Journal of Neuroimmunology
Volume 171, Issue 1 , Pages 1-7, February 2006

Mast cells modulate maintained neuronal activity in the thalamus in vivo

  • Péter Kovács

      Affiliations

    • University of Pécs, Department of Experimental Zoology and Neurobiology, 6 Ifjúság str., H-7624, Pécs, Hungary
    • Corresponding Author InformationCorresponding author. Tel.: +36 72503600x4613 or 4816; mobile: +36 702895618; fax: +36 72501517.
    • ,
  • István Hernádi

      Affiliations

    • University of Pécs, Department of Experimental Zoology and Neurobiology, 6 Ifjúság str., H-7624, Pécs, Hungary
    • University of Cambridge, Department of Anatomy, Downing Street, Cambridge, CB2 3DY, United Kingdom
    • ,
  • Márta Wilhelm

      Affiliations

    • University of Pécs, Institute of Physical Education and Sport Sciences, 6 Ifjúság str., H-7624, Pécs, Hungary

Received 22 April 2005; accepted 15 July 2005. published online 21 November 2005.

Abstract 

Single cell unit activity of 187 neurons of 24 rats were analysed to study the possible involvement of intracranial mast cells on modifying thalamic neuronal activity. Mast cells were activated with microiontophoretical application of compound 48/80. This substance did not modify the firing rate of cortical or hippocampal neurons (no mast cells are found here), however it caused excitation (70% in females, 11% in males), or inhibition (7% in females, 33% in males) on thalamic neurons, possibly due to mast cell activation. In consecutive anatomical evaluation many partially or fully degranulated mast cells were found in the recorded thalamic areas.

Keywords: Compound 48/80, Iontophoresis, Mast cells

To access this article, please choose from the options below

Login to an existing account or Register a new account.

  • Purchase this article for 31.50 USD (You must login/register to purchase this article)

    Online access for 24 hours. The PDF version can be downloaded as your permanent record.

  • Subscribe to this title

    Get unlimited online access to this article and all other articles in this title 24/7 for one year.

  • Claim access now

    For current subscribers with Society Membership or Account Number.

  • Visit SciVerse ScienceDirect to see if you have access via your institution.
 

PII: S0165-5728(05)00314-0

doi:10.1016/j.jneuroim.2005.07.026

Journal of Neuroimmunology
Volume 171, Issue 1 , Pages 1-7, February 2006

Article Tools

* Image Usage & Resolution