Plasma levels of inflammatory and thrombotic/fibrinolytic markers in acute ischemic strokes: Relationship with TOAST subtype, outcome and infarct site
Abstract
Background
The aim of our study was to evaluate in patients with acute ischemic stroke the relationship between immuno-inflammatory variables, clinical outcome and infarct site.
Materials and methods
We evaluated plasma levels of IL-1β, TNF-α, IL-6 and IL-10, E-selectin, P-selectin, sICAM-1 ,sVCAM-1 vWF, TPA and PAI-1.
Results
Patients with cardioembolic subtype showed significantly higher median plasma levels of TNF-α, IL-6, IL-1β whereas the lacunar subtype showed significantly lower median plasma levels of TNF-α, IL-6 and IL-1β.
Conclusions
A significant association was noted between the severity of neurological deficit at admission, the diagnostic subtype and some inflammatory variables.
Keywords: Cerebral infarct, Cerebrovascular accident, Cerebrovascular disease, Inflammation, Risk factors, Stroke, Cytokines
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PII: S0165-5728(09)00259-8
doi:10.1016/j.jneuroim.2009.06.019
© 2009 Elsevier B.V. All rights reserved.
