Journal of Neuroimmunology
Volume 192, Issue 1 , Pages 13-20 , December 2007

Anti-thyroperoxidase antibodies from patients with Hashimoto's encephalopathy bind to cerebellar astrocytes

  • Stéphanie Blanchin

      Affiliations

    • Laboratoire d’Immunologie et d’Immunopathologie, UPRES-EA 2128, CHU Clémenceau, 14033 Caen cedex, France
    • Corresponding Author InformationCorresponding author. Tel.: +33 231 272 551; fax: +33 231 272 550.
  • ,
  • Christine Coffin

      Affiliations

    • Service d’Endocrinologie et Maladies Métaboliques, CHU Côte de Nacre, 14033 Caen cedex, France
  • ,
  • Fausto Viader

      Affiliations

    • Service de Neurologie, CHU Côte de Nacre, 14033 Caen cedex, France
  • ,
  • Jean Ruf

      Affiliations

    • INSERM U555, Faculté de médecine Timone, Université de la Méditerranée, 13385, Marseille cedex 5, France
  • ,
  • Pierre Carayon

      Affiliations

    • INSERM U555, Faculté de médecine Timone, Université de la Méditerranée, 13385, Marseille cedex 5, France
  • ,
  • Francette Potier

      Affiliations

    • Laboratoire d’Immunologie et d’Immunopathologie, UPRES-EA 2128, CHU Clémenceau, 14033 Caen cedex, France
  • ,
  • Estelle Portier

      Affiliations

    • Laboratoire d’Immunologie et d’Immunopathologie, UPRES-EA 2128, CHU Clémenceau, 14033 Caen cedex, France
  • ,
  • Elisabeth Comby

      Affiliations

    • Laboratoire d’Immunologie et d’Immunopathologie, UPRES-EA 2128, CHU Clémenceau, 14033 Caen cedex, France
  • ,
  • Stéphane Allouche

      Affiliations

    • Laboratoire de Biochimie, CHU Côte de Nacre, 14033 Caen cedex, France
  • ,
  • Yann Ollivier

      Affiliations

    • Service de Médecine Interne, CHU Côte de Nacre, 14033 Caen cedex, France
  • ,
  • Yves Reznik

      Affiliations

    • Service d’Endocrinologie et Maladies Métaboliques, CHU Côte de Nacre, 14033 Caen cedex, France
  • ,
  • Jean Jacques Ballet

      Affiliations

    • Laboratoire d’Immunologie et d’Immunopathologie, UPRES-EA 2128, CHU Clémenceau, 14033 Caen cedex, France

Received 28 June 2007 ,Revised 31 July 2007 ,Accepted 6 August 2007.

