Journal of Neuroimmunology
Volume 218, Issue 1 , Pages 134-139 , 25 January 2010

Clonally expanded plasma cells in the cerebrospinal fluid of patients with central nervous system autoimmune demyelination produce “oligoclonal bands”

  • Hans-Christian von Büdingen

      Affiliations

    • Dept. of Neurology, University Hospital Zürich, Frauenklinikstrasse 26, 8091 Zürich, Switzerland
    • Dept. of Neurology, University of California, San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA
    • Corresponding Author InformationCorresponding author. Dept. of Neurology, University of California, San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA. Tel.: +1 415 476 9046; fax: +1 415 476 5229.
    • Equal contribution.
    • ,
  • Monica Gulati

      Affiliations

    • Dept. of Neurology, University Hospital Zürich, Frauenklinikstrasse 26, 8091 Zürich, Switzerland
    • Equal contribution.
    • ,
  • Sandra Kuenzle

      Affiliations

    • Dept. of Neurology, University Hospital Zürich, Frauenklinikstrasse 26, 8091 Zürich, Switzerland
    • ,
  • Katja Fischer

      Affiliations

    • Dept. of Neurology, University Hospital Zürich, Frauenklinikstrasse 26, 8091 Zürich, Switzerland
    • ,
  • Tobias A. Rupprecht

      Affiliations

    • Dept. of Neurology, University Hospital Zürich, Frauenklinikstrasse 26, 8091 Zürich, Switzerland
    • Dept. of Neurology, Ludwig-Maximilians University, Marchioninistr. 15, 81377 Munich, Germany
    • ,
  • Norbert Goebels

      Affiliations

    • Dept. of Neurology, University Hospital Zürich, Frauenklinikstrasse 26, 8091 Zürich, Switzerland
    • Dept. of Neurology, University Hospital Basel, Petersgraben 4, 4031 Basel, Switzerland
    • Present address: Dept. of Neurology, University of Düsseldorf, Moorenstrasse 5, D-40225 Düsseldorf, Germany

Received 20 July 2009 ,Revised 4 October 2009 ,Accepted 9 October 2009.

