BAFF aids generation of IgG anti-ganglioside antibodies in response to Campylobacter jejuni lipo-oligosaccharide

Matsumoto, Yukie; Kobata, Tetsuji; Odaka, Masaaki; Furukawa, Koichi; Hirata, Koichi; Yuki, Nobuhiro

doi:10.1016/j.jneuroim.2009.10.010

« Previous Next »Journal of Neuroimmunology
Volume 218, Issue 1 , Pages 67-72, 25 January 2010

BAFF aids generation of IgG anti-ganglioside antibodies in response to Campylobacter jejuni lipo-oligosaccharide

Yukie Matsumoto
- Department of Neurology and Research Institute for Neuroimmunological Diseases, Dokkyo Medical University School of Medicine, Tochigi, Japan
Tetsuji Kobata
- Department of Immunology, Dokkyo Medical University School of Medicine, Tochigi, Japan
Masaaki Odaka
- Department of Neurology and Research Institute for Neuroimmunological Diseases, Dokkyo Medical University School of Medicine, Tochigi, Japan
Koichi Furukawa
- Department of Biochemistry II, Nagoya University School of Medicine, Nagoya, Japan
Koichi Hirata
- Department of Neurology and Research Institute for Neuroimmunological Diseases, Dokkyo Medical University School of Medicine, Tochigi, Japan
Nobuhiro Yuki
- Department of Neurology and Research Institute for Neuroimmunological Diseases, Dokkyo Medical University School of Medicine, Tochigi, Japan
- Departments of Neurology and Clinical Research, Niigata National Hospital, Niigata, Japan
- Corresponding author. Departments of Neurology and Clinical Research, Niigata National Hospital, 3-52 Akasaka, Kashiwazaki, Niigata 945-8585, Japan.

Received 15 July 2009; received in revised form 15 September 2009; accepted 14 October 2009. published online 09 November 2009.

Abstract

Ganglioside mimicry of Campylobacter jejuni lipo-oligosaccharide (LOS) can induce the production of IgG anti-ganglioside antibodies, but the generation mechanism has yet to be clarified. B-cell activating factor belonging to the TNF family (BAFF) helped murine B cells produce anti-ganglioside antibodies against C. jejuni LOS. In splenocyte culture, however, anti-ganglioside antibodies were produced in the presence of a soluble transmembrane activator and calcium-modulating and cyclophilin ligand interactor immunoadhesin (TACI-Ig), a receptor for BAFF. TACI-Ig adenoviral vectors failed to decrease production of anti-ganglioside antibodies in mice sensitized with C. jejuni LOS and did not alter IgG subclasses, evidence that BAFF aids but is not essential for the generation of IgG anti-ganglioside antibodies in response to C. jejuni LOS.

Keywords: Anti-ganglioside antibody, BAFF, Campylobacter jejuni, Guillain–Barré syndrome, Lipo-oligosaccharide, Molecular mimicry