« Previous
Next »
Journal of Neuroimmunology
Volume 215, Issue 1
, Pages 49-64
, 30 October 2009
Regulation of CXCL12 and CXCR4 expression by human brain endothelial cells and their role in CD4+ and CD8+ T cell adhesion and transendothelial migration
References
- . Chemokines and their receptors in neurobiology: perspectives in physiology and homeostasis. J. Neuroimmunol. 2000;104:92–97
- . Human chemokines: an update. Annu. Rev. Immunol. 1997;15:675–705
- . Chemokines and their receptors in the central nervous system. Front. Neuroendocrinol. 2001;22:147–184
- . The chemokine SDF-1/CXCL12 binds to and signals through the orphan receptor RDC1 in T lymphocytes. J. Biol. Chem. 2005;280:35760–35766
- . CXCR4-activated astrocyte glutamate release via TNFalpha: amplification by microglia triggers neurotoxicity. Nat. Neurosci. 2001;4:702–710
- . Stromal cell-derived factor 1 (CXCL12) induces human cell migration into human lymph nodes transplanted into SCID mice. J Immunol. 2002;168:4308–4317
- . A highly efficacious lymphocyte chemoattractant, stromal cell-derived factor 1 (SDF-1). J Exp Med. 1996;184:1101–1109
- . The HIV coreceptors CXCR4 and CCR5 are differentially expressed and regulated on human T lymphocytes. Proc. Natl. Acad. Sci. U. S. A. 1997;94:1925–1930
- . A novel chemokine receptor for SDF-1 and I-TAC involved in cell survival, cell adhesion, and tumor development. J. Exp. Med. 2006;203:2201–2213
- . A role for CXCL12 (SDF-1alpha) in the pathogenesis of multiple sclerosis: regulation of CXCL12 expression in astrocytes by soluble myelin basic protein. J. Neuroimmunol. 2006;177:27–39
- . T lymphocyte trafficking: a novel target for neuroprotection in traumatic brain injury. J. Neurotrauma. 2007;24:1295–1307
- . Chemokine signaling and integrin activation in lymphocyte migration into the inflamed brain. J. Neuroimmunol. 2008;198:20–26
- . Regulation of chemokine-induced transendothelial migration of T lymphocytes by endothelial activation: differential effects on naive and memory T cells. J. Leukoc. Biol. 2000;67:825–833
- . Culture and characterization of microvascular endothelial cells derived from human brain. Lab. Invest. 1991;64:425–436
- . The kinetics, function, and regulation of P-selectin expressed by human brain microvessel endothelial cells in primary culture. Microvasc. Res. 2001;62:335–345
- . Molecular mechanisms involved in T cell migration across the blood–brain barrier. J. Neural. Transm. 2006;113:477–485
- . Expression of stromal-derived factor-1 is decreased by IL-1 and TNF and in dermal wound healing. J. Immunol. 2001;166:5749–5754
- . Endothelial cells differentially express functional CXC-chemokine receptor-4 (CXCR-4/fusin) under the control of autocrine activity and exogenous cytokines. Biochem. Biophys. Res. Commun. 1998;247:38–45
- . Intracellular and surface expression of the HIV-1 coreceptor CXCR4/fusin on various leukocyte subsets: rapid internalization and recycling upon activation. J. Immunol. 1998;160:1522–1531
- . Cloning and characterization of SDF-1gamma, a novel SDF-1 chemokine transcript with developmentally regulated expression in the nervous system. Eur. J. NeuroSci. 2000;12:1857–1866
- . TNF-induced microvascular pathology: active role for platelets and importance of the LFA-1/ICAM-1 interaction. Eur. Cytokine Netw. 1993;4:415–419
- . Chemokine receptors in human endothelial cells. Functional expression of CXCR4 and its transcriptional regulation by inflammatory cytokines. J. Biol. Chem. 1998;273:4282–4287
- . CXCR4 undergoes complex lineage and inducing agent-dependent dissociation of expression and functional responsiveness to SDF-1alpha during myeloid differentiation. J. Leukoc. Biol. 2001;70:431–438
- . TNF-alpha down-regulates CXCR4 expression in primary murine astrocytes. Brain Res. 2001;888:1–10
- . Regulation of human chemokine receptors CXCR4. Role of phosphorylation in desensitization and internalization. J. Biol. Chem. 1997;272:28726–28731
