Journal of Neuroimmunology
Volume 225, Issue 1 , Pages 34-42 , 25 August 2010

Cytotoxic T-lymphocytes secrete soluble factors that induce caspase-mediated apoptosis in glioblastoma cell lines

  • Alberto Cagigi

      Affiliations

    • Department of Laboratory Medicine, Division of Clinical Immunology, Karolinska University Hospital Huddinge, Alfred Nobels Allé 8, S 141 86 Stockholm, Sweden
    • Corresponding Author InformationCorresponding author. Tel.: +46 0046739926078.
    • Equally contributing authors.
    • ,
  • Anna Nilsson

      Affiliations

    • Dept of Women and Child Health, Karolinska Institutet, Astrid Lindgrens Children Hospital, Stockholm, Sweden
    • Equally contributing authors.
    • ,
  • Victor Levitsky

      Affiliations

    • Oncology Department, Johns Hopkins University School of Medicine, Baltimore, USA
    • ,
  • Farideh Sabri

      Affiliations

    • Institute of Environmental Medicine, Division of Toxicology and Neurotoxicology, Karolinska Institutet, Stockholm, Sweden

Received 22 December 2009 ,Revised 13 April 2010 ,Accepted 14 April 2010.

References 

  1. Baptiste-Okoh N, Barsotti AM, Prives C. Caspase 2 is both required for p53-mediated apoptosis and downregulated by p53 in a p21-dependent manner. Cell Cycle. 2008;7:1133–1138
  2. Baptiste-Okoh N, Barsotti AM, Prives C. A role for caspase 2 and PIDD in the process of p53-mediated apoptosis. Proc. Natl Acad. Sci. USA. 2008;105:1937–1942
  3. Borges HL, Linden R, Wang JY. DNA damage-induced cell death: lessons from the central nervous system. Cell Res. 2008;18:17–26
  4. Chowdhury I, Tharakan B, Bhat GK. Current concepts in apoptosis: the physiological suicide program revisited. Cell Mol. Biol. Lett. 2006;11:506–525
  5. De Geer A, Kiessling R, Levitsky V, Levitskaya J. Cytotoxic T lymphocytes induce caspase-dependent and -independent cell death in neuroblastomas in a MHC-nonrestricted fashion. J. Immunol. 2006;177:7540–7550
  6. Degterev A, Yuan J. Expansion and evolution of cell death programmes. Nat. Rev. Mol. Cell Biol. 2008;9:378–390
  7. Ekert PG, Silke J, Vaux DL. Caspase inhibitors. Cell Death Differ. 1999;6:1081–1086
  8. Elovaara I, Sabri F, Gray F, Alafuzoff I, Chiodi F. Upregulated expression of Fas and Fas ligand in brain through the spectrum of HIV-1 infection. Acta Neuropathol. (Berl). 1999;98:355–362
  9. Falsig J, Latta M, Leist M. Defined inflammatory states in astrocyte cultures: correlation with susceptibility towards CD95-driven apoptosis. J. Neurochem. 2004;88:181–193
  10. Furnari FB, Fenton T, Bachoo RM, Mukasa A, Stommel JM, Stegh A, et al. Malignant astrocytic glioma: genetics, biology, and paths to treatment. Genes Dev. 2007;21:2683–2710
  11. Lenardo M, Chan KM, Hornung F, McFarland H, Siegel R, Wang J, et al. Mature T lymphocyte apoptosis—immune regulation in a dynamic and unpredictable antigenic environment. Annu. Rev. Immunol. 1999;17:221–253
  12. Levitsky V, de Campos-Lima PO, Frisan T, Masucci MG. The clonal composition of a peptide-specific oligoclonal CTL repertoire selected in response to persistent EBV infection is stable over time. J. Immunol. 1998;161:594–601
  13. Maianski NA, Roos D, Kuijpers TW. Tumor necrosis factor alpha induces a caspase-independent death pathway in human neutrophils. Blood. 2003;101:1987–1995
  14. Major EO, Vacante DA. Human fetal astrocytes in culture support the growth of the neurotropic human polyomavirus, JCV. J. Neuropathol. Exp. Neurol. 1989;48:425–436
  15. Marten NW, Stohlman SA, Bergmann CC. Role of viral persistence in retaining CD8(+) T cells within the central nervous system. J. Virol. 2000;74:7903–7910
  16. Mullbacher A, Lobigs M, Hla RT, Tran T, Stehle T, Simon MM. Antigen-dependent release of IFN-gamma by cytotoxic T cells up-regulates Fas on target cells and facilitates exocytosis-independent specific target cell lysis. J. Immunol. 2002;169:145–150
  17. Naruse I, Keino H. Apoptosis in the developing CNS. Prog. Neurobiol. 1995;47:135–155
