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Journal of Neuroimmunology
Volume 221, Issue 1
, Pages 7-14
, 15 April 2010
Role of the innate immune system in the pathogenesis of multiple sclerosis
References
- . Immunoregulatory factors in multiple sclerosis patients during and after pregnancy: relevance of natural killer cells. Clin. Exp. Immunol. 2008;151:235–243
- . Pivotal advance: HMGB1 expression in active lesions of human and experimental multiple sclerosis. J. Leukoc. Biol. 2008;84:1248–1255
- . FcgammaRIII discriminates between 2 subsets of Vgamma9Vdelta2 effector cells with different responses and activation pathways. Blood. 2004;104:1801–1807
- . Th2 bias of CD4+ NKT cells derived from multiple sclerosis in remission. Int. Immunol. 2003;15:279–288
- . Toll-like receptors in defense and damage of the central nervous system. J. Neuroimmune Pharmacol. 2007;2:297–312
- . CNS myeloid DCs presenting endogenous myelin peptides ‘preferentially’ polarize CD4+ T(H)-17 cells in relapsing EAE. Nat. Immunol. 2007;8:172–180
- . Cytokines in the central nervous system of mice during chronic relapsing experimental allergic encephalomyelitis. Cell Immunol. 1991;134:505–510
- . Phagocytic activity of macrophages and microglial cells during the course of acute and chronic relapsing experimental autoimmune encephalomyelitis. J. Neurosci. Res. 1994;38:365–375
- . Bone marrow-derived mast cells accumulate in the central nervous system during inflammation but are dispensable for experimental autoimmune encephalomyelitis pathogenesis. J. Immunol. 2009;182:5507–5514
- . Cytokines: influence on glial cell gene expression and function. Chem. Immunol. 1997;69:31–75
- . Induction and effector functions of T(H)17 cells. Nature. 2008;453:1051–1057
- . Loss of T-bet, but not STAT1, prevents the development of experimental autoimmune encephalomyelitis. J. Exp. Med. 2004;200:79–87
- . Regulatory CD56(bright) natural killer cells mediate immunomodulatory effects of IL-2Ralpha-targeted therapy (daclizumab) in multiple sclerosis. Proc. Natl. Acad. Sci. U. S. A. 2006;103:5941–5946
- . Broad expression of Toll-like receptors in the human central nervous system. J. Neuropathol. Exp. Neurol. 2002;61:1013–1021
- . Correlation of specialized CD16(+) gammadelta T cells with disease course and severity in multiple sclerosis. J. Neuroimmunol. 2008;194:147–152
- . The multitasking mast cell: positive and negative roles in the progression of autoimmunity. J. Immunol. 2007;179:2673–2679
- . The biology of human natural killer-cell subsets. Trends Immunol. 2001;22:633–640
- . Human natural killer cells: a unique innate immunoregulatory role for the CD56(bright) subset. Blood. 2001;97:3146–3151
- . Innate immune-mediated neuronal injury consequent to loss of astrocytes. J. Neuropathol. Exp. Neurol. 2008;67:590–599
- . Cytometric profiling in multiple sclerosis uncovers patient population structure and a reduction of CD8low cells. Brain. 2008;131:1701–1711
- . Natural history of multiple sclerosis in a population-based cohort. Eur. J. Neurol. 2008;15:916–921
- . Multidirectional interactions are bridging human NK cells with plasmacytoid and monocyte-derived dendritic cells during innate immune responses. Blood. 2006;108:3851–3858
- . The natural killer cell-mediated killing of autologous dendritic cells is confined to a cell subset expressing CD94/NKG2A, but lacking inhibitory killer Ig-like receptors. Eur. J. Immunol. 2003;33:1657–1666
- . Presentation of the self antigen myelin basic protein by dendritic cells leads to experimental autoimmune encephalomyelitis. J. Immunol. 1999;163:32–39