- . SDF-1 (CXCL12) is upregulated in the ischemic penumbra following stroke: association with bone marrow cell homing to injury. J. Neuropathol. Exp. Neurol. 2004;63:84–96
- . Chemokines, chemokine receptors and adhesion molecules on different human endothelia: discriminating the tissue-specific functions that affect leucocyte migration. Clin. Exp. Immunol. 2003;134:431–441
- . Effects of interferon-gamma on primary cultures of human brain microvessel endothelial cells. Am. J. Pathol. 1993;142:1265–1278
- . CXCL12-CXCR4 engagement is required for migration of cutaneous dendritic cells. Am. J. Pathol. 2007;171:1249–1257
- . Alteration in glycosaminoglycan metabolism and surface charge on human umbilical vein endothelial cells induced by cytokines, endotoxin and neutrophils. J. Cell Sci. 1992;102(Pt 4):821–832
- . Chemokines in multiple sclerosis: CXCL12 and CXCL13 up-regulation is differentially linked to CNS immune cell recruitment. Brain. 2006;129:200–211
- . How do stem cells find their way home?. Blood. 2005;106:1901–1910
- . Encephalitogenic T cells use LFA-1 for transendothelial migration but not during capture and initial adhesion strengthening in healthy spinal cord microvessels in vivo. Eur. J. Immunol. 2002;32:3598–3606
- . The Pathology of Multiple Sclerosis. In: Compston A, Confavreus C, Lassmann H, McDonald I, Miller DH, Noseworthy J, Smith K, Wekerle H editor. McAlpine's Multiple Sclerosis. Elsevier Inc; 2006;p. 557–599
- . Right on the spot. Chemokine triggering of integrin-mediated arrest of rolling leukocytes. Thromb. Haemost. 2006;95:5–11
- . CXCR-4 (Fusin), a co-receptor for the type 1 human immunodeficiency virus (HIV-1), is expressed in the human brain in a variety of cell types, including microglia and neurons. Am. J. Pathol. 1997;151:1035–1042
- . Multiple roles of chemokine CXCL12 in the central nervous system: a migration from immunology to neurobiology. Prog. Neurobiol. 2008;84:116–131
- . Molecular mechanisms of leukocyte recruitment: organ-specific mechanisms of action. Thromb. Haemost. 2003;89:213–220
- . Chemokine receptors that mediate B cell homing to secondary lymphoid tissues are highly expressed in B cell chronic lymphocytic leukemia and non-Hodgkin lymphomas with widespread nodular dissemination. J. Leukoc. Biol. 2004;76:462–471
- . Impaired B-lymphopoiesis, myelopoiesis, and derailed cerebellar neuron migration in CXCR4- and SDF-1-deficient mice. Proc. Natl. Acad. Sci. U. S. A. 1998;95:9448–9453
- . Monocyte migration and LFA-1-mediated attachment to brain microvascular endothelia is regulated by SDF-1 alpha through Lyn kinase. J. Immunol. 2008;181:4632–4637
- . Pathological expression of CXCL12 at the blood–brain barrier correlates with severity of multiple sclerosis. Am. J. Pathol. 2008;172:799–808
- . CXCL12 limits inflammation by localizing mononuclear infiltrates to the perivascular space during experimental autoimmune encephalomyelitis. J. Immunol. 2006;177:8053–8064
- . SDF-1 activity on microvascular endothelial cells: consequences on angiogenesis in in vitro and in vivo models. Thromb. Res. 2000;99:587–594
- . Involvement of chemokine receptors in breast cancer metastasis. Nature. 2001;410:50–56
- . Migration of leukocytes across endothelium and beyond: molecules involved in the transmigration and fate of monocytes. J. Leukoc. Biol. 1999;66:698–704
- . Role of chemokine SDF-1/PBSF and its receptor CXCR4 in blood vessel development. Ann. N. Y. Acad. Sci. 2001;947:112–115discussion 115–116
- . Cutting edge: stromal cell-derived factor-1 is a costimulator for CD4+ T cell activation. J. Immunol. 2000;164:5010–5014
- . Chemokine receptor internalization and intracellular trafficking. Cytokine Growth Factor Rev. 2005;16:637–658
- . Proteoglycans guide SDF-1-induced migration of hematopoietic progenitor cells. J. Leukoc. Biol. 2002;72:353–362
- . Interleukin-6 and cAMP induce stromal cell-derived factor-1 chemotaxis in astroglia by up-regulating CXCR4 cell surface expression. Implications for brain inflammation. J. Biol. Chem. 2002;277:39801–39808
