Journal of Neuroimmunology
Volume 221, Issue 1 , Pages 115-120 , 15 April 2010

IFN-β reverses the lipopolysaccharide-induced proteome modifications in treated astrocytes

  • Daniele Vergara

      Affiliations

    • Laboratory of General Physiology, Department of Biological and Environmental Sciences and Technologies, University of Salento, via Monteroni 73100, Lecce, Italy
    • ,
  • Roberta Martignago

      Affiliations

    • Laboratory of Anatomy, Department of Biological and Environmental Sciences and Technologies, University of Salento, via Monteroni 73100, Lecce, Italy
    • ,
  • Stefania Bonsegna

      Affiliations

    • Institute of Sciences of Food Production CNR-ISPA, Unit of Lecce, Italy
    • ,
  • Francesco De Nuccio

      Affiliations

    • Laboratory of Anatomy, Department of Biological and Environmental Sciences and Technologies, University of Salento, via Monteroni 73100, Lecce, Italy
    • ,
  • Angelo Santino

      Affiliations

    • Institute of Sciences of Food Production CNR-ISPA, Unit of Lecce, Italy
    • ,
  • Giuseppe Nicolardi

      Affiliations

    • Laboratory of Anatomy, Department of Biological and Environmental Sciences and Technologies, University of Salento, via Monteroni 73100, Lecce, Italy
    • ,
  • Michele Maffia

      Affiliations

    • Laboratory of General Physiology, Department of Biological and Environmental Sciences and Technologies, University of Salento, via Monteroni 73100, Lecce, Italy
    • Laboratory of Clinical Proteomic, “Vito Fazzi” Hospital, ASL-Lecce, Italy
    • Corresponding Author InformationCorresponding author. Laboratory of General Physiology, Department of Biological and Environmental Sciences and Technologies, University of Salento, via Monteroni 73100, Lecce, Italy. Fax: +39 0832 324200.

Received 15 November 2009 ,Revised 5 January 2010 ,Accepted 5 January 2010.

