Journal of Neuroimmunology
Volume 221, Issue 1 , Pages 112-114 , 15 April 2010

No evidence of association of the rare nsSNP rs35667974 in IFIH1 with multiple sclerosis

  • Laura Bergamaschi

      Affiliations

    • Department of Medical Sciences and Interdisciplinary Research Center of Autoimmune Diseases (IRCAD), University of Eastern Piedmont, Novara, Italy
    • Corresponding Author InformationCorresponding author. Department of Medical Sciences, Eastern Piedmont University, Via Solaroli 17, 28100 Novara, Italy. Tel.: +39 0321 660606; fax: +39 0321 620421.
    • ,
  • Maria Ban

      Affiliations

    • University of Cambridge, Department of Clinical Neuroscience, Addenbrooke's Hospital, Hills Road, Cambridge, CB2 2QQ, UK
    • ,
  • Maurizio A. Leone

      Affiliations

    • Department of Neurology, Ospedale Maggiore della Carità, and IRCAD, Novara, Italy
    • ,
  • Stephen J. Sawcer

      Affiliations

    • University of Cambridge, Department of Clinical Neuroscience, Addenbrooke's Hospital, Hills Road, Cambridge, CB2 2QQ, UK
    • ,
  • Sandra D'Alfonso

      Affiliations

    • Department of Medical Sciences and Interdisciplinary Research Center of Autoimmune Diseases (IRCAD), University of Eastern Piedmont, Novara, Italy

Received 12 November 2009 ,Revised 11 January 2010 ,Accepted 11 January 2010.

References 

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  4. International Multiple Sclerosis Genetics Consortium (IMSGC). The expanding overlap between multiple sclerosis and type 1 diabetes. Genes Immun. 2009;10:11–14
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  6. Liu S, Wang H, Jin Y, Podolsky R, Reddy MV, Pedersen J, et al. IFIH1 polymorphisms are significantly associated with type 1 diabetes and IFIH1 gene expression in peripheral blood mononuclear cells. Hum. Mol. Genet. 2009;18:358–365
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  9. Nejentsev S, Walker N, Riches D, Egholm M, Todd JA. Rare variants of IFIH1, a gene implicated in antiviral responses, protect against type 1 diabetes. Science. 2009;324:387–389
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  11. Serafini B, Rosicarelli B, Franciotta D, Magliozzi R, Reynolds R, Cinque P, et al. Dysregulated Epstein–Barr virus infection in the multiple sclerosis brain. J. Exp. Med. 2007;204:2899–2912
  12. Shigemoto T, Kageyama M, Hirai R, Zheng J, Yoneyama M, Fujita T. Identification of loss of function mutations in human genes encoding RIG-I and MDA5: implications for resistance to type I diabetes. J. Biol. Chem. 2009;284:13348–13354
  13. Smyth DJ, Cooper JD, Bailey R, Field S, Burren O, Smink LJ, et al. A genome-wide association study of nonsynonymous SNPs identifies a type 1 diabetes locus in the interferon-induced helicase (IFIH1) region. Nat. Genet. 2006;38:617–619
  14. Sriram S, Stratton CW, Yao S, Tharp A, Ding L, Bannan JD, et al. Chlamydia pneumoniae infection of the central nervous system in multiple sclerosis. Ann. Neurol. 1999;46:6–14
  15. Zhernakova A, van Diemen CC, Wijmenga C. Detecting shared pathogenesis from the shared genetics of immune-related diseases. Nat. Rev. Genet. 2009;10:43–55

PII: S0165-5728(10)00010-X

doi: 10.1016/j.jneuroim.2010.01.005

Journal of Neuroimmunology
Volume 221, Issue 1 , Pages 112-114 , 15 April 2010

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