-
Data integration and systems biology approaches for biomarker discovery: Challenges and opportunities for multiple sclerosis
27 January 2012
Pablo Villoslada, Sergio Baranzini
Abstract: New “omic” technologies and their application to systems biology approaches offer new opportunities for biomarker discovery in complex disorders, including multiple sclerosis (MS). Recent st...
-
Key role of CXCL13/CXCR5 axis for cerebrospinal fluid B cell recruitment in pediatric OMS
24 January 2012
Michael R. Pranzatelli, Elizabeth D. Tate, Nathan R. McGee, Anna L. Travelstead, Richard M. Ransohoff, Jayne M. Ness, Jerry A. Colliver
Abstract: To study aberrant B cell trafficking into the CSF in opsoclonus–myoclonus syndrome (OMS), chemoattractants CXCL13 and CXCL12, and B cell frequency and CXCR5 expression, were evaluated. CSF C...
-
Elevation of serum TNF-α levels in mild and moderate Alzheimer patients with daytime sleepiness
24 January 2012
Rui Chen, You Yin, Zhongxin Zhao, Liuqing Huang, Shuqi Huang, Jianhua Zhuang, Huijuan Wu, Hua Peng, Peng Li
Abstract: Objectives: Sleep disturbance has been noted to accompany Alzheimer disease and is more pronounced as dementia severity increases. The aim of this study was to examine whether sleep disturba...
-
Rapamycin reduces clinical signs and neuropathic pain in a chronic model of experimental autoimmune encephalomyelitis
20 January 2012
L. Lisi, P. Navarra, R. Cirocchi, A. Sharp, E. Stigliano, D.L. Feinstein, C. Dello Russo
Abstract: Current treatments used in Multiple Sclerosis (MS) are partly effective in the early stages of the disease but display very limited benefits in patients affected by progressive MS. One possi...
-
Meningothelial cells participate in immunological processes in the cerebrospinal fluid
20 January 2012
Bin Fan, Giovanna Bordigari, Josef Flammer, Hanspeter E. Killer, Peter Meyer, Albert Neutzner
Abstract: Meningothelial cells (MECs) form the innermost layer of the meningeal sheath and as such are in direct contact with the cerebrospinal fluid (CSF) likely influencing CSF composition. The CSF ...
View More Articles in Press...