  18. Oue T, Fukuzawa M, Kusafuka T, Kohmoto Y, Imura K, Nagahara S, et al. In situ detection of DNA fragmentation and expression of bcl-2 in human neuroblastoma: relation to apoptosis and spontaneous regression. J. Pediatr. Surg. 1996;31:251–257
  19. Pollack IF, Erff M, Ashkenazi A. Direct stimulation of apoptotic signaling by soluble Apo2l/tumor necrosis factor-related apoptosis-inducing ligand leads to selective killing of glioma cells. Clin. Cancer Res. 2001;7:1362–1369
  20. Rabin H, Hopkins RF, Ruscetti FW, Neubauer RH, Brown RL, Kawakami TG. Spontaneous release of a factor with properties of T cell growth factor from a continuous line of primate tumor T cells. J. Immunol. 1981;127:1852–1856
  21. Rickert CH. Epidemiological features of brain tumors in the first 3years of life. Childs Nerv. Syst. 1998;14:547–550
  22. Rieger J, Naumann U, Glaser T, Ashkenazi A, Weller M. APO2 ligand: a novel lethal weapon against malignant glioma?. FEBS Lett. 1998;427:124–128
  23. Sabri F, Chiodi F, Piret JP, Wei CH, Major E, Westermark B, et al. Soluble factors released by virus specific activated cytotoxic T-lymphocytes induce apoptotic death of astroglioma cell lines. Brain Pathol. 2003;13:165–175
  24. Shresta S, Pham CT, Thomas DA, Graubert TA, Ley TJ. How do cytotoxic lymphocytes kill their targets?. Curr. Opin. Immunol. 1998;10:581–587
  25. Sidoti-de Fraisse C, Rincheval V, Risler Y, Mignotte B, Vayssiere JL. TNF-alpha activates at least two apoptotic signaling cascades. Oncogene. 1998;17:1639–1651
  26. Sonoda Y, Ozawa T, Hirose Y, Aldape KD, McMahon M, Berger MS, et al. Formation of intracranial tumors by genetically modified human astrocytes defines four pathways critical in the development of human anaplastic astrocytoma. Cancer Res. 2001;61:4956–4960
  27. Sprick MR, Rieser E, Stahl H, Grosse-Wilde A, Weigand MA, Walczak H. Caspase-10 is recruited to and activated at the native TRAIL and CD95 death-inducing signalling complexes in a FADD-dependent manner but can not functionally substitute caspase-8. Embo J. 2002;21:4520–4530
  28. Stegh AH, Kim H, Bachoo RM, Forloney KL, Zhang J, Schulze H, et al. Bcl2L12 inhibits post-mitochondrial apoptosis signaling in glioblastoma. Genes Dev. 2007;21:98–111
  29. Strickler R, Phillips ML. Astrocytomas: the clinical picture. Clin. J. Oncol. Nurs. 2000;4:153–158
  30. Torsteinsdottir S, Masucci MG, Ehlin-Henriksson B, Brautbar C, Ben Bassat H, Klein G, et al. Differentiation-dependent sensitivity of human B-cell-derived lines to major histocompatibility complex-restricted T-cell cytotoxicity. Proc. Natl Acad. Sci. USA. 1986;83:5620–5624
  31. Van Parijs L, Abbas AK. Role of Fas-mediated cell death in the regulation of immune responses. Curr. Opin. Immunol. 1996;8:355–361
  32. Wang ZB, Liu YQ, Cui YF. Pathways to caspase activation. Cell Biol. Int. 2005;29:489–496
  33. Wei J, Barr J, Kong LY, Wang Y, Wu A, Sharma AK, et al. Glioblastoma cancer-initiating cells inhibit T-cell proliferation and effector responses by the signal transducers and activators of transcription 3 pathway. Mol. Cancer Ther. 2010;9:67–78
  34. Zemmour J, Little AM, Schendel DJ, Parham P. The HLA-A, B “negative” mutant cell line C1R expresses a novel HLA-B35 allele, which also has a point mutation in the translation initiation codon. J. Immunol. 1992;148:1941–1948
  35. Zhang QJ, Gavioli R, Klein G, Masucci MG. An HLA-A11-specific motif in nonamer peptides derived from viral and cellular proteins. Proc. Natl Acad. Sci. USA. 1993;90:2217–2221
  36. Zhivotovsky B. Caspases: the enzymes of death. Essays Biochem. 2003;39:25–40
  37. Zhivotovsky B, Orrenius S. Current concepts in cell death. Curr Protoc Cell Biol. 2001;Chapter 18, Unit 18 11

PII: S0165-5728(10)00169-4

doi: 10.1016/j.jneuroim.2010.04.009

Journal of Neuroimmunology
Volume 225, Issue 1 , Pages 34-42 , 25 August 2010

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