Binding of recombinant T cell receptor ligands (RTL) to antigen presenting cells prevents upregulation of CD11b and inhibits T cell activation and transfer of experimental autoimmune encephalomyelitis

Sinha, Sushmita; Miller, Lisa; Subramanian, Sandhya; McCarty, Owen J.T.; Proctor, Thomas; Meza-Romero, Roberto; Huan, Jianya; Burrows, Gregory G.; Vandenbark, Arthur A.; Offner, Halina

doi:10.1016/j.jneuroim.2010.04.013

« Previous Next »Journal of Neuroimmunology
Volume 225, Issue 1 , Pages 52-61, 25 August 2010

Binding of recombinant T cell receptor ligands (RTL) to antigen presenting cells prevents upregulation of CD11b and inhibits T cell activation and transfer of experimental autoimmune encephalomyelitis

Sushmita Sinha
- Neuroimmunology Research R&D-31, Portland V.A. Medical Center, 3710 SW US Veterans Hospital Rd., Portland, OR 97239, United States
- Department of Neurology, Oregon Health & Science University, Portland, OR 97239, United States
Lisa Miller
- Neuroimmunology Research R&D-31, Portland V.A. Medical Center, 3710 SW US Veterans Hospital Rd., Portland, OR 97239, United States
Sandhya Subramanian
- Neuroimmunology Research R&D-31, Portland V.A. Medical Center, 3710 SW US Veterans Hospital Rd., Portland, OR 97239, United States
Owen J.T. McCarty
- Department of Biomedical Engineering, Oregon Health & Science University, Portland, OR 97239, United States
Thomas Proctor
- Neuroimmunology Research R&D-31, Portland V.A. Medical Center, 3710 SW US Veterans Hospital Rd., Portland, OR 97239, United States
- Tykeson MS Research Laboratory, Oregon Health & Science University, Portland, OR 97239, United States
Roberto Meza-Romero
- Neuroimmunology Research R&D-31, Portland V.A. Medical Center, 3710 SW US Veterans Hospital Rd., Portland, OR 97239, United States
- Department of Neurology, Oregon Health & Science University, Portland, OR 97239, United States
- Tykeson MS Research Laboratory, Oregon Health & Science University, Portland, OR 97239, United States
Jianya Huan
- Department of Neurology, Oregon Health & Science University, Portland, OR 97239, United States
- Tykeson MS Research Laboratory, Oregon Health & Science University, Portland, OR 97239, United States
Gregory G. Burrows
- Department of Neurology, Oregon Health & Science University, Portland, OR 97239, United States
- Department of Biochemistry and Molecular Biology, Oregon Health & Science University, Portland, OR 97239, United States
- Tykeson MS Research Laboratory, Oregon Health & Science University, Portland, OR 97239, United States
Arthur A. Vandenbark
- Neuroimmunology Research R&D-31, Portland V.A. Medical Center, 3710 SW US Veterans Hospital Rd., Portland, OR 97239, United States
- Department of Neurology, Oregon Health & Science University, Portland, OR 97239, United States
- Department of Molecular Microbiology and Immunology, Oregon Health & Science University, Portland, OR 97239, United States
- Tykeson MS Research Laboratory, Oregon Health & Science University, Portland, OR 97239, United States
- Contributed equally to this work.
Halina Offner
- Neuroimmunology Research R&D-31, Portland V.A. Medical Center, 3710 SW US Veterans Hospital Rd., Portland, OR 97239, United States
- Department of Neurology, Oregon Health & Science University, Portland, OR 97239, United States
- Department of Anesthesiology and Perioperative Medicine, Oregon Health & Science University, Portland, OR 97239, United States
- Tykeson MS Research Laboratory, Oregon Health & Science University, Portland, OR 97239, United States
- Corresponding author. Neuroimmunology Research R&D-31, Portland V.A. Medical Center, 3710 SW US Veterans Hospital Rd., Portland, OR 97239, United States. Tel.: +1 503 721 7893; fax: +1 503 721 7975.
- Contributed equally to this work.