Journal of Neuroimmunology
Volume 192, Issue 1 , Pages 13-20, December 2007

Anti-thyroperoxidase antibodies from patients with Hashimoto's encephalopathy bind to cerebellar astrocytes

  • Stéphanie Blanchin

      Affiliations

    • Laboratoire d’Immunologie et d’Immunopathologie, UPRES-EA 2128, CHU Clémenceau, 14033 Caen cedex, France
    • Corresponding Author InformationCorresponding author. Tel.: +33 231 272 551; fax: +33 231 272 550.
    • ,
  • Christine Coffin

      Affiliations

    • Service d’Endocrinologie et Maladies Métaboliques, CHU Côte de Nacre, 14033 Caen cedex, France
    • ,
  • Fausto Viader

      Affiliations

    • Service de Neurologie, CHU Côte de Nacre, 14033 Caen cedex, France
    • ,
  • Jean Ruf

      Affiliations

    • INSERM U555, Faculté de médecine Timone, Université de la Méditerranée, 13385, Marseille cedex 5, France
    • ,
  • Pierre Carayon

      Affiliations

    • INSERM U555, Faculté de médecine Timone, Université de la Méditerranée, 13385, Marseille cedex 5, France
    • ,
  • Francette Potier

      Affiliations

    • Laboratoire d’Immunologie et d’Immunopathologie, UPRES-EA 2128, CHU Clémenceau, 14033 Caen cedex, France
    • ,
  • Estelle Portier

      Affiliations

    • Laboratoire d’Immunologie et d’Immunopathologie, UPRES-EA 2128, CHU Clémenceau, 14033 Caen cedex, France
    • ,
  • Elisabeth Comby

      Affiliations

    • Laboratoire d’Immunologie et d’Immunopathologie, UPRES-EA 2128, CHU Clémenceau, 14033 Caen cedex, France
    • ,
  • Stéphane Allouche

      Affiliations

    • Laboratoire de Biochimie, CHU Côte de Nacre, 14033 Caen cedex, France
    • ,
  • Yann Ollivier

      Affiliations

    • Service de Médecine Interne, CHU Côte de Nacre, 14033 Caen cedex, France
    • ,
  • Yves Reznik

      Affiliations

    • Service d’Endocrinologie et Maladies Métaboliques, CHU Côte de Nacre, 14033 Caen cedex, France
    • ,
  • Jean Jacques Ballet

      Affiliations

    • Laboratoire d’Immunologie et d’Immunopathologie, UPRES-EA 2128, CHU Clémenceau, 14033 Caen cedex, France

Received 28 June 2007; received in revised form 31 July 2007; accepted 6 August 2007. published online 29 October 2007.

Abstract 

A cohort of 10 Hashimoto's encephalopathy (HE) patients, 33 patients with unrelated neurological symptoms, 12 Hashimoto's thyroiditis patients and 4 healthy adult donors was studied to explore the neurological targets of anti-thyroperoxidase (TPO) autoantibodies (aAb) in HE. High levels of anti-TPO aAb were only detected in HE group's cerebrospinal fluids. In immunofluorescence assays on monkey brain cerebellum sections, both HE patients' sera and anti-TPO monoclonal antibodies (mAb) were able to bind cerebellar cells expressing glial fibrillary acid protein. Normal human astrocytes from primary cultures also reacted with anti-TPO mAb. Specific astrocyte binding of anti-TPO aAb suggests a role of these aAb in the HE pathogenesis.

Keywords: Anti-thyroperoxidase antibodies, Astrocytes, Cerebrospinal fluid, Hashimoto's encephalopathy, Hashimoto's thyroiditis

To access this article, please choose from the options below

Login to an existing account or Register a new account.

  • Purchase this article for 31.50 USD (You must login/register to purchase this article)

    Online access for 24 hours. The PDF version can be downloaded as your permanent record.

  • Subscribe to this title

    Get unlimited online access to this article and all other articles in this title 24/7 for one year.

  • Claim access now

    For current subscribers with Society Membership or Account Number.

  • Visit SciVerse ScienceDirect to see if you have access via your institution.
 

PII: S0165-5728(07)00270-6

doi:10.1016/j.jneuroim.2007.08.012

Journal of Neuroimmunology
Volume 192, Issue 1 , Pages 13-20, December 2007

Article Tools

* Image Usage & Resolution