Journal of Neuroimmunology
Volume 218, Issue 1 , Pages 73-82, 25 January 2010

Circulating brain-reactive autoantibodies and behavioral deficits in the MRL model of CNS lupus

  • S. Williams

      Affiliations

    • Neuroimmunology Labs, School of Life Sciences, Arizona State University, Tempe, AZ, 85287-4501 USA
    • ,
  • B. Sakic

      Affiliations

    • Department of Psychiatry & Behavioral Neuroscience, McMaster University, Hamilton, ON, Canada, L8N3Z5
    • ,
  • S.A. Hoffman

      Affiliations

    • Neuroimmunology Labs, School of Life Sciences, Arizona State University, Tempe, AZ, 85287-4501 USA
    • Corresponding Author InformationCorresponding author. Tel.: +1 480 965 7024; fax: +1 480 965 6899.

Received 13 May 2009; received in revised form 16 September 2009; accepted 13 October 2009. published online 18 November 2009.

Abstract 

Brain-reactive autoantibodies (BRAA) are hypothesized to play a role in the neuropsychiatric manifestations that accompany systemic lupus erythematosus (SLE). The present study tests the proposed relation between circulating BRAA and behavioral deficits in lupus-prone MRL/lpr mice. Two age-matched cohorts born at different times were used to test the relationship in the context of altered disease severity. Significant correlations between autoimmunity and behavior were detected in both cohorts. These results are the first to report correlations between behavior and autoantibodies to integral membrane proteins of brain, supporting the hypothesis that BRAA contribute to the behavioral dysfunction seen in lupus.

Keywords: Brain-reactive autoantibodies, Lupus, CNS lupus, Behavior, MRL mice

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PII: S0165-5728(09)00400-7

doi:10.1016/j.jneuroim.2009.10.008

Journal of Neuroimmunology
Volume 218, Issue 1 , Pages 73-82, 25 January 2010

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