References 

  1. Cepok S, Zhou D, Srivastava R, Nessler S, Stei S, Bussow K, et al. Identification of Epstein–Barr virus proteins as putative targets of the immune response in multiple sclerosis. J. Clin. Invest. 2005;115:1352–1360
  2. Franciotta D, Columba-Cabezas S, Andreoni L, Ravaglia S, Jarius S, Romagnolo S, et al. Oligoclonal IgG band patterns in inflammatory demyelinating human and mouse diseases. J. Neuroimmunol. 2008;200:125–128
  3. Giudicelli V, Chaume D, Lefranc MP. IMGT/V-QUEST, an integrated software program for immunoglobulin and T cell receptor V-J and V-D-J rearrangement analysis. Nucleic Acids Res. 2004;32:W435–440
  4. Hauser SL, Waubant E, Arnold DL, Vollmer T, Antel J, Fox RJ, et al. B-cell depletion with rituximab in relapsing–remitting multiple sclerosis. N. Engl. J. Med. 2008;358:676–688
  5. Karni A, Bakimer-Kleiner R, Abramsky O, Ben-Nun A. Elevated levels of antibody to myelin oligodendrocyte glycoprotein is not specific for patients with multiple sclerosis. Arch. Neurol. 1999;56:311–315
  6. Kuhle J, Pohl C, Mehling M, Edan G, Freedman MS, Hartung HP, et al. Lack of association between antimyelin antibodies and progression to multiple sclerosis. N. Engl. J. Med. 2007;356:371–378
  7. Lefranc MP, Giudicelli V, Ginestoux C, Jabado-Michaloud J, Folch G, Bellahcene F, et al. IMGT, the international ImMunoGeneTics information system. Nucleic Acids Res. 2009;37:D1006–1012
  8. Lindert RB, Haase CG, Brehm U, Linington C, Wekerle H, Hohlfeld R. Multiple sclerosis: B- and T-cell responses to the extracellular domain of the myelin oligodendrocyte glycoprotein. Brain. 1999;122:2089–2100
  9. Link H. The immune response in human demyelinating diseases. Adv. Exp. Med. Biol. 1978;100:529–543
  10. Mantegazza R, Cristaldini P, Bernasconi P, Baggi F, Pedotti R, Piccini I, et al. Anti-MOG autoantibodies in Italian multiple sclerosis patients: specificity, sensitivity and clinical association. Int. Immunol. 2004;16:559–565
  11. Markovic M, Trajkovic V, Drulovic J, Mesaros S, Stojsavljevic N, Dujmovic I, et al. Antibodies against myelin oligodendrocyte glycoprotein in the cerebrospinal fluid of multiple sclerosis patients. J. Neurol. Sci. 2003;211:67–73
  12. Obermeier B, Mentele R, Malotka J, Kellermann J, Kumpfel T, Wekerle H, et al. Matching of oligoclonal immunoglobulin transcriptomes and proteomes of cerebrospinal fluid in multiple sclerosis. Nat. Med. 2008;14:688–693
  13. Owens GP, Ritchie AM, Burgoon MP, Williamson RA, Corboy JR, Gilden DH. Single-cell repertoire analysis demonstrates that clonal expansion is a prominent feature of the B cell response in multiple sclerosis cerebrospinal fluid. J. Immunol. 2003;171:2725–2733
  14. Owens GP, Winges KM, Ritchie AM, Edwards S, Burgoon MP, Lehnhoff L, et al. VH4 gene segments dominate the intrathecal humoral immune response in multiple sclerosis. J. Immunol. 2007;179:6343–6351
  15. Owens GP, Bennett JL, Lassmann H, O'Connor KC, Ritchie AM, Shearer A, et al. Antibodies produced by clonally expanded plasma cells in multiple sclerosis cerebrospinal fluid. Ann. Neurol. 2009;65:639–649
  16. Reindl M, Linington C, Brehm U, Egg R, Dilitz E, Deisenhammer F, et al. Antibodies against the myelin oligodendrocyte glycoprotein and the myelin basic protein in multiple sclerosis and other neurological diseases: a comparative study. Brain. 1999;122:2047–2056
  17. Ritchie AM, Gilden DH, Williamson RA, Burgoon MP, Yu X, Helm K, et al. Comparative analysis of the CD19+ and CD138+ cell antibody repertoires in the cerebrospinal fluid of patients with multiple sclerosis. J. Immunol. 2004;173:649–656
  18. Storch MK, Piddlesden S, Haltia M, Iivanainen M, Morgan P, Lassmann H. Multiple sclerosis: in situ evidence for antibody- and complement- mediated demyelination. Ann. Neurol. 1998;43:465–471
  19. Sun J, Link H, Olsson T, Xiao BG, Andersson G, Ekre HP, et al. T and B cell responses to myelin-oligodendrocyte glycoprotein in multiple sclerosis. J. Immunol. 1991;146:1490–1495
  20. Tourtellotte WW, Potvin AR, Fleming JO, Murthy KN, Levy J, Syndulko K, et al. Multiple sclerosis: measurement and validation of central nervous system IgG synthesis rate. Neurology. 1980;30:240–244
  21. von Büdingen HC, Harrer MD, Kuenzle S, Meier M, Goebels N. Clonally expanded plasma cells in the cerebrospinal fluid of MS patients produce myelin-specific antibodies. Eur. J. Immunol. 2008;38:2014–2023
  22. Walsh MJ, Tourtellotte WW. Temporal invariance and clonal uniformity of brain and cerebrospinal IgG, IgA, and IgM in multiple sclerosis. J. Exp. Med. 1986;163:41–53
  23. Wardemann H, Yurasov S, Schaefer A, Young JW, Meffre E, Nussenzweig MC. Predominant autoantibody production by early human B cell precursors. Science. 2003;301:1374–1377
  24. Winges KM, Gilden DH, Bennett JL, Yu X, Ritchie AM, Owens GP. Analysis of multiple sclerosis cerebrospinal fluid reveals a continuum of clonally related antibody-secreting cells that are predominantly plasma blasts. J. Neuroimmunol. 2007;192:226–234
  25. Xiao BG, Linington C, Link H. Antibodies to myelin-oligodendrocyte glycoprotein in cerebrospinal fluid from patients with multiple sclerosis and controls. J. Neuroimmunol. 1991;31:91–96

PII: S0165-5728(09)00397-X

doi: 10.1016/j.jneuroim.2009.10.005

Journal of Neuroimmunology
Volume 218, Issue 1 , Pages 134-139 , 25 January 2010

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