rapid acquisition of auditory brainstem responses. Audiol. Neurootol. 1999;4:80–87
  22. Nadel, D. M. 1996. The use of systemic steroids in otolaryngology. Ear Nose Throat J. 75, 502–505, 509–510, 511–502 passim.
  23. Niparko JK, Wang NY, Rauch SD, Russell GB, Espeland MA, Pierce JJ, et al. Serial audiometry in a clinical trial of AIED treatment. Otol. Neurotol. 2005;26:908–917
  24. Pondugula SR, Sanneman JD, Wangemann P, Milhaud PG, Marcus DC. Glucocorticoids stimulate cation absorption by semicircular canal duct epithelium via epithelial sodium channel. Am. J. Physiol. Ren. Physiol. 2004;286:F1127–F1135
  25. Rauch SD. Intratympanic steroids for sensorineural hearing loss. Otolaryngol. Clin. North Am. 2004;37:1061–1074
  26. Ruckenstein MJ, Milburn M, Hu L. Strial dysfunction in the MRL-Fas mouse. Otolaryngol. Head Neck Surg. 1999;121:452–456
  27. Rupprecht R, Reul JM, van Steensel B, Spengler D, Soder M, Berning B, et al. Pharmacological and functional characterization of human mineralocorticoid and glucocorticoid receptor ligands. Eur. J. Pharmacol. 1993;247:145–154
  28. Schimmer, B. P. Parker, K. L. (2006). Adrenocorticotropic hormone; adrenocortical steroids and their synthetic analogs; inhibitors of the synthesis and actions of adrenocortical hormones. Goodman and Gilman's The Pharmacological Basis of Therapeutics. L. L. Brunton, Lazo, J.S., Parker, K.L. New York, McGraw-Hill 1587–1612.
  29. Schuetz F, Kumar S, Poronnik P, Adams DJ. Regulation of the voltage-gated K(+) channels KCNQ2/3 and KCNQ3/5 by serum- and glucocorticoid-regulated kinase-1. Am. J. Physiol. Cell Physiol. 2008;295:C73–C80
  30. Sismanis A, Wise CM, Johnson GD. Methotrexate management of immune-mediated cochleovestibular disorders. Otolaryngol. Head Neck Surg. 1997;116:146–152
  31. Tadros SF, Frisina ST, Mapes F, Frisina DR, Frisina RD. Higher serum aldosterone correlates with lower hearing thresholds: a possible protective hormone against presbycusis. Hear. Res. 2005;209:10–18
  32. Trune DR. Cochlear immunoglobulin in the C3H/lpr mouse model for autoimmune hearing loss. Otolaryngol. Head Neck Surg. 1997;117:504–508
  33. Trune DR, Kempton JB. Aldosterone and prednisolone control of cochlear function in MRL/MpJ-Fas(lpr) autoimmune mice. Hear. Res. 2001;155:9–20
  34. Trune DR, Kempton JB. Blocking the glucocorticoid receptor with RU-486 does not prevent glucocorticoid control of autoimmune mouse hearing loss. Audiol. Neurootol. 2009;14:423–431
  35. Trune DR, Kempton JB, Gross ND. Mineralocorticoid receptor mediates glucocorticoid treatment effects in the autoimmune mouse ear. Hear. Res. 2006;212:22–32
  36. Trune DR, Kempton JB, Harrison AR, Wobig JL. Glucocorticoid impact on cochlear function and systemic side effects in autoimmune C3.MRL-Faslpr and normal C3H/HeJ mice. Hear. Res. 2007;226:209–217
  37. Yehudai D, Shoenfeld Y, Toubi E. The autoimmune characteristics of progressive or sudden sensorineural hearing loss. Autoimmunity. 2006;39:153–158

PII: S0165-5728(10)00339-5

doi: 10.1016/j.jneuroim.2010.07.026

Journal of Neuroimmunology
Volume 229, Issue 1 , Pages 140-145 , 15 December 2010