Journal of Neuroimmunology
Volume 220, Issue 1 , Pages 99-103, 30 March 2010

Increased urinary free immunoglobulin light chain excretion in patients with multiple sclerosis

  • Ruth Dobson

      Affiliations

    • Neuroimmunology Unit, Queen Mary University of London, Blizard Institute of Cell and Molecular Science, Barts and The London School of Medicine and Dentistry, 4 Newark Street, Whitechapel, London E1 2AT, United Kingdom
    • Corresponding Author InformationCorresponding author. Tel.: +44 207 882 8813; fax: +44 207 377 7033.
    • ,
  • R.F. Miller

      Affiliations

    • Research Department of Infection and Public Health, University College London, London WC1E 6JB, United Kingdom
    • ,
  • H.E. Palmer

      Affiliations

    • Department of Ophthalmology, St Thomas' Hospital, London SW1 7EH, United Kingdom
    • University Hospitals, Birmingham B29 6JD, United Kingdom
    • ,
  • M. Feldmann

      Affiliations

    • Kennedy Institute of Rheumatology, London W6 8LH, United Kingdom
    • ,
  • E.J. Thompson

      Affiliations

    • Institute of Neurology, University College London, Queen Square, London WC1N 3BG, United Kingdom
    • ,
  • A.J. Thompson

      Affiliations

    • Institute of Neurology, University College London, Queen Square, London WC1N 3BG, United Kingdom
    • ,
  • D.H. Miller

      Affiliations

    • Institute of Neurology, University College London, Queen Square, London WC1N 3BG, United Kingdom
    • ,
  • G. Giovannoni

      Affiliations

    • Neuroimmunology Unit, Queen Mary University of London, Blizard Institute of Cell and Molecular Science, Barts and The London School of Medicine and Dentistry, 4 Newark Street, Whitechapel, London E1 2AT, United Kingdom
    • Institute of Neurology, University College London, Queen Square, London WC1N 3BG, United Kingdom

Received 30 October 2009; received in revised form 4 January 2010; accepted 20 January 2010. published online 22 February 2010.

Abstract 

Background

Plasma and B cells are implicated in multiple sclerosis (MS) and produce free light chains (FLC) that are excreted in urine.

Objective

To confirm that demyelinating diseases (DD) cause increased urinary FLCs.

Method

Urinary FLC in 50 patients with DD were compared to 20 patients with posterior uveitis (PU), 19 with AIDS, 34 with rheumatoid arthritis (RA) and 19 normal controls (NC).

Result

Subjects with DD, PU, RA and AIDS have higher urinary FLCs than NC (p<0.01). Urinary FLCs did not correlate with gadolinium-enhancing lesions on MRI.

Conclusions

Urinary FLCs are raised in DD. Further studies are required to see if they correlate with disease activity.

Keywords: Urine, Nitrate, Nitrite, Rheumatoid arthritis, HIV-1, Posterior uveitis

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PII: S0165-5728(10)00017-2

doi:10.1016/j.jneuroim.2010.01.012

Journal of Neuroimmunology
Volume 220, Issue 1 , Pages 99-103, 30 March 2010

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