« Previous
Next »
Journal of Neuroimmunology
Volume 215, Issue 1
, Pages 10-24
, 30 October 2009
Encephalitogenic T cells that stably express both T-bet and RORγt consistently produce IFNγ but have a spectrum of IL-17 profiles
References
- . T-cell properties determine disease site, clinical presentation, and cellular pathology of experimental autoimmune encephalomyelitis. Am. J. Pathol. 2004;165:1519–1533
- . Heterogeneity of EAE mediated by multiple distinct T-effector subsets. J. Neuroimmunol. 2007;192:3–12
- . Surface phenotype and antigenic specificity of human interleukin 17-producing T helper memory cells. Nat. Immunol. 2007;8:639–646
- . Phenotypic and functional features of human Th17 cells. J. Exp. Med. 2007;204:1849–1861
- . Highly purified Th17 cells from BDC2.5NOD mice convert into Th1-like cells in NOD/SCID recipient mice. J. Clin. Invest. 2009;119:565–572
- . Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature. 2006;441:235–238
- . Distinct regulation of interleukin-17 in human T helper lymphocytes. Arthritis Rheum. 2007;56:2936–2946
- . Human interleukin 17-producing cells originate from a CD161+CD4+ T cell precursor. J. Exp. Med. 2008;205:1903–1916
- . Both Th1 and th17 are immunopathogenic but differ in other key biological activities. J. Immunol. 2008;180:7414–7422
- . T-bet regulates the fate of Th1 and Th17 lymphocytes in autoimmunity. J. Immunol. 2007;178:1341–1348
- . Expanding the effector CD4 T-cell repertoire: the Th17 lineage. Curr. Opin. Immunol. 2006;18:349–356
- . The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells. Cell. 2006;126:1121–1133
- . Transcriptional regulation of Th17 cell differentiation. Semin. Immunol. 2007;19:409–417
- . Myelin-specific regulatory T cells accumulate in the CNS but fail to control autoimmune inflammation. Nat. Med. 2007;13:423–431
- . IL-23 drives a pathogenic T cell population that induces autoimmune inflammation. J. Exp. Med. 2005;201:233–240
- . Late developmental plasticity in the T helper 17 lineage. Immunity. 2009;30:92–107
- . Psoriasis vulgaris lesions contain discrete populations of Th1 and Th17 T cells. J. Invest. Dermatol. 2008;128:1207–1211
- . Either a Th17 or a Th1 effector response can drive autoimmunity: conditions of disease induction affect dominant effector category. J. Exp. Med. 2008;205:799–810
- . Transforming growth factor-beta induces development of the T(H)17 lineage. Nature. 2006;441:231–234
- . Th17 cells promote pancreatic inflammation but only induce diabetes efficiently in lymphopenic hosts after conversion into Th1 cells. Eur. J. Immunol. 2009;39:216–224
- . T-bet is a critical determinant in the instability of the IL-17-secreting T-helper phenotype. Blood. 2006;108:1595–1601
- . Th17 cell differentiation: the long and winding road. Immunity. 2008;28:445–453
- . Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. J. Immunol. 1986;136:2348–2357
- . Interleukin-17-producing T cells are enriched in the joints of children with arthritis, but have a reciprocal relationship to regulatory T cell numbers. Arthritis Rheum. 2008;58:875–887
- . Essential autocrine regulation by IL-21 in the generation of inflammatory T cells. Nature. 2007;448:480–483
- . A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17. Nat. Immunol. 2005;6:1133–1141
- . Phenotype switching by inflammation-inducing polarized Th17 cells, but not by Th1 cells. J. Immunol. 2008;181:7205–7213
- . Cytokine mediators of Th17 function. Eur. J. Immunol. 2009;39:658–661
- . A rush to judgment on Th17. J. Exp. Med. 2008;205:1517–1522
- . Differentiation and function of Th17 T cells. Curr. Opin. Immunol. 2007;19:281–286
- . An interferon-gamma-producing Th1 subset is the major source of IL-17 in experimental autoimmune encephalitis. J. Neuroimmunol. 2007;183:96–103
- . A novel transcription factor, T-bet, directs Th1 lineage commitment. Cell. 2000;100:655–669
- . TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells. Immunity. 2006;24:179–189
- . Global mapping of H3K4me3 and H3K27me3 reveals specificity and plasticity in lineage fate determination of differentiating CD4+ T cells. Immunity. 2009;30:155–167
- . Development, cytokine profile and function of human interleukin 17-producing helper T cells. Nat. Immunol. 2007;8:950–957
PII: S0165-5728(09)00271-9
doi: 10.1016/j.jneuroim.2009.07.007
© 2009 Elsevier B.V. All rights reserved.
« Previous
Next »
Journal of Neuroimmunology
Volume 215, Issue 1
, Pages 10-24
, 30 October 2009
