Journal of Neuroimmunology
Volume 222, Issue 1 , Pages 87-89 , May 2010

High levels of Anti-GAD65 and Anti-Ro52 autoantibodies in a patient with major depressive disorder showing psychomotor disturbance

  • Kathryn H. Ching

      Affiliations

    • Neurobiology and Pain Therapeutics Section, Laboratory of Sensory Biology, National Institute of Dental and Craniofacial Research, 49 Convent Drive, Bldg 49, 1C20, Bethesda, Maryland, 20892-4410, United States
    • Corresponding Author InformationCorresponding author. NIDCR, NIH, Building 49, Room 1C20, 49 Convent Drive, Bethesda, MD, 20892-4410, United States. Tel.: +1 301 594 0252; fax: +1 301 402 0667.
    • ,
  • Peter D. Burbelo

      Affiliations

    • Neurobiology and Pain Therapeutics Section, Laboratory of Sensory Biology, National Institute of Dental and Craniofacial Research, 49 Convent Drive, Bldg 49, 1C20, Bethesda, Maryland, 20892-4410, United States
    • ,
  • Paul J. Carlson

      Affiliations

    • Section on Neuroimaging in Mood and Anxiety Disorders, National Institute of Mental Health, 15K North Dr., Room 210, Bethesda, MD 20892, United States
    • Current address: University of Utah, School of Medicine, 30 N 1900 E RM 5R210, Salt Lake City, UT 84112, United States.
    • ,
  • Wayne C. Drevets

      Affiliations

    • Section on Neuroimaging in Mood and Anxiety Disorders, National Institute of Mental Health, 15K North Dr., Room 210, Bethesda, MD 20892, United States
    • Current address: University of Oklahoma School of Medicine, Laureate Institute for Brain Research, 6655 So. Yale Ave., Tulsa OK, 73019, United States.
    • ,
  • Michael J. Iadarola

      Affiliations

    • Neurobiology and Pain Therapeutics Section, Laboratory of Sensory Biology, National Institute of Dental and Craniofacial Research, 49 Convent Drive, Bldg 49, 1C20, Bethesda, Maryland, 20892-4410, United States

Received 6 November 2009 ,Revised 17 February 2010 ,Accepted 17 February 2010.

References 

  1. Burbelo PD, Goldman R, Mattson TL. A simplified immunoprecipitation method for quantitatively measuring antibody responses in clinical sera samples by using mammalian-produced Renilla luciferase-antigen fusion proteins. BMC Biotechnol. 2005;5:22
  2. Burbelo PD, Groot S, Dalakas MC, Iadarola MJ. High definition profiling of autoantibodies to glutamic acid decarboxylases GAD65/GAD67 in stiff-person syndrome. Biochem. Biophys. Res. Commun. 2008;366:1–7
  3. Burbelo PD, Hirai H, Leahy H, Lernmark A, Ivarsson SA, Iadarola MJ, et al. A new luminescence assay for autoantibodies to mammalian cell-prepared insulinoma-associated protein 2. Diabetes Care. 2008;31:1824–1826
  4. Burbelo PD, Ching KH, Klimavicz CM, Iadarola MJ. Antibody profiling by Luciferase Immunoprecipitation Systems (LIPS). J. Vis. Exp. 2009;
  5. Burbelo PD, Leahy HP, Issa AT, Groot S, Baraniuk JN, Nikolov NP, et al. Sensitive and robust luminescent profiling of anti-La and other autoantibodies in Sjogren's syndrome. Autoimmunity. 2009;42:515–524
  6. Burbelo PD, Hirai H, Issa AT, Kingman A, Lernmark A, Ivarsson SA, et al. Comparison of radioimmunoprecipitation with luciferase immunoprecipitation for autoantibodies to GAD65 and IA-2{beta}. Diabetes Care. 2010;
  7. Chattopadhyay S, Kriscenski-Perry E, Wenger DA, Pearce DA. An autoantibody to GAD65 in sera of patients with juvenile neuronal ceroid lipofuscinoses. Neurology. 2002;59:1816–1817
  8. Franceschini F, Cavazzana I. Anti-Ro/SSA and La/SSB antibodies. Autoimmunity. 2005;38:55–63
  9. Hadzi-Pavlovic D, Hickie I, Brodaty H, Boyce P, Mitchell P, Wilhelm K, et al. Inter-rater reliability of a refined index of melancholia: the CORE system. J. Affect. Disord. 1993;27:155–162
  10. Iwasaki H, Sato R, Shichiri M, Hirata Y. A patient with type 1 diabetes mellitus and cerebellar ataxia associated with high titer of circulating anti-glutamic acid decarboxylase antibodies. Endocr. J. 2001;48:261–268
  11. Keeble AH, Khan Z, Forster A, James LC. TRIM21 is an IgG receptor that is structurally, thermodynamically, and kinetically conserved. Proc. Natl. Acad. Sci. U. S. A. 2008;105:6045–6050
  12. Kupka RW, Nolen WA, Post RM, McElroy SL, Altshuler LL, Denicoff KD, et al. High rate of autoimmune thyroiditis in bipolar disorder: lack of association with lithium exposure. Biol. Psychiatry. 2002;51:305–311
  13. Levy LM, Dalakas MC, Floeter MK. The stiff-person syndrome: an autoimmune disorder affecting neurotransmission of gamma-aminobutyric acid. Ann. Intern. Med. 1999;131:522–530
  14. Padmos RC, Bekris L, Knijff EM, Tiemeier H, Kupka RW, Cohen D, et al. A high prevalence of organ-specific autoimmunity in patients with bipolar disorder. Biol. Psychiatry. 2004;56:476–482
  15. Parker G, Hadzi-Pavlovic D. Development and structure of the CORE system. In:  Parker G,  Hadzi-Pavlovic D editor. Melancholia: A Disorder of Movement and Mood. New York: Cambridge University Press; 1996;p. 82–129
  16. Solimena M, Folli F, Aparisi R, Pozza G, De Camilli P. Autoantibodies to GABA-ergic neurons and pancreatic beta cells in stiff-man syndrome. N. Engl. J. Med. 1990;322:1555–1560

PII: S0165-5728(10)00064-0

doi: 10.1016/j.jneuroim.2010.02.015

Journal of Neuroimmunology
Volume 222, Issue 1 , Pages 87-89 , May 2010

Article Tools

* Image Usage & Resolution