Journal of Neuroimmunology
Volume 220, Issue 1 , Pages 64-68 , 30 March 2010

Role of endothelin receptors in the control of central nervous system parasitism in Trypanosoma cruzi infection in rats

  • Milene A. Rachid

      Affiliations

    • Departamento de Patologia Geral, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais (UFMG), 31270901, Belo Horizonte, MG, Brazil
    • Corresponding Author InformationCorresponding author. Tel.: +55 31 3409 2649; fax: +55 31 3409 2614.
    • ,
  • Antônio L. Teixeira

      Affiliations

    • Departamento de Bioquímica, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais (UFMG), 31270901, Belo Horizonte, MG, Brazil
    • ,
  • Lucíola S. Barcelos

      Affiliations

    • Departamento de Bioquímica, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais (UFMG), 31270901, Belo Horizonte, MG, Brazil
    • ,
  • Conceição R.S. Machado

      Affiliations

    • Departamento de Patologia Geral, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais (UFMG), 31270901, Belo Horizonte, MG, Brazil
    • ,
  • Egler Chiari

      Affiliations

    • Departamento de Parasitologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais (UFMG), 31270901, Belo Horizonte, MG, Brazil
    • ,
  • Herbert B. Tanowitz

      Affiliations

    • Department of Pathology, Albert Einstein College of Medicine, Bronx, NY, USA
    • ,
  • Elizabeth R.S. Camargos

      Affiliations

    • Departamento de Patologia Geral, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais (UFMG), 31270901, Belo Horizonte, MG, Brazil
    • ,
  • Mauro M. Teixeira

      Affiliations

    • Departamento de Bioquímica, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais (UFMG), 31270901, Belo Horizonte, MG, Brazil

Received 24 August 2009 ,Revised 2 December 2009 ,Accepted 12 January 2010.

