Journal of Neuroimmunology
Volume 215, Issue 1 , Pages 73-83, 30 October 2009

Transplanted myogenic progenitor cells express neuronal markers in the CNS and ameliorate disease in Experimental Autoimmune Encephalomyelitis

  • Rina Aharoni

      Affiliations

    • The Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel
    • Corresponding Author InformationCorresponding author. The Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel, 76100. Tel.: +972 8 9342997; fax: +972 8 9469712.
    • ,
  • Elizabeta Aizman

      Affiliations

    • The Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel
    • ,
  • Ora Fuchs

      Affiliations

    • Molecular Cell Biology, The Weizmann Institute of Science, Rehovot, Israel
    • ,
  • Ruth Arnon

      Affiliations

    • The Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel
    • ,
  • David Yaffe

      Affiliations

    • Molecular Cell Biology, The Weizmann Institute of Science, Rehovot, Israel
    • ,
  • Rachel Sarig

      Affiliations

    • Molecular Cell Biology, The Weizmann Institute of Science, Rehovot, Israel

Received 21 June 2009; received in revised form 23 August 2009; accepted 24 August 2009. published online 22 September 2009.

Abstract 

This study explores the potential of non-neural progenitor cells for CNS cell therapy. Muscle progenitor cells (MPCs), transplanted either intraventricularly or intraperitonealy, incorporated into the CNS of EAE-induced but not of naïve mice. Some of the migrating MPCs expressed the neuronal marker β-III-Tubulin and gained neuronal morphology. Co-treatment of transplanted mice with the immunomodulatory agent glatiramer acetate (GA, Copaxone) resulted in improved MPCs incorporation and differentiation towards the neuronal pathway. The therapeutic potential of myogenic progenitor cells was demonstrated by amelioration of clinical symptoms and reduced mortality in EAE mice, as well as by expression of IL-10, TGF-β, and the neurotrophin-BDNF.

Keywords: Myoblasts, Progenitor cells, Neurons, Multiple Sclerosis, Experimental Autoimmune Encephalomyelitis, Glatiramer acetate

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PII: S0165-5728(09)00315-4

doi:10.1016/j.jneuroim.2009.08.009

Journal of Neuroimmunology
Volume 215, Issue 1 , Pages 73-83, 30 October 2009

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