Journal of Neuroimmunology
Volume 217, Issue 1 , Pages 65-73, 10 December 2009

Autoantibodies to the δ-opioid receptor function as opioid agonists and display immunomodulatory activity

  • Parvathi Ranganathan

      Affiliations

    • Department of Immunobiology, University of Arizona, 1656 E. Mabel Street, PO Box 245221, Tucson, Arizona 85724, USA
    • ,
  • Hao Chen

      Affiliations

    • Department of Immunobiology, University of Arizona, 1656 E. Mabel Street, PO Box 245221, Tucson, Arizona 85724, USA
    • ,
  • Miranda K. Adelman

      Affiliations

    • Arizona Arthritis Center, University of Arizona, 1656 E. Mabel Street, PO Box 245221, Tucson, Arizona 85724, USA
    • ,
  • Samuel F. Schluter

      Affiliations

    • Department of Immunobiology, University of Arizona, 1656 E. Mabel Street, PO Box 245221, Tucson, Arizona 85724, USA
    • Corresponding Author InformationCorresponding author. Tel.: +1 520 626 7013; fax: +1 520 626 2100.

Received 21 August 2009; received in revised form 7 October 2009; accepted 9 October 2009. published online 02 November 2009.

Abstract 

In this report, we show that affinity purified human anti-delta opioid receptor (DOR) autoantibodies from IVIG are specific to DOR and possess agonistic properties displayed by their ability to dramatically decrease forskolin stimulated cAMP accumulation. Anti-DOR autoantibody also caused phosphorylation of the opioid receptor. Anti-DOR autoantibody treatment showed a significant reduction in CXCR4 gene expression as well as surface protein expression. In contrast, anti-DOR autoantibody treatment significantly upregulated CCR5 gene and protein expression. The presence of anti-DOR autoantibodies in IVIG and their potent immunomodulatory activity is further evidence to support the cross-talk between the neuroendocrine and immune systems.

Keywords: Opioid receptors, Autoantibodies, Immunomodulation

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PII: S0165-5728(09)00399-3

doi:10.1016/j.jneuroim.2009.10.007

Journal of Neuroimmunology
Volume 217, Issue 1 , Pages 65-73, 10 December 2009

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