Journal of Neuroimmunology
Volume 227, Issue 1 , Pages 185-189, 8 October 2010

Bone marrow mesenchymal stem cell transplantation in patients with multiple sclerosis: A pilot study☆

  • Bassem Yamout

      Affiliations

    • Departments of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon
    • Corresponding Author InformationCorresponding author. Multiple Sclerosis Clinic and Research Center, Doctors' Center, 3rd Floor, Cairo St, near AUH, Beirut, Lebanon. Tel.: +961 1 344042; fax: +961 1 751517.
    • ,
  • Roula Hourani

      Affiliations

    • Departments of Radiology, American University of Beirut Medical Center, Beirut, Lebanon
    • ,
  • Haytham Salti

      Affiliations

    • Departments of Ophthalmology, American University of Beirut Medical Center, Beirut, Lebanon
    • ,
  • Wissam Barada

      Affiliations

    • Departments of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon
    • Current Address: Department of Internal Medicine at International Medical Center in Jeddah, KSA.
    • ,
  • Taghrid El-Hajj

      Affiliations

    • Departments of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon
    • Current Address: Department of Internal Medicine at Al Rasoul Hospital, Beirut, Lebanon.
    • ,
  • Aghiad Al-Kutoubi

      Affiliations

    • Departments of Radiology, American University of Beirut Medical Center, Beirut, Lebanon
    • ,
  • Aline Herlopian

      Affiliations

    • Departments of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon
    • ,
  • Elizabeth Kfoury Baz

      Affiliations

    • Departments of Pathology and Laboratory Medicine, American University of Beirut Medical Center, Beirut, Lebanon
    • ,
  • Rami Mahfouz

      Affiliations

    • Departments of Pathology and Laboratory Medicine, American University of Beirut Medical Center, Beirut, Lebanon
    • ,
  • Rima Khalil-Hamdan

      Affiliations

    • Departments of Pathology and Laboratory Medicine, American University of Beirut Medical Center, Beirut, Lebanon
    • ,
  • Nabeela M.A. Kreidieh

      Affiliations

    • Departments of Pathology and Laboratory Medicine, American University of Beirut Medical Center, Beirut, Lebanon
    • ,
  • Marwan El-Sabban

      Affiliations

    • Departments of Human Morphology, American University of Beirut Medical Center, Beirut, Lebanon
    • ,
  • Ali Bazarbachi

      Affiliations

    • Departments of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon

Received 10 May 2010; received in revised form 12 July 2010; accepted 19 July 2010. published online 23 August 2010.

Abstract 

We explore the safety, and therapeutic benefit of intrathecal injection of ex-vivo expanded autologous bone marrow derived mesenchymal stem cells (BM-MSCs) in 10 patients with advanced multiple sclerosis (MS). Patients were assessed at 3, 6 and 12months. Assessment at 3–6months revealed Expanded Disability Scale Score (EDSS) improvement in 5/7, stabilization in 1/7, and worsening in 1/7 patients. MRI at 3months revealed new or enlarging lesions in 5/7 and Gadolinium (Gd+) enhancing lesions in 3/7 patients. Vision and low contrast sensitivity testing at 3months showed improvement in 5/6 and worsening in 1/6 patients. Early results show hints of clinical but not radiological efficacy and evidence of safety with no serious adverse events.

Keyword: Mesenchymal stem cells, Autologous, Intrathecal, Multiple sclerosis, Magnetic resonance imaging, Optical coherence tomography, Expanded disability status scale

To access this article, please choose from the options below

Login to an existing account or Register a new account.

  • Purchase this article for 31.50 USD (You must login/register to purchase this article)

    Online access for 24 hours. The PDF version can be downloaded as your permanent record.

  • Subscribe to this title

    Get unlimited online access to this article and all other articles in this title 24/7 for one year.

  • Claim access now

    For current subscribers with Society Membership or Account Number.

  • Visit SciVerse ScienceDirect to see if you have access via your institution.
 

☆ This study was funded by intramural grants as well as grants from the “Azem and Saadeh” non-profit Lebanese organization. The university provided the equipment which is part of their property.

PII: S0165-5728(10)00326-7

doi:10.1016/j.jneuroim.2010.07.013

Journal of Neuroimmunology
Volume 227, Issue 1 , Pages 185-189, 8 October 2010

Article Tools

* Image Usage & Resolution