References 

  1. Aliberti JC, Machado FS, Souto JT, Campanelli AP, Teixeira MM, Gazzinelli RT, et al. Beta-Chemokines enhance parasite uptake and promote nitric oxide-dependent microbiostatic activity in murine inflammatory macrophages infected with Trypanosoma cruzi. Infect. Immun. 1999;67:4819–4826
  2. Camargos ERS, Franco DJ, Garcia CMMG, Dutra AP, Teixeira AL, Chiari E, et al. Infection with different Trypanosoma cruzi populations in rats: myocarditis, cardiac sympathetic denervation, and involvement of digestive organs. Am. J. Trop. Med. Hyg. 2000;62:604–612
  3. Camargos ERS, Machado CRS, Teixeira AL, Rocha LLV, Ferreira AJ, Almeida AP, et al. Role of endothelins during experimental Trypanosoma cruzi infection in rats. Clin. Sci., Suppl. 2002;48:64S–67S
  4. Camargos ERS, Rocha LLV, Rachid MA, Almeida AP, Ferreira AJ, Teixeira-Jr AL, et al. Protective role of ETA endothelin receptors during the acute phase of Trypanosoma cruzi infection in rats. Microbes Infect. 2004;6:650–656
  5. Coelho PS, Klein A, Talvani A, Coutinho SF, Takeuchi O, Akira S, et al. Glycosylphosphatidylinositol- anchored mucin-like glycoproteins isolated from Trypanosoma cruzi trypomastigotes induce in vivo leukocyte recruitment dependent on MCP-1 production by IFN-gamma-primed-macrophages. J. Leukoc. Biol. 2002;71:837–844
  6. Da Mata JR, Camargos ERS, Chiari E, Machado CRS. Trypanosoma cruzi infection and the rat central nervous system: proliferation of parasites in astrocytes and the brain reaction to parasitism. Brain Res. Bull. 2000;53:153–162
  7. Elshourbagy NA, Korman DR, Wu HL, Sylvester DR, Lee JA, Nuthalaganti P. Molecular characterization and regulation of the human endothelin receptors. J. Biol. Chem. 1993;268:3873–3879
  8. Ferreira MS, Nishioka SA, Rocha A, Silva AM, Ferreira RG, Olivier W, et al. Acute fatal Trypanosoma cruzi meningoencephalitis in a human immunodeficiency virus-positive hemophilic patient. Am. J. Trop. Med. Hyg. 1991;45:723–727
  9. Filipovich T, Fleisher-Berkovich S. Regulation of glial inflammatory mediators synthesis: possible role of endothelins. Peptides. 2008;29:2250–2256
  10. Hama H, Kasuya Y, Sakurai T, Yamada G, Suzuki N, Masaki T. Role of endothelin-1 in astrocyte responses after acute brain damage. J. Neurosci. Res. 1997;47:590–602
  11. Ishikawa N, Takemura M, Koyama Y, Shigenaga Y, Okada T, Baba A. Endothelins promote the activation of astrocytes in rat neostriatum through ETB receptors. Eur. J. Neurosci. 1997;9:895–901
  12. Koyama Y, Baba A, Matsuda T. Production of monocyte chemoattractant protein-1 and cytokine-induced neutrophil chemoattractant-1 in rat brain is stimulated by intracerebroventricular administration of an endothelin ETB receptor agonist. Neuroreport. 2007;18:1275–1279
  13. Leiguarda R, Roncoroni A, Taratuto AL, Berthier M, Nogues M, Freilij H. Acute CNS infection by Trypanosoma cruzi (Chagas´disease) in immunossupressed patients. Neurology. 1990;40:850–851
  14. Machado CR, Camargos ER. Endothelins role in the control of the acute phase of Trypanosoma cruzi infection. Mini Rev. Med. Chem. 2008;8:820–827
  15. Machado FS, Koyama NS, Carregaro V, Ferreira BR, Milanezi CM, Teixeira MM, et al. CCR5 plays a critical role in the development of myocarditis and host protection in mice infected with Trypanosoma cruzi. J. Infect. Dis. 2005;191:627–636
  16. Machado FS, Desruisseaux MS, Nagajyothi KRP, Hetherington HP, Wittner M, Weiss LM, et al. Endothelin in a murine model of cerebral malaria. Exp. Biol. Med. (Maywood). 2006;231:1176–1181
  17. Matsushima H, Yamada N, Matsue H, Shimada S. The effects of endothelin-1 on degranulation, cytokine, and growth factor production by skin-derived mast cells. Eur. J. Immunol. 2004;34:1910–1919
  18. Pittella JEH. Central nervous system involvement in Chagas' disease. An updating. Rev. Inst. Med. Trop. São Paulo. 1993;35:111–116
  19. Pittman QJ. Endothelin — an emerging role in proinflammatory pathways in brain. Am. J. Physiol. Regulatory Integrative Comp. Physiol. 2006;290:162–163
  20. Rachid MA, Camargos ER, Barcellos L, Marques CA, Chiari E, Huang H, et al. Blockade of endothelin ET(A)/ET(B) receptors favors a role for endothelin during acute Trypanosoma cruzi infection in rats. Microbes Infect. 2006;8:2113–2119
  21. Rocha A, Menezes AC, Da Silva AM. Pathology of patients with Chagas disease and acquired immunodeficiency syndrome. Am. J. Trop. Med. 1994;50:261–268
  22. Roffê E, Souza ALS, Machado PP, Barcelos LS, Romanha AJ, Mariano FS, et al. Endothelin-1 receptors play a minor role in the protection against acute Trypanosoma cruzi infection in mice. Braz. J. Biol. Res. 2007;40:391–399
  23. Roux S, Breu V, Ertel SI, Clozel M. Endothelin antagonism with bosentan: a review of potential applications. J. Mol. Med. 1999;77:364–376
  24. Shah R. Endothelins in health and disease. Eur. J. Intern. Med. 2007;18:272–282
  25. Silva JS, Vespa GNR, Cardoso MAG, Aliberti JCS, Cunha FQ. Tumor necrosis factor alpha mediates resistance to Trypanosoma cruzi infection in mice by inducing nitric oxide production in infected gamma interferon-activated macrophages. Infect. Immun. 1995;63:4862–4867
  26. Silva AA, Roffe E, Marino AP, dos Santos PV, Quirico-Santos T, Paiva CN, et al. Chagas' disease encephalitis: intense CD8+ lymphocytic infiltrate is restrict to the acute phase, but is not related to the presence of Trypanosoma cruzi antigens. Clin. Immunol. 1999;92:56–66
  27. Silva AA, Roffê E, Santiago H, Marino AP, Kroll-Palhares K, Teixeira MM, et al. Trypanosoma cruzi-triggered meningoencephalitis is a CCR1/CCR5-independent inflammatory process. J. Neuroimmunol. 2007;184:156–163
  28. Souza-Rodrigues RD, Costa AMR, Lima RR, Dos Santos CD, Picanço-Diniz CW, Gomes-Leal W. Inflammatory response and white matter damage after microinjections of endothelin-1 into the rat striatum. Brain Res. 2008;20:78–88
  29. Vespa GN, Cunha FQ, Silva JS. Nitric oxide is involved in control of Trypanosoma cruzi-induced parasitemia and directly kills the parasite in vitro. Infect. Immun. 1994;62:5177–5182

PII: S0165-5728(10)00013-5

doi: 10.1016/j.jneuroim.2010.01.008

Journal of Neuroimmunology
Volume 220, Issue 1 , Pages 64-68 , 30 March 2010

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