Journal of Neuroimmunology
Volume 229, Issue 1 , Pages 219-224 , 15 December 2010

Qualitative and quantitative evidence of anti-glutamic acid decarboxylase-specific intrathecal antibody synthesis in patients with stiff person syndrome

  • S. Jarius

      Affiliations

    • Division of Clinical Neuroimmunology, Department of Neurology, University of Heidelberg, Heidelberg, Germany
    • Contributed equally.
    • ,
  • O. Stich

      Affiliations

    • Department of Neurology, Albert Ludwigs University, Freiburg, Germany
    • Contributed equally.
    • ,
  • J. Speck

      Affiliations

    • Department of Neurology, Albert Ludwigs University, Freiburg, Germany
    • ,
  • Ch. Rasiah

      Affiliations

    • ravo Diagnostika GmbH, Oltmannsstr. 5, D-79100 Freiburg, Germany
    • ,
  • B. Wildemann

      Affiliations

    • Division of Clinical Neuroimmunology, Department of Neurology, University of Heidelberg, Heidelberg, Germany
    • ,
  • H.M. Meinck

      Affiliations

    • Division of Clinical Neurophysiology, Department of Neurology, University of Heidelberg, Heidelberg, Germany
    • ,
  • S. Rauer

      Affiliations

    • Department of Neurology, Albert Ludwigs University, Freiburg, Germany
    • ravo Diagnostika GmbH, Oltmannsstr. 5, D-79100 Freiburg, Germany
    • Corresponding Author InformationCorresponding author. Department of Neurology, Albert Ludwigs University, Freiburg, Breisacher Strasse 64, D-79106 Freiburg, Germany. Tel.: +49 761 270 5001; fax: +49 761 270 5024.

Received 20 November 2009 ,Revised 7 May 2010 ,Accepted 22 July 2010.