- . New insights into cell responses involved in experimental autoimmune encephalomyelitis and multiple sclerosis. Immunol. Lett. 2005;96:11–26
- . Human dendritic cells activate resting natural killer (NK) cells and are recognized via the NKp30 receptor by activated NK cells. J. Exp. Med. 2002;195:343–351
- . Dendritic cells directly trigger NK cell functions: cross-talk relevant in innate anti-tumor immune responses in vivo. Nat. Med. 1999;5:405–411
- . gamma delta T-cell-human glial cell interactions. II. Relationship between heat shock protein expression and susceptibility to cytolysis. J. Neuroimmunol. 1997;74:143–148
- . gamma delta T-cell-human glial cell interactions. I. In vitro induction of gammadelta T-cell expansion by human glial cells. J. Neuroimmunol. 1997;74:135–142
- . Peripheral blood gamma-delta T cells lyse fresh human brain-derived oligodendrocytes. Ann. Neurol. 1991;30:794–800
- . Activation of invariant NKT cells by alphaGalCer administration protects mice from MOG35-55-induced EAE: critical roles for administration route and IFN-gamma. Eur. J. Immunol. 2003;33:1830–1838
- . EAE tolerance induction with Hsp70-peptide complexes depends on H60 and NKG2D activity. J. Immunol. 2007;179:4503–4512
- . Reciprocal activating interaction between natural killer cells and dendritic cells. J. Exp. Med. 2002;195:327–333
- . Generation of human CD8 T regulatory cells by CD40 ligand-activated plasmacytoid dendritic cells. J. Exp. Med. 2002;195:695–704
- . Elevated activity and microglial expression of myeloperoxidase in demyelinated cerebral cortex in multiple sclerosis. Brain Pathol. 2008;18:86–95
- . Mast cells are required for optimal autoreactive T cell responses in a murine model of multiple sclerosis. Eur. J. Immunol. 2005;35:3478–3486
- . Neuroprotection by encephalomyelitis: rescue of mechanically injured neurons and neurotrophin production by CNS-infiltrating T and natural killer cells. J. Neurosci. 2000;20:5283–5291
- . [gamma][delta] cells: a right time and a right place for a conserved third way of protection. Annu. Rev. Immunol. 2000;18:975–1026
- . Prevention of experimental autoimmune encephalomyelitis by transfer of embryonic stem cell-derived dendritic cells expressing myelin oligodendrocyte glycoprotein peptide along with TRAIL or programmed death-1 ligand. J. Immunol. 2005;174:1888–1897
- . The neuronal chemokine CX3CL1/fractalkine selectively recruits NK cells that modify experimental autoimmune encephalomyelitis within the central nervous system. Faseb. J. 2006;20:896–905
- . Multiple sclerosis is associated with high levels of circulating dendritic cells secreting pro-inflammatory cytokines. J. Neuroimmunol. 1999;99:82–90
- . Osteopontin-induced relapse and progression of autoimmune brain disease through enhanced survival of activated T cells. Nat. Immunol. 2007;8:74–83
- . Differential expression of NK T cell V alpha 24
J alpha Q invariant TCR chain in the lesions of multiple sclerosis and chronic inflammatory demyelinating polyneuropathy. J. Immunol. 2000;164:4375–4381 - . Th1 polarization of CD4+ T cells by Toll-like receptor 3-activated human microglia. J. Neuropathol. Exp. Neurol. 2007;66:848–859
- . The role of mast cells in demyelination. 1. Myelin proteins are degraded by mast cell proteases and myelin basic protein and P2 can stimulate mast cell degranulation. Brain Res. 1988;444:195–198
- . Innate immunity in multiple sclerosis: myeloid dendritic cells in secondary progressive multiple sclerosis are activated and drive a proinflammatory immune response. J. Immunol. 2006;177:4196–4202