References 

  1. Barca O, Ferre´ S, Seoane M, Prieto JM, Lema M, Señarís R, et al. Interferon beta promotes survival in primary astrocytes through phosphatidylinositol 3-kinase. J. Neuroimmunol. 2003;139:155–159
  2. Barca O, Seoane M, Ferré S, Prieto JM. Mechanisms of interferon-β-induced survival in fetal and neonatal primary astrocytes. Neuroimmunomodulation. 2007;14:39–45
  3. Barca O, Costoya JA, Señarís RM, Arce VM. Interferon-β protects astrocytes against tumour necrosis factor-induced apoptosis via activation of p38 mitogen-activated protein kinase. Exp. Cell Res. 2008;314:2231–2237
  4. Barna BP, Chou SM, Jacobs B, Yen-Lieberman B, Ransohoff RM. Interferon-beta impairs induction of HLA-DR antigen expression in cultured adult human astrocytes. J. Neuroimmunol. 1989;23:45–53
  5. Chakravortty D, Nanda Kumar KS. Bacterial lipopolysaccharide induces cytoskeletal rearrangement in small intestinal lamina propria fibroblasts: actin assembly is essential for lipopolysaccharide signalling. Biochim. Biophys. Acta. 2000;1500:125–136
  6. De Masi R, Vergara D, Pasca S, Acierno R, Greco M, Spagnolo L, et al. PBMCs protein expression profile in relapsing IFN-treated multiple sclerosis: a pilot study on relation to clinical findings and brain atrophy. J. Neuroimmunol. 2009;210:80–86
  7. Dong Y, Benveniste EN. Immune function of astrocytes. Glia. 2001;36:180–190
  8. Guo B, Chang EY, Cheng G. The type I IFN induction pathway constrains Th17-mediated autoimmune inflammation in mice. J. Clin. Invest. 2008;118:1680–1690
  9. Guthikonda P, Baker J, Mattson DH. Interferon-beta-1-b (IFN-B) decreases induced nitric oxide (NO) production by a human astrocytoma cell line. J. Neuroimmunol. 1998;82:133–139(7)
  10. Hamamcioglu K, Reder AT. Interferon-beta regulates cytokines and BDNF: greater effect in relapsing than in progressive multiple sclerosis. Mult. Scler. 2007;13:459–470
  11. Kappos L, Traboulsee A, Constantinescu C, Erälinna JP, Forrestal F, Jongen P, et al. Long-term subcutaneous interferon beta-1a therapy in patients with relapsing-remitting MS. Neurology. 2006;67:944–953
  12. Malik O, Compston DA, Scolding NJ. Interferon-beta inhibits mitogen induced astrocyte proliferation in vitro. J. Neuroimmunol. 1998;86:155–162
  13. McCarthy KD, de Vellis J. Preparation of separate astroglial and oligodendroglial cell cultures from rat cerebral tissue. J. Cell Biol. 1980;85:890–902
  14. McNaught KSP, Jenner P. Extracellular accumulation of nitric oxide, hydrogen peroxide, and glutamate in astrocytic cultures following glutathione depletion, complex I inhibition, and/or lipopolysaccharide-induced activation. Biochem. Pharmacol. 2000;60:979–988
  15. Miljkovic D, Momcilovic M, Stojanovic I, Stosic-Grujicic S, Ramic Z, Mostarica-Stojkovic M. Astrocytes stimulate interleukin-17 and interferon-γ production in vitro. J. Neurosci. Res. 2007;85:3598–3606
  16. Nair A, Frederick TJ, Miller SD. Astrocytes in multiple sclerosis: a product of their environment. Cell. Mol. Life Sci. 2008;65:2702–2720
  17. Satoh J, Kuroda Y. Differing effects of IFN beta vs. IFN gamma in MS: gene expression in cultured astrocytes. Neurology. 2001;57:681–685
  18. Satoh J, Paty DW, Kim SU. Counteracting effect of IFN-beta on IFN-gamma-induced proliferation of human astrocytes in culture. Mult. Scler. 1996;1:279–287
  19. Stewart VC, Giovannoni G, Land JM, McDonald WI, Clark JB, Heales SJ. Pretreatment of astrocytes with interferon-alpha/beta impairs interferon-gamma induction of nitric oxide synthase. J. Neurochem. 1997;68:2547–2551
  20. Stewart VC, Land JM, Clark JB, Heales SJ. Pretreatment of astrocytes with interferon-alpha/beta prevents neuronal mitochondrial respiratory chain damage. J. Neurochem. 1998;70:432–434
  21. Tedeschi B, Barrett JN, Keane RW. Astrocytes produce interferon that enhances the expression of H-2 antigens on a subpopulation of brain cells. J. Cell Biol. 1986;102:2244–2253
  22. Trojano M, Pellegrini F, Fuiani A, Paolicelli D, Zipoli V, Zimatore GB, et al. New natural history of interferon-beta-treated relapsing multiple sclerosis. Ann. Neurol. 2007;61:300–306
  23. Vergara D, Chiriacò F, Acierno R, Maffia M. Proteomic map of peripheral blood mononuclear cells. Proteomics. 2008;8:2045–2051
  24. Vergara D, Martignago R, Leporatti S, Bonsegna S, Maruccio G, De Nuccio F, et al. Biomechanical and proteomic analysis of INF-beta-treated astrocytes. Nanotechnology. 2009;20:455106
  25. Zanon RG, Oliveira AL. MHC I upregulation influences astroglial reaction and synaptic plasticity in the spinal cord after sciatic nerve transaction. Exp. Neurol. 2006;200:521–531

PII: S0165-5728(10)00007-X

doi: 10.1016/j.jneuroim.2010.01.002

Journal of Neuroimmunology
Volume 221, Issue 1 , Pages 115-120 , 15 April 2010

Article Tools

* Image Usage & Resolution