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Altered frequency of T regulatory cells is associated with disability status in relapsing–remitting multiple sclerosis patients
18 May 2012
Lasse Bjerg, Anne Brosbøl-Ravnborg, Caroline Tørring, Anders Dige, Bettina Bundgaard, Thor Petersen, Per Höllsberg
Abstract: A perturbed immunoregulation may be part of the pathogenesis of relapsing–remitting multiple sclerosis (RRMS). In this study, we demonstrate a dichotomy within the frequency of Treg among ne...
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Effects of interferon-beta therapy on elements in the antiviral immune response towards the human herpesviruses EBV, HSV, and VZV, and to the human endogenous retroviruses HERV-H and HERV-W in multiple sclerosis
18 May 2012
Thor Petersen, Anné Møller-Larsen, Svend Ellermann-Eriksen, Steffen Thiel, Tove Christensen
Abstract: Effects of treatment of multiple sclerosis patients with IFN-β on elements of the antiviral immune response to herpesviruses were analysed in a longitudinal study. We found significantly inc...
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Interleukin-10 expression during the acute phase is a putative prerequisite for delayed viral elimination in a murine model for multiple sclerosis
16 May 2012
Vanessa Herder, Ingo Gerhauser, Stephanie Kristin Klein, Pedro Almeida, Maren Kummerfeld, Reiner Ulrich, Frauke Seehusen, Karl Rohn, Dirk Schaudien, Wolfgang Baumgärtner, Jochen Huehn, Andreas Beineke
Abstract: Reduced protective immunity leads to viral persistence and demyelination in Theiler's murine encephalomyelitis. The aim of the present study was to compare the phenotype of brain-infiltratin...
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Alteration of immunologic responses on peripheral blood in the acute phase of ischemic stroke: Blood genomic profiling study
16 May 2012
Seung-Hun Oh, Ok-Joon Kim, Dong-Ah Shin, Jihwan Song, Hanna Yoo, Yu-Kyung Kim, Jin-Kyeoung Kim
Abstract: Objective: Peripheral blood cells and inflammatory mediators have a detrimental effect on brain during cerebral ischemia. We investigated the immunologic changes on peripheral blood in the a...
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Lipids and lipid-reactive antibodies as biomarkers for multiple sclerosis
14 May 2012
Francisco J. Quintana, Ada Yeste, Howard L. Weiner, Ruxandra Covacu
Abstract: Multiple sclerosis (MS) is an autoimmune disease that targets the central nervous system (CNS). MS initially follows a relapsing–remitting course (RRMS) in which acute attacks are followed b...
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