Journal of Neuroimmunology
Volume 230, Issue 1 , Pages 183-187 , January 2011

Photoreceptor cells constitutively express functional TLR4

  • Zhidan Tu

      Affiliations

    • Department of Pathology, Case Western Reserve University, Cleveland, USA
    • Department of Pathology, Sichuan University, Chengdu, China
    • ,
  • Jose-Andres C. Portillo

      Affiliations

    • Department of Medicine, Case Western Reserve University, Cleveland, USA
    • ,
  • Scott Howell

      Affiliations

    • Department of Ophthalmology, Case Western Reserve University, Cleveland, USA
    • ,
  • Hong Bu

      Affiliations

    • Department of Pathology, Sichuan University, Chengdu, China
    • ,
  • Carlos S. Subauste

      Affiliations

    • Department of Medicine, Case Western Reserve University, Cleveland, USA
    • ,
  • Muayyad R. Al-Ubaidi

      Affiliations

    • Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA
    • ,
  • Eric Pearlman

      Affiliations

    • Department of Ophthalmology, Case Western Reserve University, Cleveland, USA
    • ,
  • Feng Lin

      Affiliations

    • Department of Pathology, Case Western Reserve University, Cleveland, USA
    • Corresponding Author InformationCorresponding author. Institute of Pathology, Case Western Reserve University School of Medicine, 2085 Adelbert Road, Room 306, Cleveland, OH 44106, USA. Tel.: +1 216 368 2118.

Received 19 May 2010 ,Revised 23 July 2010 ,Accepted 27 July 2010.

References 

  1. Bissonnette CJ, Klegeris A, McGeer PL, McGeer EG. Interleukin 1alpha and interleukin 6 protect human neuronal SH-SY5Y cells from oxidative damage. Neurosci. Lett. 2004;361:40–43
  2. Chong DY, Boehlke CS, Zheng QD, Zhang L, Han Y, Zacks DN. Interleukin-6 as a photoreceptor neuroprotectant in an experimental model of retinal detachment. Invest. Ophthalmol Vis. Sci. 2008;49:3193–3200
  3. Kindzelskii AL, Elner VM, Elner SG, Yang D, Hughes BA, Petty HR. Toll-like receptor 4 (TLR4) of retinal pigment epithelial cells participates in transmembrane signaling in response to photoreceptor outer segments. J. Gen. Physiol. 2004;124:139–149
  4. Li X, Jiang S, Tapping RI. Toll-like receptor signaling in cell proliferation and survival. Cytokine. Neurosci. Lett. 2010;49:1–9
  5. Okun E, Griffioen KJ, Lathia JD, Tang SC, Mattson MP, Arumugam TV. Toll-like receptors in neurodegeneration. Brain Res. Rev. 2009;59:278–292
  6. Park JS, Gamboni-Robertson F, He Q, Svetkauskaite D, Kim JY, Strassheim D, et al. High mobility group box 1 protein interacts with multiple Toll-like receptors. Am. J. Physiol. Cell Physiol. 2006;290:C917–C924
  7. Peng YP, Qiu YH, Lu JH, Wang JJ. Interleukin-6 protects cultured cerebellar granule neurons against glutamate-induced neurotoxicity. Neurosci. Lett. 2005;374:192–196
  8. Poltorak A, He X, Smirnova I, Liu MY, Van Huffel C, Du X, et al. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science. 1998;282:2085–2088
  9. Portillo JA, Okenka G, Kern TS, Subauste CS. Identification of primary retinal cells and ex vivo detection of proinflammatory molecules using flow cytometry. Mol. Vis. 2009;15:1383–1389
  10. Sun Y, Pearlman E. Inhibition of corneal inflammation by the TLR4 antagonist Eritoran tetrasodium (E5564). Invest. Ophthalmol Vis. Sci. 2009;50:1247–1254
  11. Tan E, Ding XQ, Saadi A, Agarwal N, Naash MI, Al-Ubaidi MR. Expression of cone-photoreceptor-specific antigens in a cell line derived from retinal tumors in transgenic mice. Invest. Ophthalmol Vis. Sci. 2004;45:764–768
  12. Termeer C, Benedix F, Sleeman J, Fieber C, Voith U, Ahrens T, et al. Oligosaccharides of Hyaluronan activate dendritic cells via toll-like receptor 4. J. Exp. Med. 2002;195:99–111
  13. Ueki Y, Wang J, Chollangi S, Ash JD. STAT3 activation in photoreceptors by leukemia inhibitory factor is associated with protection from light damage. J. Neurochem. 2008;105:784–796

PII: S0165-5728(10)00335-8

doi: 10.1016/j.jneuroim.2010.07.022

Journal of Neuroimmunology
Volume 230, Issue 1 , Pages 183-187 , January 2011

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