- . Clinical relapses of multiple sclerosis are associated with ‘novel’ valleys in natural killer cell functional activity. J. Neuroimmunol. 2003;145:103–114
- . A role for natural killer cells in the immunopathogenesis of multiple sclerosis. J. Neuroimmunol. 1998;86:123–133
- . Temporal development of autoreactive Th1 responses and endogenous presentation of self myelin epitopes by central nervous system-resident APCs in Theiler's virus-infected mice. J. Immunol. 2000;165:5304–5314
- . Production and functions of IL-17 in microglia. J. Neuroimmunol. 2008;194:54–61
- . Luteolin inhibits myelin basic protein-induced human mast cell activation and mast cell-dependent stimulation of Jurkat T cells. Br. J. Pharmacol. 2008;155:1076–1084
- . Mechanisms of acquired thymic tolerance in experimental autoimmune encephalomyelitis: thymic dendritic-enriched cells induce specific peripheral T cell unresponsiveness in vivo. J. Exp. Med. 1995;182:357–366
- . Aggravation of murine experimental allergic encephalomyelitis by administration of T-cell receptor gammadelta-specific antibody. J. Neuroimmunol. 1997;73:169–174
- . Th17 cells: effector T cells with inflammatory properties. Semin. Immunol. 2007;19:362–371
- . Cortical demyelination and diffuse white matter injury in multiple sclerosis. Brain. 2005;128:2705–2712
- . Toll-like receptors and inflammation in the CNS. Curr. Drug Targets Inflamm. Allergy. 2002;1:181–191
- . Dendritic cells transduced with SOCS-3 exhibit a tolerogenic/DC2 phenotype that directs type 2 Th cell differentiation in vitro and in vivo. J. Immunol. 2006;177:1679–1688
- . Dendritic cells: immune regulators in health and disease. Physiol. Rev. 2002;82:97–130
- . Gene-microarray analysis of multiple sclerosis lesions yields new targets validated in autoimmune encephalomyelitis. Nat. Med. 2002;8:500–508
- . A pilot, open label, clinical trial using hydroxyzine in multiple sclerosis. Int. J. Immunopathol. Pharmacol. 2005;18:771–778
- . Dendritic cells prime natural killer cells by trans-presenting interleukin 15. Immunity. 2007;26:503–517
- . Human NK cells kill resting but not activated microglia via NKG2D- and NKp46-mediated recognition. J. Immunol. 2008;181:6170–6177
- . Characterization of human blood dendritic cell subsets. Blood. 2002;100:4512–4520
- . Mast cells process bacterial Ags through a phagocytic route for class I MHC presentation to T cells. J. Immunol. 1996;156:1490–1496
- . Cutting edge: V alpha 14-J alpha 281 NKT cells naturally regulate experimental autoimmune encephalomyelitis in nonobese diabetic mice. J. Immunol. 2002;168:6007–6011
- . Unexpected regulatory roles of TLR4 and TLR9 in experimental autoimmune encephalomyelitis. Eur. J. Immunol. 2008;38:565–575
- . Regulation of autoimmune encephalomyelitis by toll-like receptors. Autoimmun. Rev. 2009;8:506–509
- . Role of natural killer cells and TCR gamma delta T cells in acute autoimmune encephalomyelitis. Eur. J. Immunol. 1998;28:1681–1688
- . Epitope spreading initiates in the CNS in two mouse models of multiple sclerosis. Nat. Med. 2005;11:335–339
- . Mast cell activation by myelin through scavenger receptor. J. Neuroimmunol. 2008;200:27–40
- . Repetitive injections of dendritic cells matured with tumor necrosis factor alpha induce antigen-specific protection of mice from autoimmunity. J. Exp. Med. 2002;195:15–21
- . Antigen presentation in the CNS by myeloid dendritic cells drives progression of relapsing experimental autoimmune encephalomyelitis. Ann. N. Y. Acad. Sci. 2007;1103:179–191
- . CD4+, CD8+, and CD4- CD8- T cells in CSF and blood of patients with multiple sclerosis and tension headache. Scand. J. Immunol. 1990;31:493–501
