Plasma levels of inflammatory and thrombotic/fibrinolytic markers in acute ischemic strokes: Relationship with TOAST subtype, outcome and infarct site
Received 28 January 2009; received in revised form 19 June 2009; accepted 19 June 2009. published online 20 August 2009.
Abstract
Background
The aim of our study was to evaluate in patients with acute ischemic stroke the relationship between immuno-inflammatory variables, clinical outcome and infarct site.
Materials and methods
We evaluated plasma levels of IL-1β, TNF-α, IL-6 and IL-10, E-selectin, P-selectin, sICAM-1 ,sVCAM-1 vWF, TPA and PAI-1.
Results
Patients with cardioembolic subtype showed significantly higher median plasma levels of TNF-α, IL-6, IL-1β whereas the lacunar subtype showed significantly lower median plasma levels of TNF-α, IL-6 and IL-1β.
Conclusions
A significant association was noted between the severity of neurological deficit at admission, the diagnostic subtype and some inflammatory variables.
ABSTRACT