High levels of Anti-GAD65 and Anti-Ro52 autoantibodies in a patient with major depressive disorder showing psychomotor disturbance

Ching, Kathryn H.; Burbelo, Peter D.; Carlson, Paul J.; Drevets, Wayne C.; Iadarola, Michael J.

doi:10.1016/j.jneuroim.2010.02.015

« Previous Next »Journal of Neuroimmunology
Volume 222, Issue 1 , Pages 87-89, May 2010

High levels of Anti-GAD65 and Anti-Ro52 autoantibodies in a patient with major depressive disorder showing psychomotor disturbance

Kathryn H. Ching
- Neurobiology and Pain Therapeutics Section, Laboratory of Sensory Biology, National Institute of Dental and Craniofacial Research, 49 Convent Drive, Bldg 49, 1C20, Bethesda, Maryland, 20892-4410, United States
- Corresponding author. NIDCR, NIH, Building 49, Room 1C20, 49 Convent Drive, Bethesda, MD, 20892-4410, United States. Tel.: +1 301 594 0252; fax: +1 301 402 0667.
Peter D. Burbelo
- Neurobiology and Pain Therapeutics Section, Laboratory of Sensory Biology, National Institute of Dental and Craniofacial Research, 49 Convent Drive, Bldg 49, 1C20, Bethesda, Maryland, 20892-4410, United States
Paul J. Carlson
- Section on Neuroimaging in Mood and Anxiety Disorders, National Institute of Mental Health, 15K North Dr., Room 210, Bethesda, MD 20892, United States
- Current address: University of Utah, School of Medicine, 30 N 1900 E RM 5R210, Salt Lake City, UT 84112, United States.
Wayne C. Drevets
- Section on Neuroimaging in Mood and Anxiety Disorders, National Institute of Mental Health, 15K North Dr., Room 210, Bethesda, MD 20892, United States
- Current address: University of Oklahoma School of Medicine, Laureate Institute for Brain Research, 6655 So. Yale Ave., Tulsa OK, 73019, United States.
Michael J. Iadarola
- Neurobiology and Pain Therapeutics Section, Laboratory of Sensory Biology, National Institute of Dental and Craniofacial Research, 49 Convent Drive, Bldg 49, 1C20, Bethesda, Maryland, 20892-4410, United States

Received 6 November 2009; received in revised form 17 February 2010; accepted 17 February 2010. published online 15 March 2010.

Abstract

Autoimmune disease and/or autoantibodies have been reported in mood disorder patients. We screened for autoantibodies to glutamic acid decarboxylase (GAD65), thyroid peroxidase (TPO), gastric H+/K+ ATPase (ATP4B), and Ro52 in a psychiatric patient cohort. A 24-year-old woman with major depressive disorder (MDD) with reduced psychomotor activity was identified with unusually high serum GAD65 and Ro52 autoantibody titers. Anti-GAD65 and anti-Ro52 autoantibodies were also elevated in the CSF from this patient. Longitudinal examination revealed a four-fold increase in anti-GAD65 serum antibody titers which correlated with exacerbation of psychomotor symptomatology. These results suggest the possibility that CNS autoimmunity may be responsible for the psychomotor impairment in this MDD patient.

Keywords: GAD65, Ro52, Depression, Autoimmunity, Psychomotor disturbance