- . Th1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease. Nature. 2002;415:536–541
- . Role of natural killer cells in the pathogenesis and progression of multiple sclerosis. Pharmacol. Res. 2008;57:1–5
- . NK cells at the interface between innate and adaptive immunity. Cell Death Differ. 2008;15:226–233
- . Effector and regulatory events during natural killer-dendritic cell interactions. Immunol. Rev. 2006;214:219–228
- . Increased osteopontin expression in dendritic cells amplifies IL-17 production by CD4+ T cells in experimental autoimmune encephalomyelitis and in multiple sclerosis. J. Immunol. 2008;181:7480–7488
- . Microglial clearance function in health and disease. Neuroscience. 2009;158:1030–1038
- . Protective effects of microglia in multiple sclerosis. Exp. Neurol. 2009;
- . Gammadelta T cells enhance the expression of experimental autoimmune encephalomyelitis by promoting antigen presentation and IL-12 production. J. Immunol. 2004;173:682–694
- . Gamma delta T cell receptor variable region usage during the development of experimental allergic encephalomyelitis. J. Neuroimmunol. 1995;62:1–7
- . Mast cells in plaques of multiple sclerosis. Acta Neurol. Scand. 1974;50:611–618
- . Costimulation-dependent modulation of experimental autoimmune encephalomyelitis by ligand stimulation of V alpha 14 NK T cells. J. Immunol. 2001;166:662–668
- . Differentiation of human NK cells into NK1 and NK2 subsets. J. Immunol. 1998;161:5821–5824
- . Identification of soluble TREM-2 in the cerebrospinal fluid and its association with multiple sclerosis and CNS inflammation. Brain. 2008;131:3081–3091
- . Blockade of TREM-2 exacerbates experimental autoimmune encephalomyelitis. Eur. J. Immunol. 2007;37:1290–1301
- . Contact-dependent stimulation and inhibition of dendritic cells by natural killer cells. J. Exp. Med. 2002;195:335–341
- . Gamma delta T cells regulate the extent and duration of inflammation in the central nervous system by a Fas ligand-dependent mechanism. J. Immunol. 2005;174:4678–4687
- . Gamma delta T cell regulation of IFN-gamma production by central nervous system-infiltrating encephalitogenic T cells: correlation with recovery from experimental autoimmune encephalomyelitis. J. Immunol. 2004;173:1587–1595
- . Innate immunity mediated by TLR9 modulates pathogenicity in an animal model of multiple sclerosis. J. Clin. Invest. 2006;116:456–464
- . Brain microglia and blood-derived macrophages: molecular profiles and functional roles in multiple sclerosis and animal models of autoimmune demyelinating disease. Brain Res. Brain Res. Rev. 2004;46:261–281
- . A pathogenic role for gamma delta T cells in relapsing-remitting experimental allergic encephalomyelitis in the SJL mouse. J. Immunol. 1996;157:941–949
- . The effect of gammadelta T cell depletion on cytokine gene expression in experimental allergic encephalomyelitis. J. Immunol. 1998;160:5955–5962
- . Persistent activation of microglia is associated with neuronal dysfunction of callosal projecting pathways and multiple sclerosis-like lesions in relapsing–remitting experimental autoimmune encephalomyelitis. Brain. 2007;130:2816–2829
- . Longitudinal analysis of immune cell phenotypes in early stage multiple sclerosis: distinctive patterns characterize MRI-active patients. Brain. 2006;129:1993–2007
- . Regulatory CD56bright natural killer cells expanded during cyclophosphamide therapy in multiple sclerosis. Mult Scler Sept 2007– Supplement 2, S35. 2007;
- . Cutting edge: both activating and inhibitory Fc receptors expressed on mast cells regulate experimental allergic encephalomyelitis disease severity. J. Immunol. 2003;170:1630–1634
