Journal of Neuroimmunology
Volume 217, Issue 1 , Pages 80-84, 10 December 2009

Conversion of peripheral CD4+CD25 T cells to CD4+CD25+ regulatory T cells by IFN-γ in patients with Guillain-Barré syndrome

Department of Neurology, the Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, 150086, PR China

Received 11 August 2009; received in revised form 27 September 2009; accepted 2 October 2009. published online 26 October 2009.

Abstract 

CD4+CD25 T cells from 25 Guillain-Barré syndrome (GBS) patients were stimulated by IFN-γ to generate the induced CD4+CD25+ regulatory T cells (iTregs). Then, their phenotypical and functional characterizations were analyzed. Results show that iTregs can be generated from CD4+CD25 T cells in GBS patients by IFN-γ in the presence of activating anti-CD3 and anti-CD28 antibodies in vitro. When CD4+CD25 T cells are stimulated by 40ng/ml IFN-γ for 3days, the ratio of conversion is the highest under this condition and iTregs are similar to naturally occurring CD4+CD25+ regulatory T cells of healthy donors phenotypically and functionally.

Keywords: Guillain-Barré syndrome (GBS), IFN-γ, CD4+CD25 T cells, Induced CD4+CD25+ regulatory T cells (iTregs), CD4+CD25+ regulatory T cells (CD4+CD25+ Tregs)

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PII: S0165-5728(09)00392-0

doi:10.1016/j.jneuroim.2009.10.001

Journal of Neuroimmunology
Volume 217, Issue 1 , Pages 80-84, 10 December 2009