Journal of Neuroimmunology
Volume 217, Issue 1 , Pages 12-13 , 10 December 2009

Tumour-induced anti-Hu autoimmunity in mice — A step towards animal models of paraneoplastic disease

  • Franz Blaes

      Affiliations

    • Corresponding Author InformationTel.: +49 641 9945400; fax: +49 641 9945449.

Received 11 September 2009 ,Revised 14 September 2009 ,Accepted 14 September 2009.

References 

  1. Antic D, Keene JD. Embryonic lethal abnormal visual RNA-binding proteins involved in growth, differentiation, and posttranscriptional gene expression. Am. J. Hum. Genet. 1997;61:273–278
  2. Carpentier AF, Rosenfeld MR, Delattre JY, Whalen RG, Posner JB, Dalmau J. DNA vaccination with HuD inhibits growth of a neuroblastoma in mice. Clin. Cancer Res. 1998;4:2819–2824
  3. Dalmau J, Furneaux HM, Gralla RJ, Kris MG, Posner JB. Detection of the anti-Hu antibody in the serum of patients with small cell lung cancer — a quantitative western blot analysis. Ann. Neurol. 1990;27:544–552
  4. Dalmau J, Furneaux HM, Rosenblum MK, Graus F, Posner JB. Detection of the anti-Hu antibody in specific regions of the nervous system and tumor from patients with paraneoplastic encephalomyelitis/sensory neuronopathy. Neurology. 1991;41:1757–1764
  5. Graus F, Dalmou J, Rene R, Tora M, Malats N, Verschuuren JJ, et al. Anti-Hu antibodies in patients with small-cell lung cancer: association with complete response to therapy and improved survival. J. Clin. Oncol. 1997;15:2866–2872
  6. Graus F, Delattre JY, Antoine JC, Dalmau J, Giometto B, Grisold W, et al. Recommended diagnostic criteria for paraneoplastic neurological syndromes. J. Neurol. Neurosurg. Psychiatry. 2004;75:1135–1140
  7. Kazarian M, Calbo J, Proost N, Carpenter CL, Berns A, Laird-Offringa IA. Immune response in lung cancer mouse model mimics human anti-Hu reactivity. J. Neuroimmunol. 2009;217:38–45(this issue)
  8. Meuwissen R, Linn SC, Linnoila RI, Zevenhoven J, Mooi WJ, Berns A. Induction of small cell lung cancer by somatic inactivation of both Trp53 and Rb1 in a conditional mouse model. Cancer Cell. 2003;4:181–189
  9. Pellkofer H, Schubart AS, Hoftberger R, Schutze N, Pagany M, Schuller M, et al. Modelling paraneoplastic CNS disease: T-cells specific for the onconeuronal antigen PNMA1 mediate autoimmune encephalomyelitis in the rat. Brain. 2004;127:1822–1830
  10. Roberts WK, Deluca IJ, Thomas A, Fak J, Williams T, Buckley N, et al. Patients with lung cancer and paraneoplastic Hu syndrome harbor HuD-specific type 2 CD8+ T cells. J. Clin. Invest. 2009;119:2042–2051
  11. Sillevis Smitt PA, Manley GT, Posner JB. Immunization with the paraneoplastic encephalomyelitis antigen HuD does not cause neurologic disease in mice. Neurology. 1995;45:1873–1878
  12. Tanaka K, Tanaka M, Onodera O, Igarashi S, Miyatake T, Tsuji S. Passive transfer and active immunization with the recombinant leucine-zipper (Yo) protein as an attempt to establish an animal model of paraneoplastic cerebellar degeneration. J. Neurol. Sci. 1994;127:153–158
  13. Tanaka K, Tanaka M, Igarashi S, Onodera O, Miyatake T, Tsuji S. Trial to establish an animal model of paraneoplastic cerebellar degeneration with anti-Yo antibody. 2. Passive transfer of murine mononuclear cells activated with recombinant Yo protein to paraneoplastic cerebellar degeneration lymphocytes in severe combined immunodeficiency mice. Clin. Neurol. Neurosurg. 1995;97:101–105
  14. Toothaker TB, Rubin M. Paraneoplastic neurological syndromes: a review. Neurologist. 2009;15:21–33
  15. Verschuuren JJ, Dalmau J, Hoard R, Posner JB. Paraneoplastic anti-Hu serum: studies on human tumor cell lines. J. Neuroimmunol. 1997;79:202–210

PII: S0165-5728(09)00358-0

doi: 10.1016/j.jneuroim.2009.09.012

Journal of Neuroimmunology
Volume 217, Issue 1 , Pages 12-13 , 10 December 2009