- . Activation of human NK cells by plasmacytoid dendritic cells and its modulation by CD4+ T helper cells and CD4+ CD25hi T regulatory cells. Eur. J. Immunol. 2005;35:2452–2458
- . Elevated mast cell tryptase in cerebrospinal fluid of multiple sclerosis patients. Ann. Neurol. 1995;37:63–66
- . Prognostic factors in a multiple sclerosis incidence cohort with twenty-five years of follow-up. Brain. 1993;116(Pt 1):117–134
- . NKG2D-mediated cytotoxicity toward oligodendrocytes suggests a mechanism for tissue injury in multiple sclerosis. J. Neurosci. 2007;27:1220–1228
- . Expansion of CD56Bright natural killer cells in the peripheral blood of multiple sclerosis patients treated with interferon-beta. Neurol. Sci. 2007;28:121–126
- . Mast cells are essential for early onset and severe disease in a murine model of multiple sclerosis. J. Exp. Med. 2000;191:813–822
- . Colocalization of lymphocytes bearing gamma delta T-cell receptor and heat shock protein hsp65+ oligodendrocytes in multiple sclerosis. Proc. Natl. Acad. Sci. U. S. A. 1991;88:6452–6456
- . Intracerebral recruitment and maturation of dendritic cells in the onset and progression of experimental autoimmune encephalomyelitis. Am. J. Pathol. 2000;157:1991–2002
- . Expression of TWEAK and its receptor Fn14 in the multiple sclerosis brain: implications for inflammatory tissue injury. J. Neuropathol. Exp. Neurol. 2008;67:1137–1148
- . Clonal expansions of activated gamma/delta T cells in recent-onset multiple sclerosis. Proc. Natl. Acad. Sci. U. S. A. 1993;90:923–927
- . Immunity or tolerance? That is the question for dendritic cells. Nat. Immunol. 2001;2:988–989
- . The nature of the principal type 1 interferon-producing cells in human blood. Science. 1999;284:1835–1837
- . Mast cells in the brain: evidence and functional significance. Trends Neurosci. 1996;19:25–31
- . Natural killer T cell activation protects mice against experimental autoimmune encephalomyelitis. J. Exp. Med. 2001;194:1801–1811
- . NK T cell-derived IL-10 is essential for the differentiation of antigen-specific T regulatory cells in systemic tolerance. J. Immunol. 2001;166:42–50
- . Immunology of multiple sclerosis. Annu. Rev. Immunol. 2005;23:683–747
- . Decreased severity of myelin oligodendrocyte glycoprotein peptide 33–35-induced experimental autoimmune encephalomyelitis in mice with a disrupted TCR delta chain gene. Eur. J. Immunol. 1999;29:4060–4071
- . Impaired maturation and altered regulatory function of plasmacytoid dendritic cells in multiple sclerosis. Brain. 2006;129:1293–1305
- . Mast cells in allergy: innate instructors of adaptive responses. Immunobiology. 2007;212:505–519
- . Increased frequency of gamma delta T cells in cerebrospinal fluid and peripheral blood of patients with multiple sclerosis. Reactivity, cytotoxicity, and T cell receptor V gene rearrangements. J. Immunol. 1995;154:4883–4894
- . The regulatory role of natural killer cells in multiple sclerosis. Brain. 2004;127:1917–1927
- . Natural killer type 2 bias in remission of multiple sclerosis. J. Clin. Invest. 2001;107:R23–29
- . Mast cells exert effects outside the central nervous system to influence experimental allergic encephalomyelitis disease course. J. Immunol. 2003;171:4385–4391
- . Mitomycin C-treated dendritic cells inactivate autoreactive T cells: toward the development of a tolerogenic vaccine in autoimmune diseases. Proc. Natl. Acad. Sci. U. S. A. 2008;105:18442–18447
- . Synergistic action of estradiol and myelin basic protein on mast cell secretion and brain myelin changes resembling early stages of demyelination. Neuroscience. 1993;57:861–871