References 

  1. Antoine JC, Absi L, Honnorat J, Boulesteix JM, de Brouker T, Vial C, et al. Antiamphiphysin antibodies are associated with various paraneoplastic neurological syndromes and tumors. Arch. Neurol. 1999;56:172–177
  2. Dalakas MC, Li M, Fujii M, Jacobowitz DM. Stiff person syndrome: quantification, specificity, and intrathecal synthesis of GAD65 antibodies. Neurology. 2001;57:780–784
  3. Dinkel K, Meinck HM, Jury KM, Karges W, Richter W. Inhibition of gamma-aminobutyric acid synthesis by glutamic acid decarboxylase autoantibodies in stiff-man syndrome. Ann. Neurol. 1998;44:194–201
  4. Felgenhauer K, Reiber H. The diagnostic significance of antibody specificity indices in multiple sclerosis and herpes virus induced diseases of the nervous system. Clin. Investig. 1992;70:28–37
  5. Folli F, Solimena M, Cofiell R, Austoni M, Tallini G, Fassetta G, et al Autoantibodies to a 128-kd synaptic protein in three women with the stiff-man syndrome and breast cancer. N Engl J. Med. 1993;328:546–551
  6. Ishida K, Mitoma H, Song SY, Uchihara T, Inaba A, Eguchi S, et al. Selective suppression of cerebellar GABAergic transmission by an autoantibody to glutamic acid decarboxylase. Ann. Neurol. 1999;46:263–267
  7. Jarius S, Stich O, Rasiah C, Voltz R, Rauer S. Qualitative evidence of Ri specific IgG-synthesis in the cerebrospinal fluid from patients with paraneoplastic neurological syndromes. J. Neurol. Sci. 2008;268:65–68
  8. Koerner C, Wieland B, Richter W, Meinck HM. Stiff-person syndromes: motor cortex hyperexcitability correlates with anti-GAD autoimmunity. Neurology. 2004;62:1357–1362
  9. Levy LM, Dalakas MC, Floeter MK. The stiff-person syndrome: an autoimmune disorder affecting neurotransmission of gamma-aminobutyric acid. Ann. Intern. Med. 1999;131:522–530
  10. Link H, Tibbling G. Principles of albumin and IgG analyses in neurological disorders. III. Evaluation of IgG synthesis within the central nervous system in multiple sclerosis. Scand J Clin Lab Invest. 1977;37:397–401
  11. Manto MU, Laute MA, Aguera M, Rogemond V, Pandolfo M, Honnorat J. Effects of anti-glutamic acid decarboxylase antibodies associated with neurological diseases. Ann. Neurol. 2007;61:544–551
  12. Meinck HM, Thompson PD. Stiff man syndrome and related conditions. Mov. Disord. 2002;17:853–866
  13. Meinck HM, Faber L, Morgenthaler N, Seissler J, Maile S, Butler M, et al. Antibodies against glutamic acid decarboxylase: prevalence in neurological diseases. J. Neurol. Neurosurg. Psychiatry. 2001;71:100–103
  14. Rakocevic G, Raju R, Dalakas MC. Anti-glutamic acid decarboxylase antibodies in the serum and cerebrospinal fluid of patients with stiff-person syndrome: correlation with clinical severity. Arch. Neurol. 2004;61:902–904
  15. Rauer S, Kaiser R. Demonstration of anti-HuD specific oligoclonal bands in the cerebrospinal fluid from patients with paraneoplastic neurological syndromes. Qualitative evidence of anti-HuD specific IgG-synthesis in the central nervous system. J. Neuroimmunol. 2000;111:241–244
  16. Rauer S, Kaiser R. Enzyme linked immunosorbent assay using recombinant HuD-autoantigen for serodiagnosis of paraneoplastic neurological syndromes. Acta Neurol. Scand. 2001;103:248–254
  17. Reiber H. Cerebrospinal fluid—physiology, analysis and interpretation of protein patterns for diagnosis of neurological diseases. Mult. Scler. 1998;4:99–107
  18. Reiber H, Peter JB. Cerebrospinal fluid analysis: disease-related data patterns and evaluation programs. J. Neurol. Sci. 2001;184:101–122
  19. Reiber H, Ungefehr S, Jacobi C. The intrathecal, polyspecific and oligoclonal immune response in multiple sclerosis. Mult. Scler. 1998;4:111–117
  20. Solimena M, Folli F, Aparisi R, Pozza G, De Camilli P. Autoantibodies to GABA-ergic neurons and pancreatic beta cells in stiff-man syndrome. N Engl J. Med. 1990;322:1555–1560
  21. Stich O, Rauer S. Qualitative evidence of anti-Ri specific intrathecal antibody synthesis and quantification of anti-Ri antibodies in serial samples from a patient with anti-Ri syndrome. J. Neurol. Neurosurg. Psychiatry. 2006;77:282–283
  22. Stich O, Rauer S. Antigen-specific oligoclonal bands in cerebrospinal fluid and serum from patients with anti-amphiphysin- and anti-CV2/CRMP5 associated paraneoplastic neurological syndromes. Eur. J. Neurol. 2007;14:650–653
  23. Stich O, Graus F, Rasiah C, Rauer S. Qualitative evidence of anti-Yo-specific intrathecal antibody synthesis in patients with paraneoplastic cerebellar degeneration. J. Neuroimmunol. 2003;141:165–169
  24. Stich O, Jarius S, Kleer B, Rasiah C, Voltz R, Rauer S. Specific antibody index in cerebrospinal fluid from patients with central and peripheral paraneoplastic neurological syndromes. J. Neuroimmunol. 2007;183:220–224
  25. Vincent A, Grimaldi LM, Martino G, Davenport C, Todd I. Antibodies to 125I-glutamic acid decarboxylase in patients with stiff man syndrome. J. Neurol. Neurosurg. Psychiatry. 1997;62:395–397
  26. Walikonis JE, Lennon VA. Radioimmunoassay for glutamic acid decarboxylase (GAD65) autoantibodies as a diagnostic aid for stiff-man syndrome and a correlate of susceptibility to type 1 diabetes mellitus. Mayo Clin. Proc. 1998;73:1161–1166

PII: S0165-5728(10)00332-2

doi: 10.1016/j.jneuroim.2010.07.019

Journal of Neuroimmunology
Volume 229, Issue 1 , Pages 219-224 , 15 December 2010

Article Tools

* Image Usage & Resolution