Evaluation of humoral immune response in adaptive immunity in ALS patients during disease progression

Saleh, Islam A.; Zesiewicz, Theresa; Xie, Yong; Sullivan, Kelly L.; Miller, Amber M.; Kuzmin-Nichols, Nicole; Sanberg, Paul R.; Garbuzova-Davis, Svitlana

doi:10.1016/j.jneuroim.2009.07.011

« Previous Next »Journal of Neuroimmunology
Volume 215, Issue 1 , Pages 96-101, 30 October 2009

Evaluation of humoral immune response in adaptive immunity in ALS patients during disease progression

Islam A. Saleh
- Center of Excellence for Aging and Brain Repair, University of South Florida, College of Medicine, Tampa, FL 33612, United States
Theresa Zesiewicz
- Department of Neurology, University of South Florida, College of Medicine, Tampa, FL 33612, United States
Yong Xie
- Center of Excellence for Aging and Brain Repair, University of South Florida, College of Medicine, Tampa, FL 33612, United States
Kelly L. Sullivan
- Department of Neurology, University of South Florida, College of Medicine, Tampa, FL 33612, United States
Amber M. Miller
- Department of Neurology, University of South Florida, College of Medicine, Tampa, FL 33612, United States
Nicole Kuzmin-Nichols
- Saneron CCEL Therapeutics, Inc., Tampa, FL 33612, United States
Paul R. Sanberg
- Center of Excellence for Aging and Brain Repair, University of South Florida, College of Medicine, Tampa, FL 33612, United States
- Department of Neurosurgery, University of South Florida, College of Medicine, Tampa, FL 33612, United States
- Department of Molecular Pharmacology and Physiology, University of South Florida, College of Medicine, Tampa, FL 33612, United States
- Department of Pathology and Cell Biology, University of South Florida, College of Medicine, Tampa, FL 33612, United States
- Department of Psychiatry, University of South Florida, College of Medicine, Tampa, FL 33612, United States
Svitlana Garbuzova-Davis
- Center of Excellence for Aging and Brain Repair, University of South Florida, College of Medicine, Tampa, FL 33612, United States
- Department of Neurosurgery, University of South Florida, College of Medicine, Tampa, FL 33612, United States
- Department of Molecular Pharmacology and Physiology, University of South Florida, College of Medicine, Tampa, FL 33612, United States
- Department of Pathology and Cell Biology, University of South Florida, College of Medicine, Tampa, FL 33612, United States
- Corresponding author. Center of Excellence for Aging and Brain Repair Department of Neurosurgery University of South Florida, College of Medicine 12901 Bruce B. Downs Blvd. Tampa, FL 33612, United States. Tel.: +1 813 974 3189; fax: +1 813 974 3078.

Received 22 January 2009; received in revised form 19 July 2009; accepted 21 July 2009. published online 17 August 2009.

Abstract

In ALS, evidence suggests immune reactions in disease pathogenesis. Although immunological changes point to adaptive immune response, whether humoral or cellular response dominates during disease course is unknown. The study aim was to evaluate humoral immune response in ALS patients during disease progression. Circulating immune complexes (CICs), IgG, and IgM in sera of ALS patients and matching controls were evaluated after each of two visits. Results showed significantly elevated CICs and IgG in ALS patient sera. CICs decreased to control levels at the second visit, yet IgG remained higher than controls. Serum IgM was within normal range. Results suggest a humoral immune response initiating adaptive immunity in ALS, however, cellular immune response needs verification.

Keywords: Amyotrophic lateral sclerosis, Humoral immune response, Circulating immune complexes, IgG, IgM