Journal of Neuroimmunology
Volume 218, Issue 1 , Pages 57-66, 25 January 2010

Mast cell adhesion induces cytoskeletal modifications and programmed cell death in oligodendrocytes

  • Nevenka Medic

      Affiliations

    • Department of Life Sciences, University of Trieste, via A. Valerio, 28, 34127, Trieste, Italy
    • ,
  • Paola Lorenzon

      Affiliations

    • Department of Life Sciences, University of Trieste, via A. Valerio, 28, 34127, Trieste, Italy
    • ,
  • Francesca Vita

      Affiliations

    • Department of Life Sciences, University of Trieste, via A. Valerio, 28, 34127, Trieste, Italy
    • ,
  • Elisa Trevisan

      Affiliations

    • Department of Biomedicine, University of Trieste, via A. Manzoni, 16, 34138 Trieste, Italy
    • ,
  • Anna Marchioli

      Affiliations

    • Department of Life Sciences, University of Trieste, via A. Valerio, 28, 34127, Trieste, Italy
    • ,
  • Maria Rosa Soranzo

      Affiliations

    • Department of Life Sciences, University of Trieste, via A. Valerio, 28, 34127, Trieste, Italy
    • ,
  • Elsa Fabbretti

      Affiliations

    • International School of Advanced Studies (SISSA), Basovizza, Trieste, Italy
    • ,
  • Giuliano Zabucchi

      Affiliations

    • Department of Life Sciences, University of Trieste, via A. Valerio, 28, 34127, Trieste, Italy
    • Corresponding Author InformationCorresponding author. Tel.: +39 0 40 558 4032; fax: +39 0 40 558 4023.

Received 7 July 2009; received in revised form 13 October 2009; accepted 13 October 2009. published online 11 November 2009.

Abstract 

In this paper we show that rat peritoneal mast cells (RPMC) adhere to rat oligodendrocytes (ODC) in culture and switch on a bi-directional signal affecting both adhering cell and its target. Following heterotypic interaction, RPMC release granule content and ODC show morphological changes and enter the apoptotic programme. Altogether, these findings indicate that the interaction of MC with ODC could play a role in the mechanism of CNS damage induced by the inflammatory reaction.

Keywords: Mast cell, Oligodendrocyte, Peptidyl-arginyl-deiminase, Cytoskeleton

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PII: S0165-5728(09)00403-2

doi:10.1016/j.jneuroim.2009.10.011

Journal of Neuroimmunology
Volume 218, Issue 1 , Pages 57-66, 25 January 2010

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