Phenotypic characterization of autoreactive T cells in multiple sclerosis

Ratts, Robert B.; Karandikar, Nitin J.; Hussain, Rehana Z.; Choy, Judy; Northrop, Sara C.; Lovett-Racke, Amy E.; Racke, Michael K.

doi:10.1016/j.jneuroim.2006.06.010

« Previous Next »Journal of Neuroimmunology
Volume 178, Issue 1 , Pages 100-110, September 2006

Phenotypic characterization of autoreactive T cells in multiple sclerosis

Robert B. Ratts
- Department of Neurology, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390-9036, USA
Nitin J. Karandikar
- Department of Neurology, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390-9036, USA
- Department of Pathology, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390-9072, USA
Rehana Z. Hussain
- Department of Neurology, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390-9036, USA
Judy Choy
- Department of Neurology, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390-9036, USA
Sara C. Northrop
- Department of Neurology, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390-9036, USA
Amy E. Lovett-Racke
- Department of Neurology, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390-9036, USA
Michael K. Racke
- Department of Neurology, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390-9036, USA
- Corresponding author. Current address: The Ohio State University Medical Center, 1654 Upham Drive, 445 Means Hall, Columbus, OH 43210-1228, United States. Tel.: +1 614 293 4036; fax: +1 614 293 9029.

Received 8 April 2006; received in revised form 9 June 2006; accepted 13 June 2006. published online 10 August 2006.

Abstract

MS has been hypothesized to result from autoreactive T cell responses against myelin antigens. In this report, we examined myelin-specific CD8 and CD4 T cells for two markers differentially expressed on naïve, memory and chronically stimulated T cells, CD28 and CD57. We observed differential expression on CD8 T cells in response to myelin antigens, but not in response to the recall antigen mumps. We demonstrate these cells display reduced proliferation and this may explain why therapies that limit the proliferation of T cells have had little effect on the course of MS, particularly later in the course of the disease.

Keywords: T cells, Autoimmunity, CD81