- . Human mast cells stimulate activated T cells: implications for multiple sclerosis. Ann. N. Y. Acad. Sci. 2008;1144:74–82
- . Identification of IgE-positive cells and mast cells in frozen sections of multiple sclerosis brains. J. Neuroimmunol. 1990;30:169–177
- . Characterization and distribution of lymphocyte subpopulations in multiple sclerosis plaques versus autoimmune demyelinating lesions. Springer Semin. Immunopathol. 1985;8:71–95
- . NKT cells prevent chronic joint inflammation after infection with Borrelia burgdorferi. Proc. Natl. Acad. Sci. U. S. A. 2008;105:19863–19868
- . Activation of natural killer T cells by glycolipids. Methods Enzymol. 2006;417:185–201
- . Cutting edge: the mechanism of invariant NKT cell responses to viral danger signals. J. Immunol. 2008;181:4452–4456
- . IL-23 is increased in dendritic cells in multiple sclerosis and down-regulation of IL-23 by antisense oligos increases dendritic cell IL-10 production. J. Immunol. 2006;176:7768–7774
- . Increased IL-23 secretion and altered chemokine production by dendritic cells upon CD46 activation in patients with multiple sclerosis. J. Neuroimmunol. 2008;195:140–145
- . NK-dependent DC maturation is mediated by TNFalpha and IFNgamma released upon engagement of the NKp30 triggering receptor. Blood. 2005;106:566–571
- . The small subset of CD56brightCD16- natural killer cells is selectively responsible for both cell proliferation and interferon-gamma production upon interaction with dendritic cells. Eur. J. Immunol. 2004;34:1715–1722
- . Differential effects of IL-21 during initiation and progression of autoimmunity against neuroantigen. J. Immunol. 2005;174:2696–2701
- . Natural-killer cells and dendritic cells: “l'union fait la force”. Blood. 2005;106:2252–2258
- . Multiple sclerosis is an inflammatory T-cell-mediated autoimmune disease. Arch. Neurol. 2004;61:1613–1615
- . A shift from adaptive to innate immunity: a potential mechanism of disease progression in multiple sclerosis. J. Neurol. 2008;255(Suppl 1):3–11
- . The challenge of multiple sclerosis: how do we cure a chronic heterogeneous disease?. Ann. Neurol. 2009;65:239–248
- . Experimental autoimmune encephalomyelitis induction in naive mice by dendritic cells presenting a self-peptide. Immunol. Cell Biol. 2002;80:14–20
- . Targeting of human dendritic cells by autologous NK cells. J. Immunol. 1999;163:6365–6370
- . In vivo regulation of experimental autoimmune encephalomyelitis by NK cells: alteration of primary adaptive responses. J. Immunol. 2008;180:4495–4506
- . Therapeutic potential of IFN-gamma-modified dendritic cells in acute and chronic experimental allergic encephalomyelitis. Int. Immunol. 2004;16:13–22
- . Mechanism of natural killer (NK) cell regulatory role in experimental autoimmune encephalomyelitis. J. Neuroimmunol. 2005;163:24–30
- . Mechanism of gammadelta T cell-induced human oligodendrocyte cytotoxicity: relevance to multiple sclerosis. J. Neuroimmunol. 1998;87:49–61
- . Regulation of experimental autoimmune encephalomyelitis by natural killer (NK) cells. J. Exp. Med. 1997;186:1677–1687
- . Mature bone marrow-derived dendritic cells polarize Th2 response and suppress experimental autoimmune encephalomyelitis. Mult. Scler. 2002;8:463–468
- . NK cells and Treg cells: a fascinating dance cheek to cheek. Eur. J. Immunol. 2008;38:2942–2945
PII: S0165-5728(09)00430-5
doi: 10.1016/j.jneuroim.2009.10.015
© 2009 Elsevier B.V. All rights reserved.
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Journal of Neuroimmunology
Volume 221, Issue 1
, Pages 7-14
, 15 April 2010