- . Expression of stromal cell-derived factor-1 and CXCR4 chemokine receptor mRNAs in cultured rat glial and neuronal cells. Neurosci. Lett. 1998;249:163–166
- . Expression of chemokine receptors CXCR4 and CCR5 in HIV-1-infected and uninfected individuals. J. Immunol. 1998;161:3195–3201
- . Active movement of T cells away from a chemokine. Nat. Med. 2000;6:543–548
- . Control of lymphocyte migration into brain: selective interactions of lymphocyte subpopulations with brain endothelium. Immunology. 1991;72:393–398
- . Inhibition of antigen-specific T cell trafficking into the central nervous system via blocking PECAM1/CD31 molecule. J. Neuropathol. Exp. Neurol. 2001;60:798–807
- . The beta chemokines CCL4 and CCL5 enhance adhesion of specific CD4+ T cell subsets to human brain endothelial cells. J. Neuropathol. Exp. Neurol. 2004;63:350–362
- . Identification and localization of the cytokine SDF1 and its receptor, CXC chemokine receptor 4, to regions of necrosis and angiogenesis in human glioblastoma. Clin. Cancer Res. 2000;6:102–111
- . Role of chemokines in angiogenesis: CXCL12/SDF-1 and CXCR4 interaction, a key regulator of endothelial cell responses. Microcirculation. 2003;10:359–370
- . Shear flow-dependent integration of apical and subendothelial chemokines in T-cell transmigration: implications for locomotion and the multistep paradigm. Blood. 2007;109:1381–1386
- . Expression of the beta-chemokines RANTES and MIP-1 beta by human brain microvessel endothelial cells in primary culture. J. Neuropathol. Exp. Neurol. 2000;59:339–352
- . Phorbol esters and SDF-1 induce rapid endocytosis and down modulation of the chemokine receptor CXCR4. J. Cell Biol. 1997;139:651–664
- . A dual role for the SDF-1/CXCR4 chemokine receptor system in adult brain: isoform-selective regulation of SDF-1 expression modulates CXCR4-dependent neuronal plasticity and cerebral leukocyte recruitment after focal ischemia. J. Neurosci. 2002;22:5865–5878
- . Functional expression of the CXC-chemokine receptor-4/fusin on mouse microglial cells and astrocytes. J. Immunol. 1997;159:905–911
- . Spontaneous and ligand-induced trafficking of CXC-chemokine receptor 4. J. Biol. Chem. 1998;273:15883–15886
- . Leukocyte–endothelium interaction promotes SDF-1-dependent polarization of CXCR4. J. Biol. Chem. 2003;278:30302–30310
- . Distinct mechanisms of agonist-induced endocytosis for human chemokine receptors CCR5 and CXCR4. Mol. Biol. Cell. 2003;14:3305–3324
- . Upregulation of intercellular adhesion molecule-1 (ICAM-1) expression in primary cultures of human brain microvessel endothelial cells by cytokines and lipopolysaccharide. J. Neuroimmunol. 1992;39:11–21
- . Expression of vascular cell adhesion molecule-1 (VCAM-1) by human brain microvessel endothelial cells in primary culture. Microvasc. Res. 1995;49:325–339
- . Platelet/endothelial cell adhesion molecule-1 (PECAM-1) expression by human brain microvessel endothelial cells in primary culture. Brain Res. 1996;731:217–220
- . Regualtion by cytokines and lipopolysaccharide of E-selectin expression by human brain microvessel endothelial cells in primary culture. J. Neuropathol. Exp. Neurol. 1996;55:225–235
- . In vitro adhesion and migration of T lymphocytes across monolayers of human brain microvessel endothelial cells: regulation by ICAM-1, VCAM-1, E-selectin and PECAM-1. J. Neuropathol. Exp. Neurol. 1999;58:138–152
- . Cytokines, nitric oxide, and cGMP modulate the permeability of an in vitro model of the human blood–brain barrier. Exp. Neurol. 2004;190:446–455
- . HIV-induced metalloproteinase processing of the chemokine stromal cell derived factor-1 causes neurodegeneration. Nat. Neurosci. 2003;6:1064–1071
- . Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development. Nature. 1998;393:595–599
PII: S0165-5728(09)00307-5
doi: 10.1016/j.jneuroim.2009.08.003
© 2009 Elsevier B.V. All rights reserved.
« Previous
Next »
Journal of Neuroimmunology
Volume 215, Issue 1
, Pages 49-64
, 30 October 2009