References 

  1. Blasko I, Stampfer-Kountchev M, Robatscher P, Veerhuis R, Eikelenboom P, Grubeck-Loebenstein B. How chronic inflammation can affect the brain and support the development of Alzheimer's disease in old age: the role of microglia and astrocytes. Aging Cell. 2004;3:169–176
  2. Brain , Jellinek EH, Ball K. Hashimoto's disease and encephalopathy. Lancet. 1966;2:512–514
  3. Castillo P, Woodruff B, Caselli R, Vernino S, Lucchinetti C, Swanson J, et al. Steroid-responsive encephalopathy associated with autoimmune thyroiditis. Arch. Neurol. 2006;63:197–202
  4. Chaudhuri A, Behan PO. The clinical spectrum, diagnosis, pathogenesis and treatment of Hashimoto's encephalopathy (recurrent acute disseminated encephalomyelitis). Curr. Med. Chem. 2003;10:1945–1953
  5. Chazenbalk GD, Costante G, Portolano S, McLachlan SM, Rapoport B. The immunodominant region on human thyroid peroxidase recognized by autoantibodies does not contain the monoclonal antibody 47/c21 linear epitope. J. Clin. Endocrinol. Metab. 1993;77:1715–1718
  6. Chong JY, Rowland LP, Utiger RD. Hashimoto encephalopathy: syndrome or myth?. Arch. Neurol. 2003;60:164–171
  7. Chuquet J, Hollender L, Nimchinsky EA. High-resolution in vivo imaging of the neurovascular unit during spreading depression. J. Neurosci. 2007;27:4036–4044
  8. Comby E, Tanaff P, Mariotte D, Costentin-Pignol V, Marcelli C, Ballet JJ. Evolution of antinuclear antibodies and clinical patterns in patients with active rheumatoid arthritis with longterm infliximab therapy. J. Rheumatol. 2006;33:24–30
  9. Dalakas MC, Fujii M, Li M, McElroy B. The clinical spectrum of anti-GAD antibody-positive patients with stiff-person syndrome. Neurology. 2000;55:1531–1535
  10. Fatourechi V. Hashimoto's encephalopathy: myth or reality? An endocrinologist's perspective. Best Pract. Res. Clin. Endocrinol. Metab. 2005;19:53–66
  11. Ferracci F, Moretto G, Candeago RM, Cimini N, Conte F, Gentile M, et al. Antithyroid antibodies in the CSF: their role in the pathogenesis of Hashimoto's encephalopathy. Neurology. 2003;60:712–714
  12. Ferracci F, Bertiato G, Moretto G. Hashimoto's encephalopathy: epidemiologic data and pathogenetic considerations. J. Neurol. Sci. 2004;217:165–168
  13. Fujii A, Yoneda M, Ito T, Yamamura O, Satomi S, Higa H, et al. Autoantibodies against the amino terminal of alpha-enolase are a useful diagnostic marker of Hashimoto's encephalopathy. J. Neuroimmunol. 2005;162:130–136
  14. Guo J, Jaume JC, Rapoport B, McLachlan SM. Recombinant thyroid peroxidase-specific Fab converted to immunoglobulin G (IgG) molecules: evidence for thyroid cell damage by IgG1, but not IgG4, autoantibodies. J. Clin. Endocrinol. Metab. 1997;82:925–931
  15. Kothbauer-Margreiter I, Sturzenegger M, Komor J, Baumgartner R, Hess CW. Encephalopathy associated with Hashimoto thyroiditis: diagnosis and treatment. J. Neurol. 1996;243:585–593
  16. Mulhern LM, Masi AT, Shulman LE. Hashimoto's disease. A search for associated disorders in 170 clinically detected cases. Lancet. 1966;2:508–511
  17. Nolte KW, Unbehaun A, Sieker H, Kloss TM, Paulus W. Hashimoto encephalopathy: a brainstem vasculitis?. Neurology. 2000;54:769–770
  18. Ochi H, Horiuchi I, Araki N, Toda T, Araki T, Sato K, et al. Proteomic analysis of human brain identifies alpha-enolase as a novel autoantigen in Hashimoto's encephalopathy. FEBS Lett. 2002;528:197–202
  19. Oide T, Tokuda T, Yazaki M, Watarai M, Mitsuhashi S, Kaneko K, et al. Anti-neuronal autoantibody in Hashimoto's encephalopathy: neuropathological, immunohistochemical, and biochemical analysis of two patients. J. Neurol. Sci. 2004;217:7–12
  20. Pop VJ, de Vries E, van Baar AL, Waelkens JJ, de Rooy HA, Horsten M, et al. Maternal thyroid peroxidase antibodies during pregnancy: a marker of impaired child development?. J. Clin. Endocrinol. Metab. 1995;80:3561–3566
  21. Pop VJ, Maartens LH, Leusink G, van Son MJ, Knottnerus AA, Ward AM, et al. Are autoimmune thyroid dysfunction and depression related?. J. Clin. Endocrinol. Metab. 1998;83:3194–3197
  22. Rodien P, Madec AM, Ruf J, Rajas F, Bornet H, Carayon P, et al. Antibody-dependent cell-mediated cytotoxicity in autoimmune thyroid disease: relationship to antithyroperoxidase antibodies. J. Clin. Endocrinol. Metab. 1996;81:2595–2600
  23. Rosenfeld MR, Wong E, Dalmau J, Manley G, Posner JB, Sher E, et al. Cloning and characterization of a Lambert–Eaton myasthenic syndrome antigen. Ann. Neurol. 1993;33:113–120
  24. Ruf J, Carayon P. Structural and functional aspects of thyroid peroxidase. Arch. Biochem. Biophys. 2006;445:269–277
  25. Ruf J, Carayon P, Sarles-Philip N, Kourilsky F, Lissitzky S. Specificity of monoclonal antibodies against human thyroglobulin; comparison with autoimmune antibodies. EMBO J. 1983;2:1821–1826
  26. Ruf J, Toubert ME, Czarnocka B, Durand-Gorde JM, Ferrand M, Carayon P. Relationship between immunological structure and biochemical properties of human thyroid peroxidase. Endocrinology. 1989;125:1211–1218
  27. Ruf J, Ferrand M, Durand-Gorde JM, Carayon P. Immunopurification and characterization of thyroid autoantibodies with dual specificity for thyroglobulin and thyroperoxidase. Autoimmunity. 1992;11:179–188
  28. Sawka AM, Fatourechi V, Boeve BF, Mokri B. Rarity of encephalopathy associated with autoimmune thyroiditis: a case series from Mayo Clinic from 1950 to 1996. Thyroid. 2002;12:393–398
  29. Schipper HM. Astrocytes, brain aging, and neurodegeneration. Neurobiol. Aging. 1996;17:467–480
  30. Selim M, Drachman DA. Ataxia associated with Hashimoto's disease: progressive non-familial adult onset cerebellar degeneration with autoimmune thyroiditis. J. Neurol. Neurosurg. Psychiatry. 2001;71:81–87
  31. Sutton I, Winer JB. The immunopathogenesis of paraneoplastic neurological syndromes. Clin. Sci. 2002;102:475–486
  32. Wadeleux P, Winand-Devigne J, Ruf J, Carayon P, Winand R. Cytotoxic assay of circulating thyroid peroxidase antibodies. Autoimmunity. 1989;4:247–254
  33. Yoneda M, Fujii A, Ito A, Yokoyama H, Nakagawa H, Kuriyama M. High prevalence of serum autoantibodies against the amino terminal of alpha-enolase in Hashimoto's encephalopathy. J. Neuroimmunol. 2007;185:195–200

PII: S0165-5728(07)00270-6

doi: 10.1016/j.jneuroim.2007.08.012

Journal of Neuroimmunology
Volume 192, Issue 1 , Pages 13-20 , December 2007